[ASAP] Identification of TNO155, an Allosteric SHP2 Inhibitor for the Treatment of Cancer

Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c01170

5h

[ASAP] Biased Agonism at Nociceptin/Orphanin FQ Receptors: A Structure Activity Study on N/OFQ(1–13)-NH₂

Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.9b02057

9h

[ASAP] Development of Bis-cyclic Imidazolidine-4-one Derivatives as Potent Antibacterial Agents

Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c00171

9h

[ASAP] Discovery of SK-575 as a Highly Potent and Efficacious Proteolysis-Targeting Chimera Degrader of PARP1 for Treating Cancers

Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c00821

14h

[ASAP] Optimized Opioid-Neurotensin Multitarget Peptides: From Design to Structure–Activity Relationship Studies

Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c01376

1d

[ASAP] Discovery of 9-Cyclopropylethynyl-2-((<italic toggle="yes">S</italic>)-1-[1,4]dioxan-2-ylmethoxy)-6,7-dihydropyrimido[6,1-<italic toggle="yes">a</italic>]isoquinolin-4-one (GLPG1205), a Unique GPR84 Negative Allosteric Modulator Undergoing Evaluation in a Phase II Clinical Trial

Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c00272

1d

[ASAP] Discovery and Development of SPR519 as a Potent, Selective, and Orally Bioavailable Inhibitor of PI3Kα and mTOR Kinases for the Treatment of Solid Tumors

Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c01061

1d

[ASAP] Discovery of Novel pERK1/2- or β-Arrestin-Preferring 5-HT_1A Receptor-Biased Agonists: Diversified Therapeutic-like versus Side Effect Profile

Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c00814

1d

[ASAP] Sulfoximines as Rising Stars in Modern Drug Discovery? Current Status and Perspective on an Emerging Functional Group in Medicinal Chemistry

Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c00960

1d

[ASAP] Therapeutic Exploitation of GPR18: Beyond the Cannabinoids? <subtitle>Miniperspective</subtitle>

Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c00926

1d