Intracellular mRNA transport and localized translation

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Transcriptional networks controlling stromal cell differentiation

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Intracellular mRNA transport and localized translation

Nature Reviews Molecular Cell Biology, Published online: 09 April 2021; doi:10.1038/s41580-021-00356-8High-resolution imaging technologies have revealed that all living organisms localize mRNAs in subcellular compartments, creating translation hotspots that locally tune gene expression. Insight has been gained into the mechanisms of mRNA transport and...

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Transcriptional networks controlling stromal cell differentiation

Nature Reviews Molecular Cell Biology, Published online: 09 April 2021; doi:10.1038/s41580-021-00357-7Stromal progenitor cells contribute to the maintenance of tissue homeostasis in different organs. In vitro, these mesenchymal stromal cells (MSCs) can differentiate into many cell types. Recent omics and single-cell studies provide insights into the...

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The bacterial social network and beyond

Nature Reviews Molecular Cell Biology, Published online: 08 April 2021; doi:10.1038/s41580-021-00369-3Sunil Laxman highlights the 1987 discovery of cyclic-di-GMP, which prompted scientists to rethink the concept of ‘unicellular’ and the impact of cell signalling.

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A mistranslation-prone transcriptome underlying polyglutamine expansion diseases

Nature Reviews Molecular Cell Biology, Published online: 08 April 2021; doi:10.1038/s41580-021-00368-4Michele Vendruscolo and colleagues propose that polyglutamine repeat expansion diseases could be caused by glutaminyl-tRNA depletion, leading to ribosome frameshifting and mistranslation of transcripts with specific characteristics.

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The bacterial social network and beyond

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A mistranslation-prone transcriptome underlying polyglutamine expansion diseases

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Cytokinin receptor turns 20

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Cytokinin receptor turns 20

Nature Reviews Molecular Cell Biology, Published online: 07 April 2021; doi:10.1038/s41580-021-00365-7Nicolas Papon highlights the work by Kakimoto and colleagues that led to the identification of the cytokinin receptor in plants — 20 years ago.

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