Nature Immunology is a multidisciplinary journal that publishes papers of the highest quality and significance in all areas of immunology. Priority is given to work that provides fundamental insight into the workings of the immune system. Areas cover
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A humanized mouse that mounts specific and mature antibody and autoantibody responses

Nature Immunology, Published online: 18 July 2024; doi:10.1038/s41590-024-01908-8We constructed a humanized (THX) mouse by grafting non-γ-irradiated, genetically myeloablated immunodeficient mouse neonates with human cord blood CD34+ cells, followed by 17β-estradiol hormonal conditioning. THX mice develop a human lymphoid and myeloid immune system,...

Thu Jul 18, 2024 13:11
T cell dysfunction and therapeutic intervention in cancer

Nature Immunology, Published online: 18 July 2024; doi:10.1038/s41590-024-01896-9In this Review, the authors analyze functional and dysfunctional T cell features to make sense of cancer immunotherapy efficacy and how to improve it.

Thu Jul 18, 2024 13:11
Gα13 restricts nutrient driven proliferation in mucosal germinal centers

Nature Immunology, Published online: 18 July 2024; doi:10.1038/s41590-024-01910-0Muppidi and colleagues show that loss of Gα13 drives B cell lymphomas preferentially in the mesenteric lymph nodes. They find that Gα13 is required to counteract mTORC1 and Myc signaling that is driven by the availability of dietary glutamine.

Thu Jul 18, 2024 13:11
Chromatin state and BACH2 control T<sub>H</sub>17 cell functional heterogeneity

Nature Immunology, Published online: 17 July 2024; doi:10.1038/s41590-024-01904-yWe performed transcriptional and chromatin accessibility profiling of TH17 cells to distinguish the pathways that regulate pathogenic versus non-pathogenic TH17 cell subsets. We show that TH17 cell functional heterogeneity is linked to distinct regulatory programs that...

Wed Jul 17, 2024 12:48
Vγ9Vδ2 T cells recognize butyrophilin 2A1 and 3A1 heteromers

Nature Immunology, Published online: 16 July 2024; doi:10.1038/s41590-024-01892-zIn this study, Uldrich and colleagues describe the crystal structure of the Vγ9Vδ2 T cell antigen receptor (TCR) interacting with BTN2A1 and demonstrate the existence of a second ligand that co-binds to a distinct epitope on Vγ9Vδ2 TCR. Using these data, the authors suggest...

Tue Jul 16, 2024 12:58
Advancements in pathogen immunity and signaling

Nature Immunology, Published online: 15 July 2024; doi:10.1038/s41590-024-01905-xThe EMBO workshop ‘Pathogen Immunity and Signaling’, held in San Servolo, Italy, from 8 to 12 April 2024, aimed to discuss cutting-edge advances in the understanding of antimicrobial defense mechanisms.

Mon Jul 15, 2024 13:50

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