Journal of Biological Chemistry RSS feed -- recent Membrane Biology articles
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Transcription factors activated through RIP (regulated intramembrane proteolysis) and RAT (regulated alternative translocation) [Membrane Biology]

Transmembrane proteins are membrane-anchored proteins whose topologies are important for their functions. These properties enable regulation of certain transmembrane proteins by regulated intramembrane proteolysis (RIP) and regulated alternative translocation (RAT). RIP enables a protein fragment of a transmembrane precursor to function at a new location,...

Fri Jul 24, 2020 22:48
A cellular endolysosome-modulating pore-forming protein from a toad is negatively regulated by its paralog under oxidizing conditions [Membrane Biology]

Endolysosomes are key players in cell physiology, including molecular exchange, immunity, and environmental adaptation. They are the molecular targets of some pore-forming aerolysin-like proteins (ALPs) that are widely distributed in animals and plants and are functionally related to bacterial toxin aerolysins. βγ-CAT is a complex of an ALP (BmALP1)...

Fri Jul 24, 2020 22:48
Structural basis for the binding of SNAREs to the multisubunit tethering complex Dsl1 [Protein Structure and Folding]

Multisubunit-tethering complexes (MTCs) are large (250 to >750 kDa), conserved macromolecular machines that are essential for soluble N-ethylmaleimide–sensitive factor attachment protein receptor (SNARE)–mediated membrane fusion in all eukaryotes. MTCs are thought to organize membrane trafficking by mediating the initial long-range interaction between...

Fri Jul 24, 2020 22:48
Securing SNAREs for assembly [Membrane Biology]

SNARE proteins are essential for exocytosis, mediating the fusion of vesicles with their target membrane. Tethering factors play a key role in chaperoning SNARE assembly; however, the underlying molecular mechanisms are not well-understood. Here, Travis et al. report two crystal structures of a yeast tethering factor, the Dsl1 complex, bound with two...

Fri Jul 24, 2020 22:48
Crystal structure of a human plasma membrane phospholipid flippase [Bioenergetics]

ATP11C, a member of the P4-ATPase flippase, translocates phosphatidylserine from the outer to the inner plasma membrane leaflet, and maintains the asymmetric distribution of phosphatidylserine in the living cell. We present the crystal structures of a human plasma membrane flippase, ATP11C–CDC50A complex, in a stabilized E2P conformation. The structure...

Fri Jul 24, 2020 22:48
Transcription factors activated through RIP (regulated intramembrane proteolysis) and RAT (regulated alternative translocation) [Membrane Biology]

Transmembrane proteins are membrane-anchored proteins whose topologies are important for their functions. These properties enable regulation of certain transmembrane proteins by regulated intramembrane proteolysis (RIP) and regulated alternative translocation (RAT). RIP enables a protein fragment of a transmembrane precursor to function at a new location,...

Fri Jul 24, 2020 10:49

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