Nature Reviews Cancer, Published online: 24 July 2024; doi:10.1038/s41568-024-00729-zLeighow et al. develop a strategy called the dual-switch selection gene drive platform, which enables the evolutionary dynamics of acquired resistance to be manipulated for therapeutic ends.

Nature Reviews Cancer, Published online: 24 July 2024; doi:10.1038/s41568-024-00723-5Adoptive cell therapies have emerged as promising approaches for the treatment of patients with cancer. Engineering cell therapies to confer resistance to small-molecule therapies, chemotherapies and antibody-based therapies will improve their utility and success. Here,...

Nature Reviews Cancer, Published online: 22 July 2024; doi:10.1038/s41568-024-00725-3Sex matters in metastasis, but it has received little attention in research. Here, we highlight the emerging and important roles of biological sex in metastasis and advocate for mechanistic and quantitative studies for the future development of sex-tailored therapies.