Nature Reviews Immunology, Published online: 02 May 2024; doi:10.1038/s41577-024-01029-1An optimal immune response to influenza virus strikes a balance between protective antiviral immune mechanisms and detrimental immunopathology. Here, the authors review the immune mechanisms responsible for each side of this balance and how this may inform future...

Nature Reviews Immunology, Published online: 02 May 2024; doi:10.1038/s41577-024-01030-8Compared with many other vaccines, current vaccines against influenza provide only limited protection. Here, the authors describe the challenges and recent attempts at generating T cell-based vaccines. It may be important to combine T cell-based vaccines with antibody-based...

Nature Reviews Immunology, Published online: 29 April 2024; doi:10.1038/s41577-024-01027-3Here, Rongbin Zhou and colleagues review the different types of damage-associated molecular pattern (DAMP) that trigger sterile inflammation via pattern recognition receptors. The authors group these DAMPs on the basis of whether they arise from inside cells, from...

Nature Reviews Immunology, Published online: 26 April 2024; doi:10.1038/s41577-024-01039-zWei et al. report a role for membrane perforation mediated by gasdermin D pores in disruption of the blood–brain barrier.

Nature Reviews Immunology, Published online: 26 April 2024; doi:10.1038/s41577-024-01038-0A preprint by Yi et al. shows a role for the FAS signalling pathway in controlling the persistence of CAR-modified lymphocytes.

Nature Reviews Immunology, Published online: 24 April 2024; doi:10.1038/s41577-024-01036-2Sex hormones in male mice negatively regulate type 2 innate lymphoid cells in the skin, impairing the induction and activation of dendritic cells and thereby contributing to differences in immunity in males and females.