Nature Reviews Cancer, Published online: 22 April 2024; doi:10.1038/s41568-024-00692-9In this Tools of the Trade article, Daniel Kirschenbaum describes the development of Zman-seq and its utility for capturing dynamic changes in cellular state within single-cell RNA sequencing data.

Nature Reviews Cancer, Published online: 16 April 2024; doi:10.1038/s41568-024-00679-6In this Review, Cichowski and colleagues provide an overview of combinatorial strategies designed to treat RAS-driven cancers that are based on four concepts that include vertical pathway inhibition, co-targeting RAS and adaptive survival pathways, co-targeting downstream...

Nature Reviews Cancer, Published online: 16 April 2024; doi:10.1038/s41568-024-00685-8Generalist medical artificial intelligence (GMAI) models are gaining momentum in their applications for cancer treatment. In this Comment, Gilbert and Kather advocate for novel regulation of GMAI approaches to ensure patient safety and adequate physician support.