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Nature Medicine is the premier journal for biomedical research. Respected internationally for the quality of its papers on areas ranging from infectious disease to cancer and neurodegeneration, Nature Medicine aims to bridge the gap between basic res

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Caution with AI-generated content in biomedicine

Nature Medicine, Published online: 07 February 2023; doi:10.1038/d41591-023-00014-wGenerative artificial intelligence tools such as chatGPT have many uses in medicine, but a lack of accuracy poses problems.

Prevalence of smoldering multiple myeloma based on nationwide screening

Nature Medicine, Published online: 06 February 2023; doi:10.1038/s41591-022-02183-6A nationwide screening program from the iStopMM study performed in Iceland to detect smoldering multiple myeloma reported a prevalence of 0.5% in individuals over 40 years of age, with increasing risks with age and in males.

Trialing precision medicine for type 2 diabetes

Nature Medicine, Published online: 03 February 2023; doi:10.1038/s41591-022-02168-5A study prospectively evaluating a stratified approach to selecting treatment heralds a new era of precision medicine for type 2 diabetes, which should incorporate ongoing discovery, social determinants of health and healthcare transformation.

American Life in Realtime: a benchmark registry of health data for equitable precision health

Nature Medicine, Published online: 03 February 2023; doi:10.1038/s41591-022-02171-wAmerican Life in Realtime: a benchmark registry of health data for equitable precision health

Implementing clinical trial data sharing requires training a new generation of biomedical researchers

Nature Medicine, Published online: 02 February 2023; doi:10.1038/s41591-022-02080-yData sharing enhances the value of medical research and builds trust in clinical trials, but more biomedical researchers need to be trained in these approaches, which include meta-research, data science and ethical, legal and social issues.

First-line serplulimab or placebo plus chemotherapy in PD-L1-positive esophageal squamous cell carcinoma: a randomized, double-blind phase 3 trial

Nature Medicine, Published online: 02 February 2023; doi:10.1038/s41591-022-02179-2The combination of anti-PD-1 treatment with cisplatin and 5-fluorouracil in patients with previously untreated, PD-L1-positive esophageal squamous cell carcinoma improved progression-free survival and overall survival.

Landscape of pathogenic mutations in premature ovarian insufficiency

Nature Medicine, Published online: 02 February 2023; doi:10.1038/s41591-022-02194-3Whole-exome sequencing analyses in a cohort of 1,030 patients with premature ovarian insufficiency identify new likely pathogenic variants and reveal distinct genetic architectures between primary and secondary amenorrhea.

High- or low-dose preoperative ipilimumab plus nivolumab in stage III urothelial cancer: the phase 1B NABUCCO trial

Nature Medicine, Published online: 02 February 2023; doi:10.1038/s41591-022-02199-yHigh-dose ipilimumab plus nivolumab in locoregionally advanced urothelial cancer led to a higher pathological complete response rate than low-dose ipilimumab in cohort 2. Presurgical absence of plasma (but not urinary) circulating tumor DNA correlated with clinical outcome.

Determinants of COVID-19 vaccination status and hesitancy among older adults in China

Nature Medicine, Published online: 31 January 2023; doi:10.1038/s41591-023-02241-7Analysis of a longitudinal cohort revealed that only 72% of Chinese adults aged over 60 years received booster COVID-19 vaccination by July 2022, with contraindications, advanced age and living with chronic conditions being the main determinants of vaccine hesitancy in...

Seeking therapeutic synergy in <i>BRAF</i> mutant colorectal cancer

Nature Medicine, Published online: 31 January 2023; doi:10.1038/s41591-022-02192-5In a phase I trial, the combination of dabrafenib, trametinib and spartalizumab uncovers the crosstalk between the MAPK pathway and the immune system, which offers a promising new strategy to improve clinical outcomes.

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