Caution with AI-generated content in biomedicine

Nature Medicine, Published online: 07 February 2023; doi:10.1038/d41591-023-00014-wGenerative artificial intelligence tools such as chatGPT have many uses in medicine, but a lack of accuracy poses problems.

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Prevalence of smoldering multiple myeloma based on nationwide screening

Nature Medicine, Published online: 06 February 2023; doi:10.1038/s41591-022-02183-6A nationwide screening program from the iStopMM study performed in Iceland to detect smoldering multiple myeloma reported a prevalence of 0.5% in individuals over 40 years of age, with increasing risks with age and in males.

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Trialing precision medicine for type 2 diabetes

Nature Medicine, Published online: 03 February 2023; doi:10.1038/s41591-022-02168-5A study prospectively evaluating a stratified approach to selecting treatment heralds a new era of precision medicine for type 2 diabetes, which should incorporate ongoing discovery, social determinants of health and healthcare transformation.

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American Life in Realtime: a benchmark registry of health data for equitable precision health

Nature Medicine, Published online: 03 February 2023; doi:10.1038/s41591-022-02171-wAmerican Life in Realtime: a benchmark registry of health data for equitable precision health

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Implementing clinical trial data sharing requires training a new generation of biomedical researchers

Nature Medicine, Published online: 02 February 2023; doi:10.1038/s41591-022-02080-yData sharing enhances the value of medical research and builds trust in clinical trials, but more biomedical researchers need to be trained in these approaches, which include meta-research, data science and ethical, legal and social issues.

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First-line serplulimab or placebo plus chemotherapy in PD-L1-positive esophageal squamous cell carcinoma: a randomized, double-blind phase 3 trial

Nature Medicine, Published online: 02 February 2023; doi:10.1038/s41591-022-02179-2The combination of anti-PD-1 treatment with cisplatin and 5-fluorouracil in patients with previously untreated, PD-L1-positive esophageal squamous cell carcinoma improved progression-free survival and overall survival.

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Landscape of pathogenic mutations in premature ovarian insufficiency

Nature Medicine, Published online: 02 February 2023; doi:10.1038/s41591-022-02194-3Whole-exome sequencing analyses in a cohort of 1,030 patients with premature ovarian insufficiency identify new likely pathogenic variants and reveal distinct genetic architectures between primary and secondary amenorrhea.

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High- or low-dose preoperative ipilimumab plus nivolumab in stage III urothelial cancer: the phase 1B NABUCCO trial

Nature Medicine, Published online: 02 February 2023; doi:10.1038/s41591-022-02199-yHigh-dose ipilimumab plus nivolumab in locoregionally advanced urothelial cancer led to a higher pathological complete response rate than low-dose ipilimumab in cohort 2. Presurgical absence of plasma (but not urinary) circulating tumor DNA correlated with clinical outcome.

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Determinants of COVID-19 vaccination status and hesitancy among older adults in China

Nature Medicine, Published online: 31 January 2023; doi:10.1038/s41591-023-02241-7Analysis of a longitudinal cohort revealed that only 72% of Chinese adults aged over 60 years received booster COVID-19 vaccination by July 2022, with contraindications, advanced age and living with chronic conditions being the main determinants of vaccine hesitancy in...

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Seeking therapeutic synergy in <i>BRAF</i> mutant colorectal cancer

Nature Medicine, Published online: 31 January 2023; doi:10.1038/s41591-022-02192-5In a phase I trial, the combination of dabrafenib, trametinib and spartalizumab uncovers the crosstalk between the MAPK pathway and the immune system, which offers a promising new strategy to improve clinical outcomes.

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