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T cells feed into cancer immune escape

Nature Reviews Cancer, Published online: 02 February 2023; doi:10.1038/s41568-023-00550-0This study shows how the selective immune pressure in early-stage tumours drives interferon-γ-dependent metabolic reprogramming in cancer cells to mediate immune escape.

Mechanisms driving the immunoregulatory function of cancer cells

Nature Reviews Cancer, Published online: 30 January 2023; doi:10.1038/s41568-022-00544-4This Review outlines how the profound intertumoural heterogeneity in immune landscapes of tumours is shaped by cancer cell-intrinsic alterations and highlights how the crosstalk between these two continuously evolving systems not only challenges therapy success of...

Acetyl-CoA metabolism in cancer

Nature Reviews Cancer, Published online: 19 January 2023; doi:10.1038/s41568-022-00543-5Acetyl coenzyme A (acetyl-CoA) is a key metabolite in carbohydrate and lipid metabolism and plays a role in signalling through protein acetylation, and the dysregulation of these pathways is a hallmark of various cancers. In this Review, Guertin and Wellen give an...

Leptin fuels non-genetic skin tumour progression

Nature Reviews Cancer, Published online: 11 January 2023; doi:10.1038/s41568-023-00548-8To understand malignant progression, Yuan et al. delineate the complex crosstalk between cancer stem cells and their microenvironment that is initiated by oncogenic RAS.

RNA splicing dysregulation and the hallmarks of cancer

Nature Reviews Cancer, Published online: 10 January 2023; doi:10.1038/s41568-022-00541-7This Review discusses the diverse ways in which cancer-associated RNA splicing dysregulation promotes tumour initiation and progression, existing and emerging approaches for targeting splicing for cancer therapy and outstanding questions and challenges in the field.

STAT proteins in cancer: orchestration of metabolism

Nature Reviews Cancer, Published online: 03 January 2023; doi:10.1038/s41568-022-00537-3Reprogrammed metabolism is a hallmark of cancer. Here, Li, Zhang and colleagues describe how signal transducer and activator of transcription (STAT) proteins alter cancer cell metabolism by sensing and transducing signals from the tumour environment and modulating...

Dendritic cells rise and shine

Nature Reviews Cancer, Published online: 21 December 2022; doi:10.1038/s41568-022-00545-3In a study in Nature, Wang et al. describe how circadian rhythms can impact tumour suppression through their effects on dendritic cells, a finding that could help to optimize clinical trials of cancer immunotherapies.

Author Correction: Learning to distinguish progressive and non-progressive ductal carcinoma in situ

Nature Reviews Cancer, Published online: 15 December 2022; doi:10.1038/s41568-022-00542-6Author Correction: Learning to distinguish progressive and non-progressive ductal carcinoma in situ

Biology, vulnerabilities and clinical applications of circulating tumour cells

Nature Reviews Cancer, Published online: 09 December 2022; doi:10.1038/s41568-022-00536-4As well-established players in the metastatic cascade, circulating tumour cells (CTCs) hold promise for improved cancer diagnosis and disease monitoring. In this Review, Ring et al. overview the current understanding of CTC biology, highlighting specific opportunities...

Targeting DNA damage response pathways in cancer

Nature Reviews Cancer, Published online: 05 December 2022; doi:10.1038/s41568-022-00535-5Genes encoding DNA damage response factors are frequently mutated in cancer, causing genomic instability and presenting opportunities for therapeutic intervention. This Review discusses state-of-the-art strategies for DNA damage response inactivation using small-molecule...

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