Nature Reviews Molecular Cell Biology, Published online: 05 December 2023; doi:10.1038/s41580-023-00624-9Translation is controlled mainly during its initiation. Recent studies in yeast and mammals provide new insights into the mechanism of translation initiation regulation in health and in various diseases, and open avenues for the development of innovative...

Nature Reviews Molecular Cell Biology, Published online: 24 November 2023; doi:10.1038/s41580-023-00676-xLysosomes orchestrate key cellular functions such as nutrient sensing, degradation of macromolecules and stress adaptation. This Review discusses the integration of signalling pathways at the lysosome and highlights the interaction of lysosomes with...

Nature Reviews Molecular Cell Biology, Published online: 22 November 2023; doi:10.1038/s41580-023-00692-xFlorian Heyd describes a paper that pointed towards alternative splicing as a driver of human cognitive abilities.

Nature Reviews Molecular Cell Biology, Published online: 13 November 2023; doi:10.1038/s41580-023-00673-0Intrinsically disordered regions of proteins lack a defined 3D structure and exist in a collection of interconverting conformations. Recent work is shedding light on how — through their conformational malleability and adaptability — intrinsically...

Nature Reviews Molecular Cell Biology, Published online: 13 November 2023; doi:10.1038/s41580-023-00687-8In this Tools of the Trade article, Manuela Richter (Dumont lab) describes a method to probe mechanisms of cytoskeletal network re-organization that uses a targeted laser to both trigger network remodelling and track network dynamics.

Nature Reviews Molecular Cell Biology, Published online: 07 November 2023; doi:10.1038/s41580-023-00685-wEmily Wong describes a study that provided a quantitative methodology for analyzing ChIP experiments and shifted our understanding of the functionality of transcription factors.