[ASAP] 2-Arylbenzo[<italic toggle="yes">d</italic>]oxazole Phosphinate Esters as Second-Generation Modulators of Utrophin for the Treatment of Duchenne Muscular Dystrophy

Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c00807

2h

[ASAP] Synthesis and Structure–Activity Relationships of DCLK1 Kinase Inhibitors Based on a 5,11-Dihydro-6<italic toggle="yes">H</italic>-benzo[<italic toggle="yes">e</italic>]pyrimido[5,4-<italic toggle="yes">b</italic>][1,4]diazepin-6-one Scaffold

Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c00596

6h

[ASAP] Novel Autotaxin Inhibitor for the Treatment of Idiopathic Pulmonary Fibrosis: A Clinical Candidate Discovered Using DNA-Encoded Chemistry

Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c00688

18h

[ASAP] Artificial Intelligence in Drug Discovery: Into the Great Wide Open

Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c01077

1d

[ASAP] Structure-Based Drug Discovery of <italic toggle="yes">N</italic>-((<italic toggle="yes">R</italic>)-3-(7-Methyl-1<italic toggle="yes">H</italic>-indazol-5-yl)-1-oxo-1-(((<italic toggle="yes">S</italic>)-1-oxo-3-(piperidin-4-yl)-1-(4-(pyridin-4-yl)piperazin-1-yl)propan-2-yl)amino)propan-2-yl)-2'-oxo-1',2'-dihydrospiro[piperidine-4,4'-pyrido[2,3-<italic toggle="yes">d</italic>][1,3]oxazine]-1-carboxamide (HTL22562): A Calcitonin Gene-Related Peptide Receptor Antagonist for Acute Treatment of Migraine

Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c01003

2d

[ASAP] Discovery of 4-Phenylpiperidine-2-Carboxamide Analogues as Serotonin 5-HT_2C Receptor-Positive Allosteric Modulators with Enhanced Drug-like Properties

Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.9b01953

2d

[ASAP] Dual Targeting of Norepinephrine Transporter (NET) Function and Thyrointegrin avß3 Receptors in the Treatment of Neuroblastoma

Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c00537

2d

[ASAP] Nitrogen-Walk Approach to Explore Bioisosteric Replacements in a Series of Potent A_2B Adenosine Receptor Antagonists

Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c00564

2d

[ASAP] Topoisomerase Inhibitors Addressing Fluoroquinolone Resistance in Gram-Negative Bacteria

Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c00347

2d

[ASAP] Integrating the Impact of Lipophilicity on Potency and Pharmacokinetic Parameters Enables the Use of Diverse Chemical Space during Small Molecule Drug Optimization

Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.9b01813

2d