From systems to structure — using genetic data to model protein structures

Nature Reviews Genetics, Published online: 10 January 2022; doi:10.1038/s41576-021-00441-wLarge-scale genetic datasets and deep learning approaches are being used to model the structures of proteins or protein complexes. This Review describes approaches based on coevolution, deep mutational scanning and genome-scale genetic or chemical–genetic interaction...

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From systems to structure — using genetic data to model protein structures

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Beyond genetics for cancer evolution

Nature Reviews Genetics, Published online: 05 January 2022; doi:10.1038/s41576-021-00446-5A new study in Nature uses mouse models of acute myeloid leukaemia to demonstrate that non-genetic transcriptional signatures are mitotically heritable determinants of clonal fitness that influence cancer progression.

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Beyond genetics for cancer evolution

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Drug delivery systems for RNA therapeutics

Nature Reviews Genetics, Published online: 04 January 2022; doi:10.1038/s41576-021-00439-4RNA therapies can be used to manipulate gene expression or produce therapeutic proteins. Here, the authors describe the growing number of RNA therapies and their molecular mechanisms of action. They also discuss the path from preclinical drug delivery research...

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Drug delivery systems for RNA therapeutics

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Molecular mechanisms of transgenerational epigenetic inheritance

Nature Reviews Genetics, Published online: 04 January 2022; doi:10.1038/s41576-021-00438-5In this Review, Fitz-James and Cavalli discuss the diverse and often multilayered mechanisms by which transgenerational epigenetic inheritance can occur in different species.

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Engineering synthetic RNA devices for cell control

Nature Reviews Genetics, Published online: 04 January 2022; doi:10.1038/s41576-021-00436-7Synthetic RNA devices integrate sensing, processing and actuation of signals into defined, programmable functions to control cell behaviour. This Review discusses the emerging applications of RNA devices in biomedical research and biomanufacturing, as well as progress...

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Molecular mechanisms of transgenerational epigenetic inheritance

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Engineering synthetic RNA devices for cell control

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