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Architecture of full-length type I modular polyketide synthases revealed by X-ray crystallography, cryo-electron microscopy, and AlphaFold2

Nat. Prod. Rep., 2024, Advance Article DOI: 10.1039/D3NP00060E, Review ArticleSaket R. Bagde, Chu-Young Kim Structures of intact polyketide synthase modules reveal conformational rearrangements and suggest asynchronous use of reaction chambers. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of...

Tue Mar 19, 2024 11:06
Structural, biochemical and bioinformatic analyses of nonribosomal peptide synthetase adenylation domains

Nat. Prod. Rep., 2024, Advance Article DOI: 10.1039/D3NP00064H, Review Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Stephanie C. Heard, Jaclyn M. Winter This review highlights the utility of using adenylation domain structural data, biochemical assays, and computational predictions for prioritizing...

Fri Mar 15, 2024 14:28
Cephalotane diterpenoids: structural diversity, biological activity, biosynthetic proposal, and chemical synthesis

Nat. Prod. Rep., 2024, Advance Article DOI: 10.1039/D3NP00067B, Review ArticleJin-Xin Zhao, Zhan-Peng Ge, Jian-Min Yue This review summarizes a total of 105 cephalotane diterpenoids, covering their isolation, structural features, biological activities, biosynthetic proposals, and completed total synthesis. To cite this article before page numbers are...

Thu Mar 14, 2024 15:21
Bacillus subtilis as a host for natural product discovery and engineering of biosynthetic gene clusters

Nat. Prod. Rep., 2024, Advance Article DOI: 10.1039/D3NP00065F, Review Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Hanne Put, Hans Gerstmans, Hanne Vande Capelle, Maarten Fauvart, Jan Michiels, Joleen Masschelein This review explores the use of Bacillus as a heterologous host...

Mon Mar 11, 2024 14:08
Gold-catalyzed cyclization and cycloaddition in natural product synthesis

Nat. Prod. Rep., 2024, Advance Article DOI: 10.1039/D3NP00056G, Review ArticleBoxu Lin, Tianran Liu, Tuoping Luo This review highlights a curated selection of publications utilizing homogeneous gold-catalyzed cycloaddition and cyclization reactions for the total synthesis of natural products reported from 2016 to mid-2023. To cite this article before...

Fri Mar 8, 2024 13:16
Recent advances in the total synthesis of galantamine, a natural medicine for Alzheimer's disease

Nat. Prod. Rep., 2024, Advance Article DOI: 10.1039/D4NP00001C, Review Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Bichu Cheng, Qi Wang, Yi An, Fener Chen This review discusses the recent synthetic strategies for the total synthesis of galantamine, a natural medicine for the...

Thu Mar 7, 2024 13:31

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