Advances in bladder cancer biology and therapy

Nature Reviews Cancer, Published online: 02 December 2020; doi:10.1038/s41568-020-00313-1This Review examines recent developments in the molecular and translational aspects of bladder cancer biology and discusses their current or potential future clinical applications in the management of bladder cancer.

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Advances in bladder cancer biology and therapy

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Tracing the origins of <i>KRAS</i> oncogene addiction

Nature Reviews Cancer, Published online: 01 December 2020; doi:10.1038/s41568-020-00325-xLi, He and Peng et al. show how pancreatic inflammation and KRAS mutation cooperate to initiate neoplasia in a transient progenitor cell population.

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The neuronal-metabolic interface

Nature Reviews Cancer, Published online: 01 December 2020; doi:10.1038/s41568-020-00324-yBanh et al. show that peripheral axons of sensory nerves release serine into the tumour microenvironment, which can support the growth of extracellular serine-dependent pancreatic ductal adenocarcinoma by promoting mRNA translation.

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Tracing the origins of <i>KRAS</i> oncogene addiction

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The neuronal-metabolic interface

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Endoplasmic reticulum stress signals in the tumour and its microenvironment

Nature Reviews Cancer, Published online: 19 November 2020; doi:10.1038/s41568-020-00312-2The hostile microenvironment of the tumour can disrupt endoplasmic reticulum (ER) homeostasis in cancer cells and infiltrating immune cells to result in a state of ER stress. This Review discusses how ER stress can influence not only the pro-tumoural features of...

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Endoplasmic reticulum stress signals in the tumour and its microenvironment

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Addressing the mental health crisis

Nature Reviews Cancer, Published online: 17 November 2020; doi:10.1038/s41568-020-00319-9There is evidence of a mounting mental health crisis among researchers, which may be exacerbated by the COVID-19 pandemic. This Comment article discusses what cancer researchers and institutions can do to promote good mental health and wellbeing within their research...

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Addressing the mental health crisis

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