J Tissue Eng Regen Med. 2021 Oct 1. doi: 10.1002/term.3255. Online ahead of print.ABSTRACTVentral hernia repair (VHR) with acellular dermal matrix (ADM) has high rates of recurrence that may be improved with allogeneic growth factor augmentation such as amniotic fluid allograft (AFA). We hypothesized that AFA would modulate the host response to improve...

J Pathol. 2021 Oct 1. doi: 10.1002/path.5811. Online ahead of print.ABSTRACTAs acute pancreatitis progresses to the severe form a life-threatening systemic inflammation is triggered. Although the mechanisms involved in this process are not yet well understood, it has been proposed that circulating exosomes may be involved in the progression of inflammation...

Allergy. 2021 Oct 2. doi: 10.1111/all.15122. Online ahead of print.ABSTRACTThe skin is the largest organ of the human body. It controls body temperature and hydroelectrochemical balance, protects the organism and maintains its integrated structures. Immunologically, the skin is endowed with a complex network of immune-functioning cells consisting of...

J Immunother Cancer. 2021 Oct;9(10):e002758. doi: 10.1136/jitc-2021-002758.ABSTRACTBACKGROUND: The major challenge of antitumor immunotherapy is dealing with the immunosuppressive tumor microenvironment, which involves immature myeloid cell accumulation that results in T cell dysfunction. Myeloid cell activation is induced by Toll-like receptor agonists....

J Immunother Cancer. 2021 Oct;9(10):e003464. doi: 10.1136/jitc-2021-003464.ABSTRACTBACKGROUND: T cell checkpoint immunotherapies have shown promising results in the clinic, but most patients remain non-responsive. CD47-signal regulatory protein alpha (SIRPα) myeloid checkpoint blockade has shown early clinical activity in hematologic malignancies. However,...

Cell Death Dis. 2021 Oct 1;12(10):898. doi: 10.1038/s41419-021-04180-y.ABSTRACTAcute lung injury (ALI) is a common lung pathology that is accompanied by alveolar macrophage (AM) activation and inflammatory response. This study investigated the role of the long non-coding RNA NONRATT004344 (hereafter named lncRNA NLRP3) in regulating the Nod-like receptor...