Nature Chemical Biology, Published online: 26 April 2024; doi:10.1038/s41589-024-01615-3Engineering from evolution

Nature Chemical Biology, Published online: 26 April 2024; doi:10.1038/s41589-024-01616-2Bacteria lose a pep in their step

Nature Chemical Biology, Published online: 26 April 2024; doi:10.1038/s41589-024-01617-1Setting the pace for degrons

Nature Chemical Biology, Published online: 26 April 2024; doi:10.1038/s41589-024-01609-1A discovery pipeline integrating time-resolved HT-SAXS and fragment screening identifies chemical leads targeting exemplary allosteric states of mitochondrial oxidoreductase apoptosis-inducing factor (AIF).

Nature Chemical Biology, Published online: 25 April 2024; doi:10.1038/s41589-024-01596-3A small-molecule iron mobilizer, FeM-1269, minimally higher-order aggregates in aqueous media and effectively mobilizes iron across a range of concentrations. FeM-1269-promoted iron mobilization restores physiology in animals at well-tolerated doses.

Nature Chemical Biology, Published online: 25 April 2024; doi:10.1038/s41589-024-01613-5A tailored proteomics workflow to identify endogenous protein pyrophosphorylation in human cells was developed, revealing the dependence of the modification on inositol pyrophosphates and a putative function in rDNA transcription.