Linking human intestinal scaffolds and organoids to combat intestinal failure

Nature Medicine, Published online: 23 September 2020; doi:10.1038/s41591-020-1096-9Combining organoids and decellularized intestinal scaffolds generates durable hybrid intestines that will open up new avenues for the regenerative treatment of patients with intestinal failure.

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The importance of generating more data on cannabis use in pregnancy

Nature Medicine, Published online: 23 September 2020; doi:10.1038/s41591-020-1091-1An increase in cannabis use is inevitable, and the spread of its legalization will probably result in increasing use during pregnancy. A study from Canada uses real-world data to quantify the cognitive effects on offspring of in utero cannabis exposure.

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COVID-19 clinical trials: learning from exceptions in the research chaos

Nature Medicine, Published online: 22 September 2020; doi:10.1038/s41591-020-1077-zCOVID-19 clinical trials: learning from exceptions in the research chaos

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Clustering and superspreading potential of SARS-CoV-2 infections in Hong Kong

Nature Medicine, Published online: 17 September 2020; doi:10.1038/s41591-020-1092-0Cases linked to superspreading events are estimated to account for 80% of all local transmission of SARS-CoV-2 in Hong Kong in a study with implications for public health policies.

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Clustering and superspreading potential of SARS-CoV-2 infections in Hong Kong

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Convalescent plasma treatment of severe COVID-19: a propensity score–matched control study

Nature Medicine, Published online: 15 September 2020; doi:10.1038/s41591-020-1088-9Convalescent plasma for treatment of hospitalized patients with COVID-19 is associated with improved survival in a retrospective comparison with matched controls, supporting further study in randomized controlled trials.

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Convalescent plasma treatment of severe COVID-19: a propensity score–matched control study

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Single-cell transcriptomic atlas of the human endometrium during the menstrual cycle

Nature Medicine, Published online: 14 September 2020; doi:10.1038/s41591-020-1040-zSingle-cell transcriptomics analysis of endometrium samples from healthy women collected across the menstrual cycle provides insights into the cellular and molecular changes surrounding and during the implantation window in the absence of pregnancy.

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Multidimensional transcriptomic mapping of human endometrium at single-cell resolution

Nature Medicine, Published online: 14 September 2020; doi:10.1038/s41591-020-1075-1Single-cell RNA sequencing across the menstrual cycle reveals human endometrial cell–specific preparation for embryo implantation, menstruation and tissue renewal.

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Production, safety and efficacy of iPSC-derived mesenchymal stromal cells in acute steroid-resistant graft versus host disease: a phase I, multicenter, open-label, dose-escalation study

Nature Medicine, Published online: 14 September 2020; doi:10.1038/s41591-020-1050-xA GMP-compliant process for generating human iPSC-derived mesenchymal stromal cells tested in a phase 1 trial is safe and well tolerated in subjects with acute steroid-resistant graft versus host disease.

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