The coordination of anionic donors is involved at various stages of catalytic cycles in transition-metal catalysis, but control over the spatial positioning of anions around a metal center is a challenge in coordination chemistry. Here we show that regioisomeric phosphine-carboxylate ligands provide spatial anion control on palladium(II) centers by...

N-heterocyclic imines such as pyridylidene amines impart high catalytic activity when coordinated to a transition metal, largely imposed by their electronic flexibility. Here, this donor flexibility has been applied for the first time to CAAC-based systems through the synthesis of CAAC-triazenes. These new ligands offer a larger π-conjugating that extends...

An acyclic phosphonate-linked nucleic acid backbone (ZNA) demonstrated the capability to support duplex formation and propagate genetic information in vivo, unveiling its potential for evolution into a synthetic genetic system (XNA). To determine the structural impact of such modification, modified Dickerson Drew DNA dodecamers (DDDs) were prepared...

Main group Bi-based materials have gained popularity as N2 reduction reaction (NRR) photo/electrocatalysts due to their ability to inhibit competitive H2 evolution reactions (HER) and the unique N2 adsorption activities. The introduction of defects in Bi-based catalysts represents a highly effective strategy for enhancing light absorption, promoting...

C-type lectins, a large superfamily of proteins, are crucial in immunity and homeostasis. Their C-type lectin-like domain enables them to bind a wide range of ligands, including those not dependent on Ca2+ interactions. This adaptability is further enhanced by their variable domain architecture and conformational plasticity. Secondary binding sites,...

A series of bright chemogenetic reporters based on the HaloTag technology with green to red emission range were obtained by combining the molecular engineering of chemically-accessible fluorescent molecular rotors with mutations of the HaloTag protein. The reporters are suitable for wash-free live cell imaging with good contrast and the design strategy...