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Targeting protein phosphatases in cancer immunotherapy and autoimmune disorders

Nature Reviews Drug Discovery, Published online: 24 January 2023; doi:10.1038/s41573-022-00618-wDysregulated protein phosphorylation is implicated in numerous human diseases, but targeting protein phosphates has traditionally proved challenging. Here, Stanford and Bottini provide an overview of protein phosphatase families, focusing on their roles in...

The KRAS crowd targets its next cancer mutations

Nature Reviews Drug Discovery, Published online: 23 January 2023; doi:10.1038/d41573-023-00015-xClinic-ready inhibitors, degraders and molecular glues are pushing cancer frontiers by targeting KRAS variants including KRAS-G12D.

The non-small-cell lung cancer drug market

Nature Reviews Drug Discovery, Published online: 23 January 2023; doi:10.1038/d41573-023-00017-9The non-small-cell lung cancer drug market

Stopping stellate cell communication reverses fibrosis

Nature Reviews Drug Discovery, Published online: 18 January 2023; doi:10.1038/d41573-023-00016-wStopping stellate cell communication reverses fibrosis

Error-corrected next-generation sequencing to advance nonclinical genotoxicity and carcinogenicity testing

Nature Reviews Drug Discovery, Published online: 16 January 2023; doi:10.1038/d41573-023-00014-yError-corrected next-generation sequencing (ecNGS) is an emerging technology with the potential to revolutionize the field of genetic toxicology. Here, we present recommendations from an expert working group convened to discuss potential applications, advantages...

2022 FDA approval number dips: a COVID-19 hangover?

Nature Reviews Drug Discovery, Published online: 13 January 2023; doi:10.1038/d41573-023-00007-x2022 FDA approval number dips: a COVID-19 hangover?

An mRNA universal vaccine for influenza

Nature Reviews Drug Discovery, Published online: 11 January 2023; doi:10.1038/d41573-023-00013-zAn mRNA universal vaccine for influenza

Biopharma dealmaking in 2022

Nature Reviews Drug Discovery, Published online: 11 January 2023; doi:10.1038/d41573-023-00012-0Biopharma dealmaking in 2022

Gene editing addresses antithrombin deficiency

Nature Reviews Drug Discovery, Published online: 11 January 2023; doi:10.1038/d41573-023-00008-wGene editing addresses antithrombin deficiency

Synthetic cytokine circuit targets solid tumours

Nature Reviews Drug Discovery, Published online: 11 January 2023; doi:10.1038/d41573-023-00010-2Synthetic cytokine circuit targets solid tumours

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