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In vivo functional screening for systems-level integrative cancer genomics

Nature Reviews Cancer, Published online: 07 July 2020; doi:10.1038/s41568-020-0275-9This Review discusses functional screening strategies in mice, which use genetic perturbation or chemical mutagenesis to delineate genomic and regulatory features in oncogenesis, metastasis and drug resistance, which might in turn help to identify targetable cancer vulnerabilities.

Metabolites going up in smoke

Nature Reviews Cancer, Published online: 07 July 2020; doi:10.1038/s41568-020-0289-3Using a rapid mass-spectrometry based approach to analyse aerosol released during surgical cauterization of tumour tissue, Koundouros et al. derived metabolic signatures associated with the tumour genotype. Based on these signatures, they identified a new mechanism by...

In vivo functional screening for systems-level integrative cancer genomics

Metabolites going up in smoke

Metabolism of immune cells in cancer

Nature Reviews Cancer, Published online: 06 July 2020; doi:10.1038/s41568-020-0273-yThis Review discusses our current understanding of adaptive and innate immune cell metabolism in the context of the tumour microenvironment, providing insight into the interaction of cancer cell metabolism and immune metabolism, as well as the potential for leveraging...

Metabolism of immune cells in cancer

Tumours disrupt the immune scenery

Nature Reviews Cancer, Published online: 03 July 2020; doi:10.1038/s41568-020-0286-6Allen, Hiam et al. have used mass cytometry to characterize the immune landscape over time in response to tumour development, demonstrating that tumour growth dynamically alters the systemic immune landscape and that this can be reverted by tumour removal.

Tumours disrupt the immune scenery

Integrating serine with tumour initiation

Integrating serine with tumour initiation

Nature Reviews Cancer, Published online: 01 July 2020; doi:10.1038/s41568-020-0287-5Baksh et al. have delineated a pathway through which serine availability is integrated with stem cell fate decisions and can control the initiation of epidermal squamous cell carcinomas.

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