Copy-number classifiers for cancer

Nature Reviews Genetics, Published online: 28 June 2022; doi:10.1038/s41576-022-00516-2Two new papers in Nature report copy-number-based classification systems across cancer types that provide routes for personalized therapy.

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Copy-number classifiers for cancer

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Genome-scale single-cell CRISPR screens

Nature Reviews Genetics, Published online: 27 June 2022; doi:10.1038/s41576-022-00517-1A report in Cell takes single-cell CRISPR screens to genome scale and demonstrates how the transcriptional phenotypes can be used to resolve gene functions.

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Genome-scale single-cell CRISPR screens

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Measuring biological age using omics data

Nature Reviews Genetics, Published online: 17 June 2022; doi:10.1038/s41576-022-00511-7Molecular measures of biological ageing based on high-throughput omics technologies are enabling the quantitative characterization of ageing. The authors review how epigenomic, transcriptomic, proteomic, metabolomic and other omics data can be harnessed using machine...

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Measuring biological age using omics data

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Unpacking race and ethnicity in African genomics research

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Unpacking race and ethnicity in African genomics research

Nature Reviews Genetics, Published online: 10 June 2022; doi:10.1038/s41576-022-00506-4In this Comment, the authors highlight caveats about using African ethnicities as population categories in genomics research and emphasize the need for an Africa-oriented humanities research agenda to inform genomics research.

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tRNA dysregulation and disease

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Context-specific Polycomb mechanisms in development

Nature Reviews Genetics, Published online: 09 June 2022; doi:10.1038/s41576-022-00499-0In this Review, Kim and Kingston discuss the compositional and mechanistic diversity of Polycomb repressive complexes (PRCs) and how their context-dependent formation may be required for proper epigenetic regulation in development.

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