Nature Chemical Biology, Published online: 01 December 2023; doi:10.1038/s41589-023-01508-xAuthor Correction: An engineered hypercompact CRISPR-Cas12f system with boosted gene-editing activity

Nature Chemical Biology, Published online: 29 November 2023; doi:10.1038/s41589-023-01488-ySmall molecules and drugs are not homogenously distributed across cells, and are instead enriched in distinct subcellular compartments and membraneless biomolecular condensates. A new study lays out the path to identifying chemical features or ‘rationales’ that...

Nature Chemical Biology, Published online: 27 November 2023; doi:10.1038/s41589-023-01489-xA workflow integrating tools from bioinformatics, structural biology and synthetic biology has been developed that enables the rapid design of pili-enabled living materials. This approach allows mining of pili-producing nonpathogenic chassis, understanding of...

Nature Chemical Biology, Published online: 23 November 2023; doi:10.1038/s41589-023-01485-1Efforts to rationally engineer nonribosomal peptide synthetase (NRPS) enzymes have focused on making individual modifications. Here the authors describe a targeted random engineering approach that uses thousands of NRPS domains amplified from the soil metagenome...

Nature Chemical Biology, Published online: 22 November 2023; doi:10.1038/s41589-023-01501-4Survival of the sweetest tooth

Nature Chemical Biology, Published online: 22 November 2023; doi:10.1038/s41589-023-01499-9Traffic control