Nature Reviews Drug Discovery, Published online: 24 January 2023; doi:10.1038/s41573-022-00618-wDysregulated protein phosphorylation is implicated in numerous human diseases, but targeting protein phosphates has traditionally proved challenging. Here, Stanford and Bottini provide an overview of protein phosphatase families, focusing on their roles in...
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Nature Reviews Drug Discovery, Published online: 23 January 2023; doi:10.1038/d41573-023-00015-xClinic-ready inhibitors, degraders and molecular glues are pushing cancer frontiers by targeting KRAS variants including KRAS-G12D.
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Nature Reviews Drug Discovery, Published online: 23 January 2023; doi:10.1038/d41573-023-00017-9The non-small-cell lung cancer drug market
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Nature Reviews Drug Discovery, Published online: 18 January 2023; doi:10.1038/d41573-023-00016-wStopping stellate cell communication reverses fibrosis
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Nature Reviews Drug Discovery, Published online: 16 January 2023; doi:10.1038/d41573-023-00014-yError-corrected next-generation sequencing (ecNGS) is an emerging technology with the potential to revolutionize the field of genetic toxicology. Here, we present recommendations from an expert working group convened to discuss potential applications, advantages...
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Nature Reviews Drug Discovery, Published online: 13 January 2023; doi:10.1038/d41573-023-00007-x2022 FDA approval number dips: a COVID-19 hangover?
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Nature Reviews Drug Discovery, Published online: 11 January 2023; doi:10.1038/d41573-023-00013-zAn mRNA universal vaccine for influenza
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Nature Reviews Drug Discovery, Published online: 11 January 2023; doi:10.1038/d41573-023-00012-0Biopharma dealmaking in 2022
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Nature Reviews Drug Discovery, Published online: 11 January 2023; doi:10.1038/d41573-023-00008-wGene editing addresses antithrombin deficiency
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Nature Reviews Drug Discovery, Published online: 11 January 2023; doi:10.1038/d41573-023-00010-2Synthetic cytokine circuit targets solid tumours
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