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Nature Reviews Drug Discovery, Published online: 12 August 2022; doi:10.1038/d41573-022-00125-yPharmaceutical innovation sourcing
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Nature Reviews Drug Discovery, Published online: 11 August 2022; doi:10.1038/d41573-022-00137-8The UK Biobank houses an extensive collection of biological samples and health information from 500,000 volunteers, providing clues to the genetic and environmental drivers of disease. Naomi Allen, the project’s chief scientist and an epidemiologist at Oxford...
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Nature Reviews Drug Discovery, Published online: 10 August 2022; doi:10.1038/s41573-022-00500-9Evidence for a fluid clearance pathway in the central nervous system known as the glymphatic system has grown in the past decade. Nedergaard and colleagues overview the evidence for the glymphatic system and its role in disease, and discuss opportunities to...
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Nature Reviews Drug Discovery, Published online: 08 August 2022; doi:10.1038/s41573-022-00521-4The potential of therapeutically targeting RNA structures with small molecules is being increasingly recognized. Here, Disney and colleagues review strategies to identify, validate and optimize small-molecule RNA binders. Examples of existing RNA-targeted...
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