Nature Reviews Genetics, Published online: 22 July 2024; doi:10.1038/s41576-024-00765-3Neumann, Bertozzi et al. describe a novel epigenetic editor termed CHARM and report its use to silence prion protein expression in the brain.

Nature Reviews Genetics, Published online: 18 July 2024; doi:10.1038/s41576-024-00757-3Advances in genomic technologies have enabled investigations into a wide range of species. In this Review, the authors describe recent studies in both non-model and model organisms that illustrate the diversity of animal sex chromosomes with respect to their evolutionary...

Nature Reviews Genetics, Published online: 12 July 2024; doi:10.1038/s41576-024-00763-5Two studies in Nature reveal the mechanistic and structural properties of a family of mobile genetic elements that can be reprogrammed to engineer genome modifications.

Nature Reviews Genetics, Published online: 09 July 2024; doi:10.1038/s41576-024-00749-3RNA-binding proteins regulate the lifecycle of RNA, and their dysregulation is associated with diseases such as cancer and neurodegeneration. Using methods based on ultraviolet crosslinking followed by immunoprecipitation (CLIP), we can now begin to decode the mechanisms...

Nature Reviews Genetics, Published online: 09 July 2024; doi:10.1038/s41576-024-00764-4Publisher Correction: How germ granules promote germ cell fate

Nature Reviews Genetics, Published online: 05 July 2024; doi:10.1038/s41576-024-00758-2In this Tools of the Trade article, Andrey Tvardovskiy and Saulius Lukauskas introduce the web resource MARCS, which offers a set of visualization tools to explore chromatin regulatory circuits from either a protein- or modification-centred perspective.