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Enhancing regeneration

Nature Reviews Genetics, Published online: 22 September 2020; doi:10.1038/s41576-020-00290-zA study in Science suggests that regeneration-responsive enhancers drive a regeneration response programme (RRP) in killifish and zebrafish and that changes in RRPs might have facilitated the loss of regenerative capacity in vertebrates.

COMPASS and SWI/SNF complexes in development and disease

Nature Reviews Genetics, Published online: 21 September 2020; doi:10.1038/s41576-020-0278-0In this Review, Cenik and Shilatifard focus on two families of Trithorax group proteins: COMPASS histone H3 lysine 4 methyltransferase complexes and SWI/SNF chromatin remodelling complexes. They discuss the roles of these complexes in gene regulation, development...

Exploring the genetic basis of blood cell traits

Nature Reviews Genetics, Published online: 17 September 2020; doi:10.1038/s41576-020-00289-6Two papers in Cell report large-scale genome-wide association studies that provide new insights into the genetic architecture of haematopoietic phenotypes and emphasize the importance of large, diverse data sets.

Exploring the genetic basis of blood cell traits

African ancient DNA research requires robust ethics and permission protocols

Nature Reviews Genetics, Published online: 16 September 2020; doi:10.1038/s41576-020-00285-wIn Africa, there is a disparity in ethics and permission requirements for molecular research on samples from living people versus ancient DNA. At the precipice of the archaeogenomics revolution, heritage agencies require updated policies and procedures for genetic...

African ancient DNA research requires robust ethics and permission protocols

Marking a milestone

Nature Reviews Genetics, Published online: 14 September 2020; doi:10.1038/s41576-020-0280-6As Nature Reviews Genetics turns 20 years, the editors embrace the opportunity to pause and reflect on the past, take stock of the present and look to the future. Please join us in celebrating our Anniversary issue.

Marking a milestone

The evolving metabolic landscape of chromatin biology and epigenetics

Nature Reviews Genetics, Published online: 09 September 2020; doi:10.1038/s41576-020-0270-8Various cellular metabolites provide the chemical moieties for DNA and histone modifications, resulting in a complex interplay between metabolism and epigenetics. In this Review, Dai, Ramesh and Locasale discuss the metabolic regulation of diverse types of chromatin...

The evolving metabolic landscape of chromatin biology and epigenetics

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