[ASAP] A Distributional Model of Bound Ligand Conformational Strain: From Small Molecules up to Large Peptidic Macrocycles

Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.2c01744

1h

[ASAP] Correction to “Importance of Binding Site Hydration and Flexibility Revealed When Optimizing a Macrocyclic Inhibitor of the Keap1–Nrf2 Protein–Protein Interaction”

Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.3c00037

1h

[ASAP] Novel Insights on CAI–CORM Hybrids: Evaluation of the CO Releasing Properties and Pain-Relieving Activity of Differently Substituted Coumarins for the Treatment of Rheumatoid Arthritis

Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.2c01706

1h

[ASAP] Screening through Lead Optimization of High Affinity, Allosteric Cyclin-Dependent Kinase 2 (CDK2) Inhibitors as Male Contraceptives That Reduce Sperm Counts in Mice

Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.2c01731

1h

[ASAP] Structure-Based Optimization of 2,4,5-Trisubstituted Pyrimidines as Potent HIV‑1 Non-Nucleoside Reverse Transcriptase Inhibitors: Exploiting the Tolerant Regions of the Non-Nucleoside Reverse Transcriptase Inhibitors’ Binding Pocket

Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.2c01875

6h

[ASAP] <italic toggle="yes">N</italic>‑Substituted <sc>l</sc>‑Iminosugars for the Treatment of Sanfilippo Type B Syndrome

Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.2c01617

21h

[ASAP] Design, Biological Evaluation, and Computer-Aided Analysis of Dihydrothiazepines as Selective Antichlamydial Agents

Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.2c01894

1d

[ASAP] Recent Advances on Small-Molecule Bromodomain-Containing Histone Acetyltransferase Inhibitors

Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.2c01638

1d

[ASAP] Chemical Optimization of CBL0137 for Human African Trypanosomiasis Lead Drug Discovery

Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.2c01767

1d

[ASAP] Discovery of AXL Degraders with Improved Potencies in Triple-Negative Breast Cancer (TNBC) Cells

Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.2c01682

1d