[ASAP] 4-Acyl Pyrroles as Dual BET-BRD7/9 Bromodomain Inhibitors Address BETi Insensitive Human Cancer Cell Lines

Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c00478

14h

[ASAP] Recent Advances in the Development of PD-L1 Modulators: Degraders, Downregulators, and Covalent Inhibitors <subtitle>Miniperspective</subtitle>

Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c01362

22h

[ASAP] Synthesis and Biological Characterization of Cyclic Disulfide-Containing Peptide Analogs of the Multifunctional Opioid/Neuropeptide FF Receptor Agonists That Produce Long-Lasting and Nontolerant Antinociception

Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c01367

1d

[ASAP] Iodinated Choline Transport-Targeted Tracers

Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c01710

1d

[ASAP] Modulation of the G-Protein-Coupled Receptor 84 (GPR84) by Agonists and Antagonists

Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c01378

1d

[ASAP] Advances toward COVID-19 Therapies Special Issue Call for Papers

Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c01963

2d

[ASAP] Discovery of Novel and Highly Potent Resorcinol Dibenzyl Ether-Based PD-1/PD-L1 Inhibitors with Improved Drug-like and Pharmacokinetic Properties for Cancer Treatment

Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c01684

2d

[ASAP] Discovery of Pamiparib (BGB-290), a Potent and Selective Poly (ADP-ribose) Polymerase (PARP) Inhibitor in Clinical Development

Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c01346

2d

[ASAP] Berberine Directly Targets the NEK7 Protein to Block the NEK7–NLRP3 Interaction and Exert Anti-inflammatory Activity

Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c01743

2d

[ASAP] Discovery of a Potent and Selective PI3Kδ Inhibitor (<italic toggle="yes">S</italic>)-2,4-Diamino-6-((1-(7-fluoro-1-(4-fluorophenyl)-4-oxo-3-phenyl-4<italic toggle="yes">H</italic>-quinolizin-2-yl)ethyl)amino)pyrimidine-5-carbonitrile with Improved Pharmacokinetic Profile and Superior Efficacy in Hematological Cancer Models

Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c01264

2d