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Regulation of nitric oxide signaling by formation of a distal receptor–ligand complex

Nature Chemical Biology. doi:10.1038/nchembio.2488 Authors: Yirui Guo, Daniel L M Suess, Mark A Herzik, Anthony T Iavarone, R David Britt & Michael A Marletta

Inhibition of USP10 induces degradation of oncogenic FLT3

Nature Chemical Biology. doi:10.1038/nchembio.2486 Authors: Ellen L Weisberg, Nathan J Schauer, Jing Yang, Ilaria Lamberto, Laura Doherty, Shruti Bhatt, Atsushi Nonami, Chengcheng Meng, Anthony Letai, Renee Wright, Hong Tiv, Prafulla C Gokhale, Maria Stella Ritorto, Virginia De Cesare, Matthias Trost, Alexandra Christodoulou, Amanda...

Regulation of nitric oxide signaling by formation of a distal receptor–ligand complex

Inhibition of USP10 induces degradation of oncogenic FLT3

A homodimer interface without base pairs in an RNA mimic of red fluorescent protein

Nature Chemical Biology. doi:10.1038/nchembio.2475 Authors: Katherine Deigan Warner, Ljiljana Sjekloća, Wenjiao Song, Grigory S Filonov, Samie R Jaffrey & Adrian R Ferré-D'Amaré

RNA imaging: A tale of two G-quadruplexes

Nature Chemical Biology. doi:10.1038/nchembio.2492 Author: Aaron E Engelhart In contrast to proteins, no intrinsically fluorescent RNA is known to exist in nature. In this issue, a new, red-shifted aptamer–fluorophore complex for RNA imaging that has enhanced photostability is described. The crystal structure of this complex reveals...

Imaging RNA polymerase III transcription using a photostable RNA–fluorophore complex

Nature Chemical Biology. doi:10.1038/nchembio.2477 Authors: Wenjiao Song, Grigory S Filonov, Hyaeyeong Kim, Markus Hirsch, Xing Li, Jared D Moon & Samie R Jaffrey

RNA imaging: A tale of two G-quadruplexes

In contrast to proteins, no intrinsically fluorescent RNA is known to exist in nature. In this issue, a new, red-shifted aptamer–fluorophore complex for RNA imaging that has enhanced photostability is described. The crystal structure of this complex reveals a novel form of RNA small-molecule recognition.

Imaging RNA polymerase III transcription using a photostable RNA–fluorophore complex

A homodimer interface without base pairs in an RNA mimic of red fluorescent protein

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