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Advances in bladder cancer biology and therapy

Nature Reviews Cancer, Published online: 02 December 2020; doi:10.1038/s41568-020-00313-1This Review examines recent developments in the molecular and translational aspects of bladder cancer biology and discusses their current or potential future clinical applications in the management of bladder cancer.

Advances in bladder cancer biology and therapy

Tracing the origins of <i>KRAS</i> oncogene addiction

Nature Reviews Cancer, Published online: 01 December 2020; doi:10.1038/s41568-020-00325-xLi, He and Peng et al. show how pancreatic inflammation and KRAS mutation cooperate to initiate neoplasia in a transient progenitor cell population.

The neuronal-metabolic interface

Nature Reviews Cancer, Published online: 01 December 2020; doi:10.1038/s41568-020-00324-yBanh et al. show that peripheral axons of sensory nerves release serine into the tumour microenvironment, which can support the growth of extracellular serine-dependent pancreatic ductal adenocarcinoma by promoting mRNA translation.

Tracing the origins of <i>KRAS</i> oncogene addiction

The neuronal-metabolic interface

Endoplasmic reticulum stress signals in the tumour and its microenvironment

Nature Reviews Cancer, Published online: 19 November 2020; doi:10.1038/s41568-020-00312-2The hostile microenvironment of the tumour can disrupt endoplasmic reticulum (ER) homeostasis in cancer cells and infiltrating immune cells to result in a state of ER stress. This Review discusses how ER stress can influence not only the pro-tumoural features of...

Endoplasmic reticulum stress signals in the tumour and its microenvironment

Addressing the mental health crisis

Nature Reviews Cancer, Published online: 17 November 2020; doi:10.1038/s41568-020-00319-9There is evidence of a mounting mental health crisis among researchers, which may be exacerbated by the COVID-19 pandemic. This Comment article discusses what cancer researchers and institutions can do to promote good mental health and wellbeing within their research...

Addressing the mental health crisis

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