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Copy-number classifiers for cancer

Nature Reviews Genetics, Published online: 28 June 2022; doi:10.1038/s41576-022-00516-2Two new papers in Nature report copy-number-based classification systems across cancer types that provide routes for personalized therapy.

Copy-number classifiers for cancer

Genome-scale single-cell CRISPR screens

Nature Reviews Genetics, Published online: 27 June 2022; doi:10.1038/s41576-022-00517-1A report in Cell takes single-cell CRISPR screens to genome scale and demonstrates how the transcriptional phenotypes can be used to resolve gene functions.

Genome-scale single-cell CRISPR screens

Measuring biological age using omics data

Nature Reviews Genetics, Published online: 17 June 2022; doi:10.1038/s41576-022-00511-7Molecular measures of biological ageing based on high-throughput omics technologies are enabling the quantitative characterization of ageing. The authors review how epigenomic, transcriptomic, proteomic, metabolomic and other omics data can be harnessed using machine...

Measuring biological age using omics data

Unpacking race and ethnicity in African genomics research

Unpacking race and ethnicity in African genomics research

Nature Reviews Genetics, Published online: 10 June 2022; doi:10.1038/s41576-022-00506-4In this Comment, the authors highlight caveats about using African ethnicities as population categories in genomics research and emphasize the need for an Africa-oriented humanities research agenda to inform genomics research.

tRNA dysregulation and disease

Context-specific Polycomb mechanisms in development

Nature Reviews Genetics, Published online: 09 June 2022; doi:10.1038/s41576-022-00499-0In this Review, Kim and Kingston discuss the compositional and mechanistic diversity of Polycomb repressive complexes (PRCs) and how their context-dependent formation may be required for proper epigenetic regulation in development.

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