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Articles and research papers on cell division, cell structure, animal and plant cell biology and cell cycles.

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PD-L1 controls cancer pyroptosis

Nature Cell Biology, Published online: 17 September 2020; doi:10.1038/s41556-020-00582-wProgrammed death ligand-1 (PD-L1) is well known for its role as an immune checkpoint regulator, but little is known about its function in other cellular processes. A study now shows that in tumour cells PD-L1 mediates pyroptosis, an inflammatory form of cell death,...

PD-L1 controls cancer pyroptosis

Author Correction: AP-1 imprints a reversible transcriptional programme of senescent cells

Nature Cell Biology, Published online: 16 September 2020; doi:10.1038/s41556-020-00589-3Author Correction: AP-1 imprints a reversible transcriptional programme of senescent cells

Author Correction: AP-1 imprints a reversible transcriptional programme of senescent cells

Nucleated transcriptional condensates amplify gene expression

Nature Cell Biology, Published online: 14 September 2020; doi:10.1038/s41556-020-00578-6Wei et al. show that clusters of unphosphorylated RNA polymerase II seed the nucleation of phase-separated condensates of TAF15, which further recruit RNA polymerase II to amplify transcriptional activation.

PD-L1-mediated gasdermin C expression switches apoptosis to pyroptosis in cancer cells and facilitates tumour necrosis

Nature Cell Biology, Published online: 14 September 2020; doi:10.1038/s41556-020-0575-zHou et al. show that following hypoxia PD-L1 translocates into the nucleus to enhance transcription of GSDMC, which is then cleaved and activated by caspase-8 to cause pyroptosis in cancer cells.

PD-L1-mediated gasdermin C expression switches apoptosis to pyroptosis in cancer cells and facilitates tumour necrosis

Nucleated transcriptional condensates amplify gene expression

lncRNA DIGIT and BRD3 protein form phase-separated condensates to regulate endoderm differentiation

lncRNA DIGIT and BRD3 protein form phase-separated condensates to regulate endoderm differentiation

Nature Cell Biology, Published online: 07 September 2020; doi:10.1038/s41556-020-0572-2Daneshvar et al. show that BRD3 and the lncRNA DIGIT form phase-separated condensates at genomic regions with H3K18ac to co-regulate the transcription of genes that drive endoderm differentiation.

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