Pharmaceutical innovation sourcing

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Pharmaceutical innovation sourcing

Nature Reviews Drug Discovery, Published online: 12 August 2022; doi:10.1038/d41573-022-00125-yPharmaceutical innovation sourcing

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The UK Biobank at 20

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The UK Biobank at 20

Nature Reviews Drug Discovery, Published online: 11 August 2022; doi:10.1038/d41573-022-00137-8The UK Biobank houses an extensive collection of biological samples and health information from 500,000 volunteers, providing clues to the genetic and environmental drivers of disease. Naomi Allen, the project’s chief scientist and an epidemiologist at Oxford...

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The glymphatic system: implications for drugs for central nervous system diseases

Nature Reviews Drug Discovery, Published online: 10 August 2022; doi:10.1038/s41573-022-00500-9Evidence for a fluid clearance pathway in the central nervous system known as the glymphatic system has grown in the past decade. Nedergaard and colleagues overview the evidence for the glymphatic system and its role in disease, and discuss opportunities to...

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The glymphatic system: implications for drugs for central nervous system diseases

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Targeting RNA structures with small molecules

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Targeting RNA structures with small molecules

Nature Reviews Drug Discovery, Published online: 08 August 2022; doi:10.1038/s41573-022-00521-4The potential of therapeutically targeting RNA structures with small molecules is being increasingly recognized. Here, Disney and colleagues review strategies to identify, validate and optimize small-molecule RNA binders. Examples of existing RNA-targeted...

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BCMA-targeted bispecific gets first green light, in the EU

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Biogen files ALS drug for FDA review, putting neuroscience-accelerated approvals back in the hot seat

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