AbstractBackgroundThe National Institutes of Health (NIH) mobilized more than $4 billion in extramural funding for the COVID-19 pandemic. Assessing the research output from this effort is crucial to understanding how the scientific community leveraged federal funding and responded to this public health crisis.MethodsNIH-funded COVID-19 grants awarded...

To theEditor—We read with great interest the recent update on National Healthcare Safety Network (NHSN) survey data from antimicrobial stewardship programs (ASPs) by O’Leary et al [1]. In particular, we are impressed with the substantial improvement reported by critical access hospitals (CAHs) meeting the 7 Core Elements (19.6% in 2014 vs 88.9% in 2021)...

AbstractBackgroundDalbavancin has been used off-label to treat invasive bacterial infections in vulnerable populations like people who use drugs (PWUD) because of its broad gram-positive coverage and unique pharmacological properties. This retrospective, multisite study examined clinical outcomes at 90 days in PWUD versus non-PWUD after secondary treatment...

AbstractBackgroundThe consequences of low-level viremia in people with HIV are unclear. We used data from the US Military HIV Natural History Study to examine the association of low-level viremia (LLV) and serious non-AIDS events (SNAEs).MethodsIncluded participants initiated antiretroviral therapy after 1996 and had ≥3 viral loads (VLs) measured, using...

AbstractBackgroundThe objective of our study is to describe the clinical presentation, management, and outcome of a large cohort with nontuberculous mycobacteria (NTM) hand infection.MethodsWe reviewed the medical records of all adults (≥18 years) managed at the Mayo Clinic (Rochester, MN) for NTM hand infection between 1998 and 2018.ResultsOur cohort...

AbstractBackgroundA multicountry randomized controlled trial has demonstrated that pan-susceptible pulmonary tuberculosis (TB) can be successfully treated with a 4-month regimen of daily isoniazid, rifapentine, moxifloxacin, and pyrazinamide (HPMZ). We piloted HPMZ in San Francisco (SF) using a modified version of the US Centers for Disease Control...