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Nature Communications is an online-only, multidisciplinary journal dedicated to publishing high-quality research in all areas of the biological, physical and chemical sciences. Papers published by the journal represent important advances of significa

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Spatial defects nanoengineering for bipolar conductivity in MoS<sub>2</sub>

Nature Communications, Published online: 10 July 2020; doi:10.1038/s41467-020-17241-1Bipolar conductivity is fundamental for electronic devices based on two-dimensional semiconductors. Here, the authors report on-demand p- and n-doping of monolayer MoS2 via defects engineering using thermochemical scanning probe lithography, and achieve a p-n junction...

Large-scale mass wasting in the western Indian Ocean constrains onset of East African rifting

Nature Communications, Published online: 10 July 2020; doi:10.1038/s41467-020-17267-5The authors describe a huge submarine landslide deposit offshore Tanzania and highlight that large and potentially tsunamigenic landslide events are associated with plateau uplift and continental rifting in East Africa.

Structure of the DOCK2−ELMO1 complex provides insights into regulation of the auto-inhibited state

Nature Communications, Published online: 10 July 2020; doi:10.1038/s41467-020-17271-9DOCK2 is a guanine nucleotide exchange factor (GEF) that activates RHO GTPases and interacts with ELMO1, which stimulates its GEF activity. Here, the authors provide mechanistic insights into how ELMO1 regulates DOCK2 activity by determining the structure of the DOCK2–ELMO1...

Structural basis of seamless excision and specific targeting by <i>piggyBac</i> transposase

Nature Communications, Published online: 10 July 2020; doi:10.1038/s41467-020-17128-1PiggyBac is a transposon used in genome engineering that does not leave excision footprints. Here the authors determine the structures of two complexes in which the piggyBac transposase is bound to DNA representing different steps of the transposition reaction, providing...

A cytoskeleton regulator AVIL drives tumorigenesis in glioblastoma

Nature Communications, Published online: 10 July 2020; doi:10.1038/s41467-020-17279-1Genes that modulate the cytoskeleton have been associated with increased cell proliferation and migration. Here, the authors show that AVIL, an actin regulatory protein, is overexpressed in glioblastomas and mediates oncogenic effects through regulation of FOXM1 stability...

A family of lead clusters with precious metal cores

Nature Communications, Published online: 10 July 2020; doi:10.1038/s41467-020-17187-4Many Zintl ions with a single endohedrally encapsulated transition metal ion are known, but relatively few where clusters of two or more metals are present. Here, the authors report the synthesis and characterization of two clusters, [Au8Pb33]6− and [Au12Pb44]12−, which...

Synucleinopathy alters nanoscale organization and diffusion in the brain extracellular space through hyaluronan remodeling

Nature Communications, Published online: 10 July 2020; doi:10.1038/s41467-020-17328-9The nanoscale organisation of the brain extracellular space can be studied in vivo. Here, the authors investigate how it changes in response to α-synuclein pathology, and identify interactions between microglia and the extracellular matrix.

Mechano-modulatory synthetic niches for liver organoid derivation

Nature Communications, Published online: 10 July 2020; doi:10.1038/s41467-020-17161-03D liver organoids hold great promise for regenerative medicine but the use of ill-defined matrices limits their potential. Here, the authors generate human and mouse liver organoids using a chemically defined matrix, and reveal a link between matrix stiffness and organoid...

Spatial defects nanoengineering for bipolar conductivity in MoS<sub>2</sub>

Large-scale mass wasting in the western Indian Ocean constrains onset of East African rifting

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