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Nature Communications is an online-only, multidisciplinary journal dedicated to publishing high-quality research in all areas of the biological, physical and chemical sciences. Papers published by the journal represent important advances of significa

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Enhanced dispersion stability of gold nanoparticles by the physisorption of cyclic poly(ethylene glycol)

Nature Communications, Published online: 30 November 2020; doi:10.1038/s41467-020-19947-8Many nanoparticles are stabilised by chemical functionalisation with poly(ethylene glycol) (PEG). Here, the authors report on the functionalisation of gold nanoparticles by the physical absorption of cyclic PEG and demonstrate superior stabilisation against heating,...

Differential guest location by host dynamics enhances propylene/propane separation in a metal-organic framework

Nature Communications, Published online: 30 November 2020; doi:10.1038/s41467-020-19207-9Porous materials acting as molecular sieves for propylene/propane separation are important for the petrochemical industry. Here the authors show an example of how specific guest-host interactions can result in structural changes in the porous host and shut down...

Reply to: “Enhancement of <i>Aedes aegypti</i> susceptibility to dengue by <i>Wolbachia</i> is not supported”

Nature Communications, Published online: 30 November 2020; doi:10.1038/s41467-020-19831-5Reply to: “Enhancement of Aedes aegypti susceptibility to dengue by Wolbachia is not supported”

Enhancement of <i>Aedes aegypti</i> susceptibility to dengue by <i>Wolbachia</i> is not supported

Nature Communications, Published online: 30 November 2020; doi:10.1038/s41467-020-19830-6Enhancement of Aedes aegypti susceptibility to dengue by Wolbachia is not supported

Bedaquiline reprograms central metabolism to reveal glycolytic vulnerability in <i>Mycobacterium tuberculosis</i>

Nature Communications, Published online: 30 November 2020; doi:10.1038/s41467-020-19959-4Bedaquiline (BDQ) is a known tuberculosis treatment, but the precise mechanism of cell death is unclear. Here, the authors explore the metabolic profiles of M. tuberculosis upon BDQ treatment and find reliance on glycolysis and synergistic cell death when oxidative...

Identification of regulators of poly-ADP-ribose polymerase inhibitor response through complementary CRISPR knockout and activation screens

Nature Communications, Published online: 30 November 2020; doi:10.1038/s41467-020-19961-wMutations in the homologous recombination proteins BRCA1 and BRCA2 can sensitize cells to treatment with inhibitors of poly-ADP-ribose polymerase 1 (PARPi), but resistance to the treatment can occur. Here the authors by genome-wide CRISPR knockout and activation...

Chronic neuronal activation increases dynamic microtubules to enhance functional axon regeneration after dorsal root crush injury

Nature Communications, Published online: 30 November 2020; doi:10.1038/s41467-020-19914-3Central axons have limited regenerative ability following injury. Here, the authors show that chronic activation of DRG neurons results in highly dynamic microtubules at the distal axons and enhanced axonal regrowth and synaptogenesis in the spinal cord affecting...

<i>MINPP1</i> prevents intracellular accumulation of the chelator inositol hexakisphosphate and is mutated in Pontocerebellar Hypoplasia

Nature Communications, Published online: 30 November 2020; doi:10.1038/s41467-020-19919-yTight regulation of inositol polyphosphate metabolism is essential for proper cell physiology. Here, the authors describe an early-onset neurodegenerative syndrome caused by loss-of-function mutations in the MINPP1 gene, characterised by intracellular imbalance...

Enhanced dispersion stability of gold nanoparticles by the physisorption of cyclic poly(ethylene glycol)

Differential guest location by host dynamics enhances propylene/propane separation in a metal-organic framework

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