CNPq10.13039/501100003593312410/2018-2435642/2018-9312306/2021-040906/2022-2409595/2023-3ARD10.13039/100011141Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul10.13039/50110000426321/2551-0000673-0Alzheimer’s AssociationAARGD-21-850670PronexInstituto Nacionalde Ciência e Tecnologia para Excitotoxicidade e Neuroproteção465671/2014-4Instituto...

AbstractGlial fibrillary acidic protein (GFAP), a proxy of astrocyte reactivity, has been proposed as biomarker of Alzheimer’s disease. However, there is limited information about the correlation between blood biomarkers and post-mortem neuropathology.In a single-centre prospective clinicopathological cohort of 139 dementia patients, for which the time-frame...

AbstractEpstein-Barr virus (EBV) infection has been advocated as a prerequisite for developing multiple sclerosis (MS) and possibly the propagation of the disease. However, the precise mechanisms for such influences are still unclear. A large-scale study investigating the host genetics of EBV serology and related clinical manifestations, such as infectious...

AbstractReading acquisition modifies areas of the brain associated with vision, with language, and their connections. Those changes enable reciprocal translation between orthography, and word sounds and meaning. Individual variability in the pre-existing cerebral substrate contributes to the range of eventual reading abilities, extending to atypical...

AbstractAdaptive coding of reward is the process by which neurons adapt their response to the context of available compensations. Higher rewards lead to a stronger brain response, but the increase of the response depends on the range of available rewards. A steeper increase is observed in a narrow range, and a more gradual slope in a wider range. In...

AbstractApilimod dimesylate is a first-in-class phosphoinositide kinase, FYVE-type zinc finger containing (PIKfyve) inhibitor with favourable clinical safety profile and has demonstrated activity in preclinical C9orf72 and TDP-43 amyotrophic lateral sclerosis models. In this amyotrophic lateral sclerosis clinical trial, the safety, tolerability, CNS...