Defining the functions of PIWI-interacting RNAs

Nature Reviews Molecular Cell Biology, Published online: 22 January 2021; doi:10.1038/s41580-021-00336-yWu and Zamore discuss models of piRNA function and suggest experimental criteria to be followed in order to validate them.

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Defining the functions of PIWI-interacting RNAs

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Programmed and self-organized flow of information during morphogenesis

Nature Reviews Molecular Cell Biology, Published online: 22 January 2021; doi:10.1038/s41580-020-00318-6Tissue morphogenesis is instructed by the interplay of biochemical cues, mechanics and tissue geometry. Conceptually, these instructions can be deployed either deterministically, functioning as a pre-patterned programme for shape changes, or stochastically,...

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Programmed and self-organized flow of information during morphogenesis

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Solutes as controllers of endomembrane dynamics

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Solutes as controllers of endomembrane dynamics

Nature Reviews Molecular Cell Biology, Published online: 21 January 2021; doi:10.1038/s41580-021-00334-0Spencer Freeman draws attention to the role of ion fluxes and vesicular solute composition in regulating dynamics of endomembranes.

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Mapping from sequence to droplets

Nature Reviews Molecular Cell Biology, Published online: 20 January 2021; doi:10.1038/s41580-021-00333-1Alex Holehouse describes the contributions of Nott et al. to the understanding of the mechanisms of liquid–liquid phase separation.

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Mapping from sequence to droplets

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mRNA translation in stress granules is not uncommon

Nature Reviews Molecular Cell Biology, Published online: 18 January 2021; doi:10.1038/s41580-021-00331-3mRNA translation is found to occur in cytosolic stress granules, membraneless organelles that form via liquid−liquid phase separation when cells are exposed to cell-intrinsic or environmental stress.

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mRNA translation in stress granules is not uncommon

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