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Articles and research papers on cell division, cell structure, animal and plant cell biology and cell cycles.

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A complex epigenome-splicing crosstalk governs epithelial-to-mesenchymal transition in metastasis and brain development

Nature Cell Biology, Published online: 08 August 2022; doi:10.1038/s41556-022-00971-3Sahu et al. show that ZNF827 is essential for epithelial-to-mesenchymal transition in breast cancer metastasis and cortical development. Mechanistically, ZNF827 controls RNA splicing landscape by recruiting HDAC1 to slow RNA polymerase II progression.

The MARCHF6 E3 ubiquitin ligase acts as an NADPH sensor for the regulation of ferroptosis

Nature Cell Biology, Published online: 08 August 2022; doi:10.1038/s41556-022-00973-1Nguyen et al. show that the E3 ubiquitin ligase MARCHF6 acts as an NADPH sensor to suppress ferroptosis. Mechanistically, NADPH binds to MARCHF6 and activates its E3 ligase activity, enhancing the degradation of pro-ferroptosis proteins.

Vitamin E boosts immunotherapy

Nature Cell Biology, Published online: 08 August 2022; doi:10.1038/s41556-022-00979-9Vitamin E boosts immunotherapy

Roles for H3K9me3 in human embryos

Nature Cell Biology, Published online: 08 August 2022; doi:10.1038/s41556-022-00980-2Roles for H3K9me3 in human embryos

Untangling the web of intratumour heterogeneity

Nature Cell Biology, Published online: 08 August 2022; doi:10.1038/s41556-022-00969-xIn this Review, Polyak and colleagues discuss cellular and microenvironmental mechanisms that contribute to intratumour heterogeneity and how this affects immune escape and tumour progression.

Navigating ferroptosis via an NADPH sensor

Nature Cell Biology, Published online: 08 August 2022; doi:10.1038/s41556-022-00963-3NADPH levels serve as a biomarker of sensitivity to ferroptosis, but the regulators that detect cellular NADPH levels and modulate downstream ferroptosis responses are unknown. A study now identifies MARCHF6 in the ubiquitin system as an NADPH sensor that suppresses...

Roles for H3K9me3 in human embryos

Untangling the web of intratumour heterogeneity

Vitamin E boosts immunotherapy

The MARCHF6 E3 ubiquitin ligase acts as an NADPH sensor for the regulation of ferroptosis

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