Nature Reviews Genetics, Published online: 18 April 2024; doi:10.1038/s41576-024-00712-2In this Review, the authors summarize our current understanding of nuclear pre-mRNA and mRNA decay pathways. They describe how aberrantly processed mRNAs are targeted for decay in the nucleus and how this process is regulated to finely control gene expression.

Nature Reviews Genetics, Published online: 17 April 2024; doi:10.1038/s41576-024-00723-zIn this Perspective, Werner and colleagues discuss the many potential mechanisms by which natural antisense transcripts (NATs) can regulate expression of their complementary sense transcripts, the biological implications of their regulatory effects and the potential...

Nature Reviews Genetics, Published online: 15 April 2024; doi:10.1038/s41576-024-00732-yIn this Journal Club article, Jenny Tung reflects on a 1975 paper from King and Wilson that emphasized the importance of gene regulatory changes in human evolution.

Nature Reviews Genetics, Published online: 12 April 2024; doi:10.1038/s41576-024-00730-0A paper in Nature Genetics identifies a mechanism involving the transcription factor DUXBL that controls the development of early embryonic mouse cells past stages marked by totipotency.

Nature Reviews Genetics, Published online: 12 April 2024; doi:10.1038/s41576-024-00729-7In this Tools of the Trade article, Dongsheng Bai and Chenxu Zhu describe SIMPLE-seq, a scalable single-cell sequencing method that simultaneously decodes the cytosine modifications 5mC and 5hmC.

Nature Reviews Genetics, Published online: 11 April 2024; doi:10.1038/s41576-024-00715-zGenetic variants acquired early during embryogenesis can affect numerous tissues. The authors review the phenomenon of embryonic mosaicism, with a focus on small variants, and discuss mechanisms of cell competition that allow mosaic clones to expand, as well as the...