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Big cells, small potential

Nature Reviews Molecular Cell Biology, Published online: 25 November 2021; doi:10.1038/s41580-021-00439-6Lengefeld et al. show that haematopoietic stem cell enlargement explains, at least in part, the reduction of tissue regenerative potential with ageing.

Big cells, small potential

Re-sizing of nuclear pores

Nature Reviews Molecular Cell Biology, Published online: 25 November 2021; doi:10.1038/s41580-021-00437-8Zimmerli and Allegretti et al. show, in fission yeast, that nuclear pores constrict under energy deprivation or osmotic stress, which is linked to a reduction in nuclear membrane tension.

Structures and functions of coronavirus replication–transcription complexes and their relevance for SARS-CoV-2 drug design

Nature Reviews Molecular Cell Biology, Published online: 25 November 2021; doi:10.1038/s41580-021-00432-zSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and other coronaviruses rely on a cohort of specialized viral proteins to transcribe and replicate their RNA genomes. Recent studies have improved our understanding of coronavirus RNA translation,...

Re-sizing of nuclear pores

Structures and functions of coronavirus replication–transcription complexes and their relevance for SARS-CoV-2 drug design

Sleep tight thanks to Parp1

Nature Reviews Molecular Cell Biology, Published online: 25 November 2021; doi:10.1038/s41580-021-00440-zDNA damage accumulation in zebrafish neurons during wakefulness is detected by Parp1, which induces a homeostatic drive to sleep and repair the damage.

Sleep tight thanks to Parp1

Cellular origins of dsRNA, their recognition and consequences

Nature Reviews Molecular Cell Biology, Published online: 23 November 2021; doi:10.1038/s41580-021-00430-1Double-stranded RNAs (dsRNAs) are recognized by designated cellular sensors to mount an immune response. Although dsRNAs are generally of viral origin, dysregulation of several cellular processes can lead to accumulation of endogenous dsRNAs. These...

Cellular origins of dsRNA, their recognition and consequences

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