The COVID-19 pandemic caught society unprepared. The lack of therapeutic agents for coronaviruses led to a scramble to investigate approved medications for repurposing against SARS-CoV-2. Successes were achieved with immunomodulatory agents for the inflammatory disease processes of COVID-19, but the antiviral search has been less productive. One of...
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I fall for you every time I look at blood, especially when my own gurgles into a test tube or drib-drabs onto the floor, or when my knees lock from standing too long in one place, or even when I eye a needle pointed at me. Once
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For better or worse, independent medical practices and solo community hospitals are disappearing as they are acquired by hospital-based health systems. In this issue of JAMA, Beaulieu et al provide a detailed review of the current (2018) prevalence and performance of the 580 health systems they identified in the US. They found that 84% of general acute...
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A novel oral poliovirus vaccine type 2 (nOPV2) was well-tolerated among newborns and resulted in nearly all infants developing neutralizing antibodies after 2 doses, a recent trial reported.
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“I find that I cannot exist without poetry” proclaimed John Keats, the beloved English Romantic poet who many forget was trained as a physician. Keats practiced medicine for only 7 years before abandoning the profession. The medicine of his day, in early 19th-century London, faced dire challenges we might recognize as not unlike those of our times:...
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This JAMA Guide to Statistics and Methods explains sequential, multiple assignment, randomized trial (SMART) study designs, in which some or all participants are randomized at 2 or more decision points depending on the participant’s response to prior treatment.
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This Viewpoint discusses recent legal directives by the DHHS and FDA that could increase health care entities’ liability for possible discriminatory biases of clinical algorithms and the need for additional legal clarity to avoid adverse effects on algorithm development and use.
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Several agencies under the US Department of Health and Human Services (HHS) aren’t adequately shielded against political interference, according to a report by the US Government Accountability Office (GAO).
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This retrospective observational study evaluates UBA1 variants in exome data from individuals in the Geisinger MyCode Community Health Initiative.
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