Nature Reviews Molecular Cell Biology, Published online: 22 April 2024; doi:10.1038/s41580-024-00735-xRobert Parton and colleagues discuss novel evidence on the role of dynamin in caveolar endocytosis, which calls into question established models of dynamin-mediated fission.

Nature Reviews Molecular Cell Biology, Published online: 17 April 2024; doi:10.1038/s41580-024-00737-9Reversible S-palmitoylation regulates gasdermin D cleavage, membrane translocation and pore formation to control pyroptosis following bacterial infection.

Nature Reviews Molecular Cell Biology, Published online: 12 April 2024; doi:10.1038/s41580-024-00736-wIn the Journal Club, Fabrizio d’Adda di Fagagna remembers how the work of Judy Campisi changed our understanding of cellular senescence and its effect on physiology and ageing, shaping the future of this research field.

Nature Reviews Molecular Cell Biology, Published online: 12 April 2024; doi:10.1038/s41580-024-00728-wThe first evidence that the formation of protein complexes is linked to protein synthesis was already provided in the early 1960s.

Nature Reviews Molecular Cell Biology, Published online: 10 April 2024; doi:10.1038/s41580-024-00719-xTissues undergo changes in their mechanical and material properties through alterations in cytoskeleton organization, extracellular matrix adhesion and cell–cell connectivity. These mechanical state transitions orchestrate cell proliferation and movement...

Nature Reviews Molecular Cell Biology, Published online: 09 April 2024; doi:10.1038/s41580-024-00734-yThis study presents a new iPS cell-based model to study the mechanisms of tau propagation in 4R tauopathies.