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A selective small-molecule STAT5 PROTAC degrader capable of achieving tumor regression in vivo

Nature Chemical Biology, Published online: 02 February 2023; doi:10.1038/s41589-022-01248-4A potent and selective degrader was developed that depletes STAT5 in cells and mouse tissues, exerts cell growth inhibition in cells with activated STAT5 and induces tumor regression in mouse models.

3-Mercaptopyruvate sulfur transferase is a protein persulfidase

Nature Chemical Biology, Published online: 02 February 2023; doi:10.1038/s41589-022-01244-8Mercaptopyruvate sulfur transferase (MPST) is revealed as a protein persulfidase that acts directly on numerous and diverse target proteins, revealing potential origins of persulfidation as a common posttranslational modification.

Translation sees the light

Nature Chemical Biology, Published online: 31 January 2023; doi:10.1038/s41589-023-01263-zTranslation sees the light

A passage for linkers

Nature Chemical Biology, Published online: 31 January 2023; doi:10.1038/s41589-023-01261-1A passage for linkers

Probiotic hat trick

Nature Chemical Biology, Published online: 31 January 2023; doi:10.1038/s41589-023-01260-2Probiotic hat trick

Loops on the move

Nature Chemical Biology, Published online: 31 January 2023; doi:10.1038/s41589-023-01259-9Loops on the move

Detecting in flow

Nature Chemical Biology, Published online: 31 January 2023; doi:10.1038/s41589-023-01262-0Detecting in flow

Running through the blocks

Nature Chemical Biology, Published online: 31 January 2023; doi:10.1038/s41589-023-01264-yRunning through the blocks

Etoposide promotes DNA loop trapping and barrier formation by topoisomerase II

Nature Chemical Biology, Published online: 30 January 2023; doi:10.1038/s41589-022-01235-9Using single-molecule biophysics methods, Le et al. discovered that etoposide, a chemotherapeutic poison of topoisomerase II (topo II), promotes topo II to compact DNA, trap DNA loops and pause DNA supercoiling relaxation, thus converting topo II into a strong...

Topoisomerase II and etoposide — a tangled tale

Nature Chemical Biology, Published online: 30 January 2023; doi:10.1038/s41589-022-01236-8Etoposide, a chemotherapeutic poison of type IIA eukaryotic topoisomerases (topo IIs), promotes topo II to compact DNA by trapping DNA loops, creates DNA double-strand breaks, causes topo II to resist relocation, and pauses the ability of topoisomerases to relax...

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