Voices of the new generation: importance of emotional ‘match’ in mentoring relationships

Nature Reviews Molecular Cell Biology, Published online: 27 January 2023; doi:10.1038/s41580-023-00579-xBased on his personal experience, Alexios-Fotios Mentis urges mentor-seekers to consider emotional ‘match’ and compassion in a future mentor.

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Chilling paternal chloroplasts

Nature Reviews Molecular Cell Biology, Published online: 24 January 2023; doi:10.1038/s41580-023-00582-2Organelles are normally transmitted to progeny exclusively through the maternal germ line. Chung et al. now describe genetic and environmental factors that increase the inheritance of plastids through pollen.

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Younger endogenous retroviruses make us older

Nature Reviews Molecular Cell Biology, Published online: 20 January 2023; doi:10.1038/s41580-023-00580-4The increased expression of certain human endogenous retroviruses induces the cGAS–STING pathway and drives cell senescence and ageing.

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Voices of the new generation: normalizing career choices outside academia

Nature Reviews Molecular Cell Biology, Published online: 19 January 2023; doi:10.1038/s41580-023-00578-yErdinç Sezgin advocates for the need to embrace non-academic career choices.

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Instruction of epigenetic states from DNA sequences

Nature Reviews Molecular Cell Biology, Published online: 16 January 2023; doi:10.1038/s41580-023-00577-zYonatan Stelzer highlights a landmark work from the lab of Howard Cedar that addresses how genome-wide DNA methylation patterns are established and instructed by the DNA sequence.

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Metabolites as signalling molecules

Nature Reviews Molecular Cell Biology, Published online: 12 January 2023; doi:10.1038/s41580-022-00572-wMetabolites are generally viewed as intermediates or products of metabolism. However, many metabolites are also signalling molecules that regulate metabolic reactions and other processes in development, homeostasis and disease. As such, metabolites...

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Nuclear pore complexes as clocks of zygotic genome activation

Nature Reviews Molecular Cell Biology, Published online: 06 January 2023; doi:10.1038/s41580-022-00575-7Early zebrafish embryos increase the size and complexity of their nuclear pore complexes, enabling efficient nuclear import of maternal transcription factors, which induces zygotic genome activation.

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Regulation of axonal regeneration after mammalian spinal cord injury

Nature Reviews Molecular Cell Biology, Published online: 05 January 2023; doi:10.1038/s41580-022-00562-yThe inability of the mammalian central nervous system to functionally regenerate after injury is largely attributable to the limited capacity of injured neurons to regrow axons. In the spinal cord, recent work on the mechanisms restricting axon regrowth...

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A novel G9A–PRC2 complex silences developmental genes in prostate cancer

Nature Reviews Molecular Cell Biology, Published online: 04 January 2023; doi:10.1038/s41580-022-00574-8Fong et al. describe a novel complex that links between H3K9 methylation and H3K27 methylation and has a role in gene silencing and cancer.

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Long non-coding RNAs: definitions, functions, challenges and recommendations

Nature Reviews Molecular Cell Biology, Published online: 03 January 2023; doi:10.1038/s41580-022-00566-8This Consensus Statement addresses the definition, nomenclature and classification of long non-coding RNAs, and provides a shared viewpoint on their features and functions. The authors also discuss research challenges and provide recommendations to...

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