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Articles and research papers on cell division, cell structure, animal and plant cell biology and cell cycles.

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Haematopoietic stem cell-dependent Notch transcription is mediated by p53 through the Histone chaperone Supt16h

Nature Cell Biology, Published online: 23 November 2020; doi:10.1038/s41556-020-00604-7Espanola et al. show in zebrafish that Supt16h, a component of the FACT complex, regulates HSC development through an increase of p53, which promotes expression of phc1, a transcriptional repressor of Notch.

Manipulating niche composition limits damage to haematopoietic stem cells during <i>Plasmodium</i> infection

Nature Cell Biology, Published online: 23 November 2020; doi:10.1038/s41556-020-00601-wHaltalli et al. show that Plasmodium berghei infection induces interferon release, and affects haematopoietic stem cell proliferation and function, as well as osteoblasts and vascular integrity, in the bone marrow niche.

Haematopoietic stem cell-dependent Notch transcription is mediated by p53 through the Histone chaperone Supt16h

Manipulating niche composition limits damage to haematopoietic stem cells during <i>Plasmodium</i> infection

Heat stress activates YAP/TAZ to induce the heat shock transcriptome

Nature Cell Biology, Published online: 16 November 2020; doi:10.1038/s41556-020-00602-9Luo et al. report that heat stress activates YAP to launch the heat shock transcriptome through inducing dephosphorylation and degradation of LATS independent of the upstream kinases MST and MAP4Ks.

Apoptosis in the fetal testis eliminates developmentally defective germ cell clones

Nature Cell Biology, Published online: 16 November 2020; doi:10.1038/s41556-020-00603-8Nguyen et al. show in mouse testes that germ cells are eliminated via apoptosis if they fail to differentiate properly due to errors in epigenetic reprogramming, a process that improves gamete quality.

Heat stress activates YAP/TAZ to induce the heat shock transcriptome

Apoptosis in the fetal testis eliminates developmentally defective germ cell clones

Phosphatidylinositol-3-OH kinase signalling is spatially organized at endosomal compartments by microtubule-associated protein 4

Nature Cell Biology, Published online: 02 November 2020; doi:10.1038/s41556-020-00596-4Intracellularly regulated PI3K activation. Thapa et al. find that phosphatidylinositol-3,4,5-trisphosphate generation and Akt activation occur at intracellular membranes, rather than the plasma membrane, and that this is mediated by MAP4, which controls PI3Kα localization...

A MAP for PI3K activation on endosomes

Nature Cell Biology, Published online: 02 November 2020; doi:10.1038/s41556-020-00597-3PI3K–Akt signalling downstream of cell-surface receptor activation has long been thought to occur at the plasma membrane. However, surprising evidence now reveals activation of PI3Kα-mediated PI(3,4,5)P3 synthesis on endosomal membranes that is dependent upon the...

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