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Understanding human uniqueness in the pre-genomic era

Nature Reviews Genetics, Published online: 15 April 2024; doi:10.1038/s41576-024-00732-yIn this Journal Club article, Jenny Tung reflects on a 1975 paper from King and Wilson that emphasized the importance of gene regulatory changes in human evolution.

Mon Apr 15, 2024 17:39
A developmental exit from totipotency

Nature Reviews Genetics, Published online: 12 April 2024; doi:10.1038/s41576-024-00730-0A paper in Nature Genetics identifies a mechanism involving the transcription factor DUXBL that controls the development of early embryonic mouse cells past stages marked by totipotency.

Fri Apr 12, 2024 22:27
SIMPLE-seq to decode DNA methylation dynamics in single cells

Nature Reviews Genetics, Published online: 12 April 2024; doi:10.1038/s41576-024-00729-7In this Tools of the Trade article, Dongsheng Bai and Chenxu Zhu describe SIMPLE-seq, a scalable single-cell sequencing method that simultaneously decodes the cytosine modifications 5mC and 5hmC.

Fri Apr 12, 2024 22:27
Human embryonic genetic mosaicism and its effects on development and disease

Nature Reviews Genetics, Published online: 11 April 2024; doi:10.1038/s41576-024-00715-zGenetic variants acquired early during embryogenesis can affect numerous tissues. The authors review the phenomenon of embryonic mosaicism, with a focus on small variants, and discuss mechanisms of cell competition that allow mosaic clones to expand, as well as the...

Thu Apr 11, 2024 22:26
Pleiotropy, epistasis and the genetic architecture of quantitative traits

Nature Reviews Genetics, Published online: 02 April 2024; doi:10.1038/s41576-024-00711-3In this Review, Mackay and Anholt discuss how epistasis and pleiotropy contribute to the genetic architecture of quantitative traits and outline factors that might explain observed differences in their prevalence between model organisms and humans.

Tue Apr 2, 2024 18:50
Genetic variation across and within individuals

Nature Reviews Genetics, Published online: 28 March 2024; doi:10.1038/s41576-024-00709-xIn this Review, the authors compare the characteristics and detection methods of germline and somatic variants. Furthermore, they outline how the interplay between the two types of genetic variation can affect human health.

Thu Mar 28, 2024 17:57

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