Harnessing multimodal data integration to advance precision oncology

Nature Reviews Cancer, Published online: 18 October 2021; doi:10.1038/s41568-021-00408-3This Perspective proposes that data from multiple modalities, including molecular diagnostics, radiological and histological imaging and codified clinical data, should be integrated by multimodal machine learning models to advance the prognosis and treatment management...

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Harnessing multimodal data integration to advance precision oncology

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The manipulation of apoptosis for cancer therapy using BH3-mimetic drugs

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The manipulation of apoptosis for cancer therapy using BH3-mimetic drugs

Nature Reviews Cancer, Published online: 18 October 2021; doi:10.1038/s41568-021-00407-4BH3-mimetic drugs have been designed to directly induce apoptosis in cancer cells by targeting prosurvival BCL-2 family proteins. This Review discusses their continued development and the challenges arising from their implementation in the clinic, such as resistance...

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New targets in triple-negative breast cancer

Nature Reviews Cancer, Published online: 07 October 2021; doi:10.1038/s41568-021-00415-4In this Journal Club, Robert L. Copeland and Yasmine Kanaan discuss a paper that reports how ERβ and IGF2 signalling may contribute to the heterogeneity of triple-negative breast cancer observed in patients with different ancestries in the USA.

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New targets in triple-negative breast cancer

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Under pressure

Nature Reviews Cancer, Published online: 05 October 2021; doi:10.1038/s41568-021-00416-3Two recent studies have found that both the adaptive immune system and inflammation can drive the selection of cells carrying mutations that facilitate tumour initiation.

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Bringing community to our pages

Nature Reviews Cancer, Published online: 05 October 2021; doi:10.1038/s41568-021-00414-5In an effort to bring to our pages some of the vibrant discussion of cancer research that happens during in-person or online journal club meetings, we are now publishing Journal Clubs — an article type in which researchers discuss research papers of their choice...

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Under pressure

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Bringing community to our pages

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