Nature Reviews Cancer, Published online: 04 October 2024; doi:10.1038/s41568-024-00762-yCiwinska et al. asked whether natural tissue remodelling can drive mutant cell expansion and identified three protective mechanisms in the healthy mouse mammary gland that constrain the ability of mutant cells to transform and give rise to cancer.

Nature Reviews Cancer, Published online: 01 October 2024; doi:10.1038/s41568-024-00743-1Metabolic disorders, such as obesity, metabolic dysfunction-associated steatotic liver disease (MASLD), metabolic dysfunction-associated steatohepatitis (MASH) and type 2 diabetes, are increasingly recognized as significant contributors to cancer development. Here,...

Nature Reviews Cancer, Published online: 01 October 2024; doi:10.1038/s41568-024-00758-8CRISPR screens in cell cultures reveal cancer dependencies yet often miss the metabolic nuances of tissues. In this Comment, Zuber and Palm highlight how modelling tumour-specific metabolic conditions can enhance our understanding of cancer biology and improve therapeutic...