Quality control of the mitochondrial proteome

Nature Reviews Molecular Cell Biology, Published online: 22 October 2020; doi:10.1038/s41580-020-00300-2The mitochondrial proteome comprises ~1,000–1,500 nuclear-encoded and mitochondrial-encoded proteins. To ensure proper mitochondrial function, cells use multiple mechanisms of quality control that survey mitochondrial protein biogenesis, import and...

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Cell–cell interfaces as specialized compartments directing cell function

Nature Reviews Molecular Cell Biology, Published online: 22 October 2020; doi:10.1038/s41580-020-00298-7Various physiological processes including development and maintenance of epithelia, cell–cell fusion, neuronal function and immune responses rely on the establishment of direct cell–cell contacts. Despite their diversity, the different cell–cell interfaces...

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Quality control of the mitochondrial proteome

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Cell–cell interfaces as specialized compartments directing cell function

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Global view of human protein glycosylation pathways and functions

Nature Reviews Molecular Cell Biology, Published online: 21 October 2020; doi:10.1038/s41580-020-00294-xGlycosylation is the most abundant and diverse form of protein post-translational modification. Recent technical developments are enabling the dissection of the glycome in single cells, providing new insights into its regulation and roles in physiology...

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Global view of human protein glycosylation pathways and functions

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The molecular basis and disease relevance of non-homologous DNA end joining

Nature Reviews Molecular Cell Biology, Published online: 19 October 2020; doi:10.1038/s41580-020-00297-8Non-homologous DNA end joining (NHEJ) is the main repair pathway of DNA double-strand breaks. Recent studies show that synapsis — the crucial pairing of DNA ends — is performed by several mechanisms, and this insight can now be integrated with updates...

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The molecular basis and disease relevance of non-homologous DNA end joining

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Aldolase deployed for surveilling glucose

Nature Reviews Molecular Cell Biology, Published online: 15 October 2020; doi:10.1038/s41580-020-00305-xSheng-Cai Lin discusses discoveries implicating glycolytic enzyme, aldolase, in glucose sensing.

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Aldolase deployed for surveilling glucose

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