Digging for treasures in the tumour interactome

Nature Reviews Cancer, Published online: 18 May 2022; doi:10.1038/s41568-022-00487-wIn this Tools of the Trade article, Amir Giladi describes the development and use of PIC-seq, which enables the direct enrichment and analysis of conjugates of physically interacting cells in the tumour microenvironment.

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Digging for treasures in the tumour interactome

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Tools for the next generation

Nature Reviews Cancer, Published online: 10 May 2022; doi:10.1038/s41568-022-00484-zThis month, Nature Reviews Cancer launches Tools of the Trade articles, in which early career researchers can discuss the methods or techniques that they use to conduct their research.

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Tools for the next generation

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Hunting down rare drug-tolerant cycling cells with Watermelon

Nature Reviews Cancer, Published online: 10 May 2022; doi:10.1038/s41568-022-00483-0In this Tools of the Trade article, Yaara Oren describes the development and use of the Watermelon system to simultaneously track the lineage, transcriptional profile and proliferative state of each cancer cell in a population, which enables the characterization of rare...

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Hunting down rare drug-tolerant cycling cells with Watermelon

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An inhospitable site

Nature Reviews Cancer, Published online: 29 April 2022; doi:10.1038/s41568-022-00482-1Crist et al. set out to investigate what makes the colonization of skeletal muscle by disseminated tumour cells (DTCs) so rare and found that this niche enforces persistent oxidative stress on DTCs that cannot be overcome and therefore, restrains their proliferation.

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Disconnecting multicellular networks in brain tumours

Nature Reviews Cancer, Published online: 29 April 2022; doi:10.1038/s41568-022-00475-0This Perspective discusses the role of multicellular tumour networks, formed by tumour microtubes and tunnelling nanotubes, in brain tumours. It also discusses their relevance to therapy resistance and how these networks might be therapeutically targeted, and their...

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An inhospitable site

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Disconnecting multicellular networks in brain tumours

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