Nature Immunology, Published online: 26 April 2024; doi:10.1038/s41590-024-01829-6The transient expression of CD61 and its unconventional pairing with CD103 at the immune synapse enhances T cell receptor signaling, improves anti-tumor cytotoxicity and mitigates tumor growth. Clinically, CD61+ tumor infiltrating lymphocytes (TILs) exhibit enhanced effector...

Nature Immunology, Published online: 26 April 2024; doi:10.1038/s41590-024-01830-zIn this study, the authors suggest that in the lung ApoE is a checkpoint for monocyte-to-macrophage differentiation triggered by the dectin1–Card9 pathway.

Nature Immunology, Published online: 25 April 2024; doi:10.1038/s41590-024-01806-zThe microbiome is known to affect antitumor immune responses, but how this occurs is unclear. Rhamnose-rich polysaccharides (RHP) from a commensal strain of Lactiplantibacillus plantarum have now been shown to induce iron sequestration by tumor macrophages, thereby limiting...

Nature Immunology, Published online: 25 April 2024; doi:10.1038/s41590-024-01816-xHere the authors show that a heteropolysaccharide from a commensal bacteria commonly found in the Korean food kimchi is able to bolster antitumor immune responses by instructing tumor-associated macrophages to release lipocalin-2, which sequesters iron away from tumor...

Nature Immunology, Published online: 24 April 2024; doi:10.1038/s41590-024-01804-1Bock and colleagues perform integrative analysis of JAK-STAT mutant mice and find JAK-STAT signaling regulates CD8+ T cell and macrophage homeostasis by contributing to a poised epigenetic and transcription-regulatory state, preparing cells to rapidly respond to stimuli.

Nature Immunology, Published online: 19 April 2024; doi:10.1038/s41590-024-01841-wAuthor Correction: MEF2C regulates NK cell effector functions through control of lipid metabolism