Nature Reviews Genetics, Published online: 24 April 2024; doi:10.1038/s41576-024-00720-2Targeted genome modification using CRISPR–Cas genome editing, base editing or prime editing is driving base research in plants and precise molecular breeding. The authors review the technological principles underlying these methods, approaches for their delivery...

Nature Reviews Genetics, Published online: 24 April 2024; doi:10.1038/s41576-024-00733-xIn this Journal Club article, Olivia Rissland describes how a 1987 paper by Don Cleveland and colleagues provided insight into co-translational gene regulation of tubulin.

Nature Reviews Genetics, Published online: 22 April 2024; doi:10.1038/s41576-024-00718-wIn this Review, Li and Durbin discuss how to generate telomere-to-telomere assemblies for large haploid or diploid genomes using currently available data types and algorithms, and outline remaining challenges in resolving highly repetitive sequences and polyploid...

Nature Reviews Genetics, Published online: 18 April 2024; doi:10.1038/s41576-024-00712-2In this Review, the authors summarize our current understanding of nuclear pre-mRNA and mRNA decay pathways. They describe how aberrantly processed mRNAs are targeted for decay in the nucleus and how this process is regulated to finely control gene expression.

Nature Reviews Genetics, Published online: 17 April 2024; doi:10.1038/s41576-024-00723-zIn this Perspective, Werner and colleagues discuss the many potential mechanisms by which natural antisense transcripts (NATs) can regulate expression of their complementary sense transcripts, the biological implications of their regulatory effects and the potential...

Nature Reviews Genetics, Published online: 15 April 2024; doi:10.1038/s41576-024-00732-yIn this Journal Club article, Jenny Tung reflects on a 1975 paper from King and Wilson that emphasized the importance of gene regulatory changes in human evolution.