A redox-activatable biopolymer-based micelle for the sequentially enhanced mitochondria-targeted photodynamic therapy and hypoxia-dependent chemotherapy

Chem. Commun., 2020, Accepted ManuscriptDOI: 10.1039/D0CC03667F, CommunicationYanan Li, Linawati Sutrisno, Yanhua Hou, Yang Fei, Chencheng Xue, Yan Hu, Menghuan Li, Zhong LuoA tumor redox-activatable micellar nanoplatform based on the natural-occurring biomacromolecule hyaluronic acid (HA) was developed for the complementary photodynamic/chemotherapy...

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Porous materials as carriers of gasotransmitters towards gas biology and therapeutic applications

Chem. Commun., 2020, Accepted ManuscriptDOI: 10.1039/D0CC03740K, Feature ArticleArnau Carné-Sánchez, Francisco J. Carmona, Chiwon Kim, Shuhei FurukawaThe discovery of NO, CO, and H2S as gasotransmitters and their beneficial role in multiple physiological functions opened an era of research devoted to exogenously deliver them as therapeutic agents....The...

1h

Field-based rational design of p300 histone acetyltransferase inhibitor and systematic evaluation as an anti-fibrotic agent

Chem. Commun., 2020, Accepted ManuscriptDOI: 10.1039/D0CC03553J, CommunicationSoo-Yeon Hwang, Soo-Yeon Park, Jung Yeon Hong, Soo Yeon Lee, Jaeho Shin, Younghwa Na, Myung Hyun Sohn, Ho-Geun Yoon, Youngjoo Kwon(E)-3-(3-(4-((3-Carbamoylbenzyl)oxy)-3-iodo-5-methoxyphenyl) acryloyl)benzamide (A6) was found as a potent p300 inhibitor (IC50 = 870 nM) showing...

2h

Lewis acid–base synergistic catalysis of cationic halogen-bonding-donors with nucleophilic counter anions

Chem. Commun., 2020, Accepted ManuscriptDOI: 10.1039/D0CC04013D, CommunicationKoki Torita, Ryosuke Haraguchi, Yoshitsugu Morita, Satoshi Kemmochi, Teruyuki Komatsu, Shin-ichi FukuzawaCationic halogen-bonding-donors with little or non-coordinating counter anions have attracted great attention as new Lewis acid type organocatalysts. However, these anions...

3h

Progress Toward Colorimetric and Fluorescent Detection of Carbonyl Sulfide

Chem. Commun., 2020, Accepted ManuscriptDOI: 10.1039/D0CC04528D, CommunicationMatthew Cerda, Julia M Fehr, Tobias Sherbow, Michael D PluthWe report here that a fluorescent benzobisimidazolium salt (TBBI) can be used for the fluorescent and colorimetric detection of carbonyl sulfide (COS) over related heterocumulenes including CO2 and CS2 in...The content...

17h

Near perfect head-to-head selectivity on supramolecular photocyclodimerisation of 2-anthracenecarboxylate with self-organised gemini surfactant bilayers

Chem. Commun., 2020, Accepted ManuscriptDOI: 10.1039/D0CC04198J, CommunicationWijak Yospanya, Masaki Nishijima, Yasuyuki Araki, Thierry Buffeteau, Emilie Pouget, Takehiko Wada, Reiko OdaSilicificated self-organised crystalline bilayers of gemini surfactants were used as reaction templates for supramolecular regioselective [4+4] photocyclodimerisation...

17h

Synthesis and [2 + 2]-photodimerisation of monothiomaleimide functionalised linear and brush-like polymers

Chem. Commun., 2020, Accepted ManuscriptDOI: 10.1039/D0CC04067C, CommunicationMohammed Aljuaid , Evelina Liarou, James Steven Town, James Baker, David Haddleton, Paul Wilson[2 + 2]-Photodimerisation of monothiomaleimides has been demonstrated on functionalised linear and brush-like polymers. In water/acetonitrile (95 : 5) mixtures the rate of reaction...

18h

Green light active photocatalyst for complete oxidation of organic molecules

Chem. Commun., 2020, Advance ArticleDOI: 10.1039/D0CC03279D, CommunicationYue Yang, Akira Yamaguchi, Haoyang Jiang, Annabel van der Kooy, Sayuri Okunaka, Mariko Hosogai, Hiromasa Tokudome, Masahiro MiyauchiFe(III) nanoclusters grafted BiVO4 photocatalyst completely decomposes organic molecules into carbon dioxide even under green light.To cite this...

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Synthesis and Hetero-Diels–Alder Reactions of Enantiomerically Pure Dihydro-1H-azepines

Chem. Commun., 2020, Accepted ManuscriptDOI: 10.1039/D0CC04413J, Communication Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Donald Craig, Samuel Richard John Spreadbury, Andrew J P WhiteThermolysis of enantiomerically pure 3-substituted 7,7-dihalo-2-azabicyclo[4.1.0]heptanes in the presence...

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The chemistry of phosphirane-substituted phosphinidene complexes

Chem. Commun., 2020, Accepted ManuscriptDOI: 10.1039/D0CC04501B, CommunicationMin Wang, Tingting Yang, Rongqiang Tian, Donghui Wei, zheng duan, François MatheyThermolysis of 1,1’-biphosphirane pentacarbonylmetal complex offers an access to 3,4-dihydro-1,2-diphosphete and diphosphorus (P2) intermediates. A control reaction proves that this step-wise...

19h