[ASAP] Discovery and Development of a Potent, Selective, and Orally Bioavailable CHK1 Inhibitor Candidate: 5-((4-((3-Amino-3-methylbutyl)amino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)picolinonitrile

Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.1c00994

8h

[ASAP] Discovery of IHMT-EZH2-115 as a Potent and Selective Enhancer of Zeste Homolog 2 (EZH2) Inhibitor for the Treatment of B-Cell Lymphomas

Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.1c01154

16h

[ASAP] Design of SARS-CoV-2 PLpro Inhibitors for COVID-19 Antiviral Therapy Leveraging Binding Cooperativity

Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.1c01307

16h

[ASAP] Targeted Delivery and Site-Specific Activation of β-Cyclodextrin-Conjugated Photosensitizers for Photodynamic Therapy through a Supramolecular Bio-orthogonal Approach

Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.1c01505

1d

[ASAP] Photosensitive and Photoswitchable TRPA1 Agonists Optically Control Pain through Channel Desensitization

Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.1c01579

1d

[ASAP] Tandem Repeat of a Short Human Chemerin-Derived Peptide and Its Nontoxic <sc>d</sc>-Lysine-Containing Enantiomer Display Broad-Spectrum Antimicrobial and Antitubercular Activities

Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.1c01352

1d

[ASAP] Imaging Autotaxin <italic toggle="yes">In Vivo</italic> with ¹⁸F-Labeled Positron Emission Tomography Ligands

Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.1c00913

1d

[ASAP] Imaging of Dysfunctional Elastogenesis in Atherosclerosis Using an Improved Gadolinium-Based Tetrameric MRI Probe Targeted to Tropoelastin

Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.1c01286

1d

[ASAP] Optimization and Evaluation of Novel Antifungal Agents for the Treatment of Fungal Infection

Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.1c01299

1d

[ASAP] Development of 2-(5,6,7-Trifluoro-1<italic toggle="yes">H</italic>-Indol-3-yl)-quinoline-5-carboxamide as a Potent, Selective, and Orally Available Inhibitor of Human Androgen Receptor Targeting Its Binding Function-3 for the Treatment of Castration-Resistant Prostate Cancer

Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.1c00681

1d