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Lack of Benefit of Fluvoxamine for COVID-19

The COVID-19 pandemic caught society unprepared. The lack of therapeutic agents for coronaviruses led to a scramble to investigate approved medications for repurposing against SARS-CoV-2. Successes were achieved with immunomodulatory agents for the inflammatory disease processes of COVID-19, but the antiviral search has been less productive. One of...

Viva Las Vagus

I fall for you every time I look at blood, especially when my own gurgles into a test tube or drib-drabs onto the floor, or when my knees lock from standing too long in one place, or even when I eye a needle pointed at me. Once

Health Systems—The Present and the Future

For better or worse, independent medical practices and solo community hospitals are disappearing as they are acquired by hospital-based health systems. In this issue of JAMA, Beaulieu et al provide a detailed review of the current (2018) prevalence and performance of the 580 health systems they identified in the US. They found that 84% of general acute...

Novel Oral Polio Vaccine Safely Induces Antibodies Among Vaccine-Naive Infants

A novel oral poliovirus vaccine type 2 (nOPV2) was well-tolerated among newborns and resulted in nearly all infants developing neutralizing antibodies after 2 doses, a recent trial reported.

Poetry and Medicine and New Poetry Commentaries in JAMA

“I find that I cannot exist without poetry” proclaimed John Keats, the beloved English Romantic poet who many forget was trained as a physician. Keats practiced medicine for only 7 years before abandoning the profession. The medicine of his day, in early 19th-century London, faced dire challenges we might recognize as not unlike those of our times:...


Sequential, Multiple Assignment, Randomized Trial Designs

This JAMA Guide to Statistics and Methods explains sequential, multiple assignment, randomized trial (SMART) study designs, in which some or all participants are randomized at 2 or more decision points depending on the participant’s response to prior treatment.

Clinical Algorithms, Antidiscrimination Laws, and Medical Device Regulation

This Viewpoint discusses recent legal directives by the DHHS and FDA that could increase health care entities’ liability for possible discriminatory biases of clinical algorithms and the need for additional legal clarity to avoid adverse effects on algorithm development and use.

Government Accountability Office Examines Political Interference Among US Health Agencies

Several agencies under the US Department of Health and Human Services (HHS) aren’t adequately shielded against political interference, according to a report by the US Government Accountability Office (GAO).

Estimated Prevalence and Clinical Manifestations of UBA1 Variants Associated With VEXAS Syndrome

This retrospective observational study evaluates UBA1 variants in exome data from individuals in the Geisinger MyCode Community Health Initiative.

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