Improving human cancer therapy through the evaluation of pet dogs

5d

Improving human cancer therapy through the evaluation of pet dogs

Nature Reviews Cancer, Published online: 15 September 2020; doi:10.1038/s41568-020-0297-3This Review discusses the role of comparative oncology studies between pet dogs and humans with an emphasis on selected canine tumour types that represent those with the most translational benefit to humans and those possessing important molecular intersections...

5d

Compartmental reorganization suppresses tumours

Nature Reviews Cancer, Published online: 15 September 2020; doi:10.1038/s41568-020-00305-1Johnstone, Reyes et al. find that colorectal cancer cells undergo substantial compartmental reorganization and that this likely supresses, rather than promotes, tumorigenesis.

5d

Compartmental reorganization suppresses tumours

5d

Sexual dimorphism in cancer

Nature Reviews Cancer, Published online: 11 September 2020; doi:10.1038/s41568-020-00304-2Two studies have now provided evidence of differences, dependent on patient sex, in oncogenic features, such as frequencies of driver gene mutations, mutation load and mutational signatures, as well as immune selection.

2w

Sexual dimorphism in cancer

2w

Hyperinsulinaemia in cancer

Nature Reviews Cancer, Published online: 09 September 2020; doi:10.1038/s41568-020-0295-5This Review discusses the current understanding of how insulin and insulin receptor signalling contribute to cancer growth, in the context of the rising prevalence of obesity and diabetes worldwide and the realization that hyperinsulinaemia may contribute to therapeutic...

2w

Hyperinsulinaemia in cancer

2w

Metabolic rivalry: circadian homeostasis and tumorigenesis

Nature Reviews Cancer, Published online: 07 September 2020; doi:10.1038/s41568-020-0291-9Perturbations of circadian rhythms can promote cancer, and expression of core clock genes and proteins is attenuated in many tumours. Furthermore, metabolic control by the circadian clock may influence cancer metabolism. This Review outlines recent discoveries related...

2w

Metabolic rivalry: circadian homeostasis and tumorigenesis

2w