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Organic solvent enhances oxidative folding of disulfide-rich proteins

Nature Chemistry, Published online: 18 April 2024; doi:10.1038/s41557-024-01518-9Natural protein folding takes place in aqueous cell environments. Now, it has been found that proteins in a water-free environment undergo faster and more efficient folding.

Thu Apr 18, 2024 13:12
A <i>para</i>- to <i>meta</i>-isomerization of phenols

Nature Chemistry, Published online: 17 April 2024; doi:10.1038/s41557-024-01512-1Phenols and their derivatives are ubiquitous in nature and important within the chemical industry. Their properties are linked to their substitution patterns, but meta-isomers are underrepresented due to the difficulty of their synthesis. Now we address this challenge by...

Wed Apr 17, 2024 14:07
Stereoretentive enantioconvergent reactions

Nature Chemistry, Published online: 17 April 2024; doi:10.1038/s41557-024-01504-1Enantioconvergent reactions convert both enantiomers of a racemic starting material into a single enantioenriched product. All currently known enantioconvergent processes necessitate the loss or partial loss of the racemic substrate’s stereochemical information. Now, an...

Wed Apr 17, 2024 14:07
Stereodivergent photobiocatalytic radical cyclization through the repurposing and directed evolution of fatty acid photodecarboxylases

Nature Chemistry, Published online: 17 April 2024; doi:10.1038/s41557-024-01494-0Despite their intriguing photochemical activities, natural photoenzymes have not yet been repurposed for new-to-nature activities. Now, by leveraging the strongly oxidizing excited-state flavoquinone cofactor, fatty acid photodecarboxylases were engineered to catalyse unnatural...

Wed Apr 17, 2024 14:07
Mechanically triggered on-demand degradation of polymers synthesized by radical polymerizations

Nature Chemistry, Published online: 12 April 2024; doi:10.1038/s41557-024-01508-xRadical polymerizations yield polymers that cannot easily be degraded. The co-polymerization of cyclobutene-based monomers with conventional vinyl monomers has now been shown to result in co-polymers with cyclobutane mechanophores in their backbone, which facilitate on-demand...

Fri Apr 12, 2024 14:13
Bioorthogonal masked acylating agents for proximity-dependent RNA labelling

Nature Chemistry, Published online: 09 April 2024; doi:10.1038/s41557-024-01493-1RNA localization is key to regulating cellular function but is challenging to measure in an unbiased manner. Now a combination of enol-masked acylating probes with a bioorthogonal esterase to locally unmask them provides a non-radical RNA proximity labelling platform—termed...

Tue Apr 9, 2024 12:52

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