Receiving a diagnosis of chronic kidney disease (CKD) can be devasting to patients and their families. Patients with CKD and their care partners often face a lifetime of daily battles resulting from numerous symptoms and the disease’s complex pathophysiology. Many face progressive decline in kidney function and the possible need for kidney replacement...

Advocates for improved equity in kidney transplant in the US have recently focused efforts on initiatives to increase referral for transplant evaluation. However, because donor kidneys remain scarce, increased referrals are likely to result in an increasing number of patients proceeding through the evaluation process without ultimately receiving a kidney....

“Variability is the law of life, and as no two faces are the same, so no two bodies are alike, and no two individuals react alike and behave alike under the abnormal conditions which we know as disease…” Osler, Aequanimitas1

My Story (Antonia’s Perspective)

Less is more. Illustrations of the validity of this mantra in life and clinical medicine are not hard to find. Examples abound in the realm of critical care, such as with mechanical ventilation1 and transfusion targets.2 Perhaps the best example in critical care nephrology is in dose of continuous kidney replacement therapy (CKRT) for acute kidney injury...

APOL1 (OMIM 603743) -encoding apolipoprotein L1 (apoL1) is an evolutionarily new gene found only in humans and some primates with key roles in innate immunity against African trypanosomiasis (1) (2). Two African ancestry–related APOL1 gain-of-function haplotypes, G1 and G2, individually confer enhanced protection against human African trypanosomiasis...