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Defining the functions of PIWI-interacting RNAs

Nature Reviews Molecular Cell Biology, Published online: 22 January 2021; doi:10.1038/s41580-021-00336-yWu and Zamore discuss models of piRNA function and suggest experimental criteria to be followed in order to validate them.

Defining the functions of PIWI-interacting RNAs

Programmed and self-organized flow of information during morphogenesis

Nature Reviews Molecular Cell Biology, Published online: 22 January 2021; doi:10.1038/s41580-020-00318-6Tissue morphogenesis is instructed by the interplay of biochemical cues, mechanics and tissue geometry. Conceptually, these instructions can be deployed either deterministically, functioning as a pre-patterned programme for shape changes, or stochastically,...

Programmed and self-organized flow of information during morphogenesis

Solutes as controllers of endomembrane dynamics

Solutes as controllers of endomembrane dynamics

Nature Reviews Molecular Cell Biology, Published online: 21 January 2021; doi:10.1038/s41580-021-00334-0Spencer Freeman draws attention to the role of ion fluxes and vesicular solute composition in regulating dynamics of endomembranes.

Mapping from sequence to droplets

Nature Reviews Molecular Cell Biology, Published online: 20 January 2021; doi:10.1038/s41580-021-00333-1Alex Holehouse describes the contributions of Nott et al. to the understanding of the mechanisms of liquid–liquid phase separation.

Mapping from sequence to droplets

mRNA translation in stress granules is not uncommon

Nature Reviews Molecular Cell Biology, Published online: 18 January 2021; doi:10.1038/s41580-021-00331-3mRNA translation is found to occur in cytosolic stress granules, membraneless organelles that form via liquid−liquid phase separation when cells are exposed to cell-intrinsic or environmental stress.

mRNA translation in stress granules is not uncommon

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