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Editor's Choice: Ovarian response and general ageing?

Many studies demonstrate that earlier menopause is associated with increased risk of cardiovascular disease (CVD): often assumed to be a result of a protracted ageing process. Predictors of earlier menopause include signs of limited ovarian reserve, e.g. low antral follicle count and low anti-Mullerian hormone levels, and have been associated with CVD....

Outcome of in-vitro oocyte maturation in patients with PCOS: does phenotype have an impact?

AbstractSTUDY QUESTIONDoes the phenotype of patients with polycystic ovary syndrome (PCOS) affect clinical outcomes of ART following in-vitro oocyte maturation?SUMMARY ANSWERCumulative live birth rates (CLBRs) after IVM were significantly different between distinct PCOS phenotypes, with the highest CLBR observed in patients with phenotype A/HOP (= hyperandrogenism...

Endosialin defines human stem Leydig cells with regenerative potential

AbstractSTUDY QUESTIONIs endosialin a specific marker of human stem Leydig cells (SLCs) with the ability to differentiate into testosterone-producing Leydig cells (LCs) in vitro and in vivo?SUMMARY ANSWEREndosialin is a specific marker of human SLCs which differentiate into testosterone-producing LCs in vitro and in vivo.WHAT IS KNOWN ALREADYHuman SLCs...

The effect of denudation and injection timing in the reproductive outcomes of ICSI cycles: new insights into the risk of in vitro oocyte ageing

AbstractSTUDY QUESTIONDoes the time elapsed between oocyte pick-up (OPU) and denudation or injection affect the probability of achieving a live birth (LB) in ICSI cycles?SUMMARY ANSWERProlonged oocyte culture before denudation (>4 h) was associated with an increase in clinical pregnancy (CP), LB and cumulative LB (CLB) rates when compared with earlier...

Cumulative live birth rates following blastocyst- versus cleavage-stage embryo transfer in the first complete cycle of IVF: a population-based retrospective cohort study

AbstractSTUDY QUESTIONIs there a difference in the odds of a live birth following blastocyst- versus cleavage-stage embryo transfer in the first complete cycle of IVF?SUMMARY ANSWERAfter adjusting for indication bias, there was not enough evidence to suggest a difference in the odds of live birth following blastocyst- versus cleavage-stage embryo transfer...

Early ovarian ageing: is a low number of oocytes harvested in young women associated with an earlier and increased risk of age-related diseases?

AbstractSTUDY QUESTIONDo young women with early ovarian ageing (EOA), defined as unexplained, and repeatedly few oocytes harvested in ART have an increased risk of age-related events?SUMMARY ANSWERAt follow-up, women with idiopathic EOA had an increased risk of age-related events compared to women with normal ovarian ageing (NOA).WHAT IS KNOWN ALREADYEarly...

Should we still offer elective freezing of all embryos in all IVF cycles?

ABSTRACTElective ‘freeze all’, also called ‘freeze only’, refers to an IVF cycle where all embryos are frozen for later embryo transfer in a non-stimulated cycle, with the promise of increased success rates and prevention of ovarian hyperstimulation syndrome (OHSS) in most patients. However, ‘freeze all’ is associated with significantly higher perinatal...

Loss of anti-Müllerian hormone (AMH) immunoactivity due to a homozygous AMH gene variant rs10417628 in a woman with classical polycystic ovary syndrome (PCOS)

ABSTRACTAnti-Müllerian hormone (AMH) is produced by granulosa cells of pre-antral and small antral ovarian follicles. In polycystic ovary syndrome (PCOS), higher levels of serum AMH are usually encountered due to the ample presence of small antral follicles and a high AMH production per follicular unit which have led to the proposal of AMH as a serum...

An age-based sperm nomogram: the McGill reference guide

AbstractSTUDY QUESTIONHow does age affect various semen parameters?SUMMARY ANSWERFor most semen parameters, the nomogram of the entire population was biphasic, peaking around the fourth decade of life.WHAT IS KNOWN ALREADYIn clinical practice, semen quality is examined by using the WHO 2010 reference limits but these limits do not account for male age....

Fecundability in relation to use of mobile computing apps to track the menstrual cycle

AbstractSTUDY QUESTIONTo what extent does the use of mobile computing apps to track the menstrual cycle and the fertile window influence fecundability among women trying to conceive?SUMMARY ANSWERAfter adjusting for potential confounders, use of any of several different apps was associated with increased fecundability ranging from 12% to 20% per cycle...

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