T cell drivers in NASH-HCC

Nature Reviews Cancer, Published online: 16 April 2021; doi:10.1038/s41568-021-00362-0Pfister et al. demonstrate a role for unconventionally activated CD8+PD1+ T cells in NASH-HCC, which limits response to immunotherapy.

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T cell drivers in NASH-HCC

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Bacteria prepare the niche

Nature Reviews Cancer, Published online: 15 April 2021; doi:10.1038/s41568-021-00361-1Bertocchi et al. show that tumour-resident bacteria in colorectal cancer disseminate to the liver via an impaired gut vascular barrier and promote the liver pre-metastatic niche.

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Bacteria prepare the niche

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Mechanosurveillance of tumour metastasis

Nature Reviews Cancer, Published online: 14 April 2021; doi:10.1038/s41568-021-00360-2Tello-Lafoz et al. find that the increased rigidity of cancer cells during metastasis can result in a biophysical vulnerability to killing by cytotoxic lymphocytes through a form of mechanosurveillance.

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Mechanosurveillance of tumour metastasis

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Promoting cancer genomics research in Africa: a roadmap

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Promoting cancer genomics research in Africa: a roadmap

Nature Reviews Cancer, Published online: 12 April 2021; doi:10.1038/s41568-021-00359-9Cancer genomics research in Africa is crucial to understanding the genetic architecture of cancer and tailoring cancer diagnoses and therapies to African populations. Creating this research enterprise in Africa has to be purposeful with a roadmap that incorporates...

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Systemic immunity in cancer

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Systemic immunity in cancer

Nature Reviews Cancer, Published online: 09 April 2021; doi:10.1038/s41568-021-00347-zAn improved understanding of tumour immunology and therapy must assess the systemic immune landscape beyond the tumour microenvironment. This Review outlines peripheral immune cell reorganization in response to tumour growth and therapy, their contribution to immunotherapy...

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