Nature Chemical Biology, Published online: 30 September 2024; doi:10.1038/s41589-024-01740-zBiofouling causes a huge economic loss to our society. This Perspective examines the biofouling process from microfouling to macrofouling, discusses a spectrum of chemical signals that induce and inhibit biofouling and argues for potential management by targeting...

Nature Chemical Biology, Published online: 26 September 2024; doi:10.1038/s41589-024-01717-yThis Perspective discusses how macromolecular condensation can regulate the electrochemistry to affect biological function in living cells and provides a framework to study the electrochemical functions of biomolecular condensates.

Nature Chemical Biology, Published online: 25 September 2024; doi:10.1038/s41589-024-01734-xA nanopore-based framework distinguishes and quantifies tyrosine sulfation from phosphorylation in peptide mixtures and native protein fragments and determines the sequence of the sulfated fragment.

Nature Chemical Biology, Published online: 24 September 2024; doi:10.1038/s41589-024-01730-1An automation tool has been designed that enables partitioning of an algorithm into subcircuits split across cells for biological computing. The tool was applied to a hashing algorithm requiring 110 logic gates across 66 cells.

Nature Chemical Biology, Published online: 24 September 2024; doi:10.1038/s41589-024-01728-9The integration of a new orthogonal redox cofactor opens opportunities for controlling reaction equilibria. Because it does not interfere with cellular redox homeostasis, this approach enables the precise tuning of metabolic pathways and the optimization of microbial...

Nature Chemical Biology, Published online: 23 September 2024; doi:10.1038/s41589-024-01731-0The use of an adenine base editor enables identification of functional serine, threonine and tyrosine residues that impact cell fitness on a genome-wide scale with possible involvement in phosphorylation, structural maintenance and cancer biology.