Wiley Online Library : Advanced Science
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Cutaneous Calcium/Calmodulin‐Dependent Protein Kinase II‐γ–Positive Sympathetic Nerves Secreting Norepinephrine Dictate Psoriasis

Calcium/calmodulin-dependent protein kinase II-γ (CAMK2γ) is activated in imiquimod- or stress-activated sympathetic nerves and increases the interleukin-17 production of dermal γδT cells through the norepinephrine–γδT–adrenoceptor β1–nuclear factor-κB and –p38 axes in the skin, resulting in excessive psoriatic inflammation. Alcaftadine, a small-molecule...

Thu Mar 28, 2024 10:57
A Sustainable Route to Ruthenium Phosphide (RuP)/Ru Heterostructures with Electron‐Shuttling of Interfacial Ru for Efficient Hydrogen Evolution

In the RuP/Ru heterostructure, the electron-deficient Ru atom in the Ru phase is better able to adsorb and dissociate H2O to form H*, whereas the electron-gaining Ru in RuP provides optimized H* adsorption to generate H2. The low H* spillover energy barrier between Ru atoms across the RuP/Ru interface facilitates hydrogen transfer from one side of...

Thu Mar 28, 2024 10:57
UV‐Triggered Hydrogel Coating of the Double Network Polyelectrolytes for Enhanced Endothelialization

In this study, a hydrogel coating of double-network polyelectrolytes on the cover disk of the left atrial appendage occluder is designed. The hydrogel coating binds stably to the occluder and promotes hemocompatibility and endothelial growth on the occluder. The hydrogel coating enhances endothelialization of the occluder in canine vivo, which has...

Thu Mar 28, 2024 10:57
Wemics: A Single‐Base Resolution Methylation Quantification Method for Enhanced Prediction of Epigenetic Regulation

A single-base methylation quantification approach by weighting methylation of consecutive CpG sites (Wemics) in genomic regions. By leveraging the information from neighboring CpG sites, which tend to have correlated methylation patterns, Wemics provides a reliable quantification of DNA methylation levels. Wemics quantification better predicts DNA...

Thu Mar 28, 2024 10:57
Eco‐Friendly and Self‐Sanitizing Microporous Cellulose Sponge (MCS)‐Based Cooling Media for Mitigating Microbial Cross‐Contamination in the Food Cold Chain

This study introduces sustainable, non-melting, self-sanitizing “ice cubes” made from microporous cellulose sponges (MCS) and food-grade photosensitizers, offering a novel solution to enhance cold chain systems. These “ice cubes” match traditional water-based ice in cooling efficiency, withstand multiple freeze-thaw cycles, and effectively reduce...

Thu Mar 28, 2024 10:57
Indium Nitride Nanowires: Low Redox Potential Anodes for Lithium‐Ion Batteries

In this study, robust InN nanowires are introduced on carbon fibers (InN/Au-CFs) as anode for high-performance lithium-ion batteries (LIBs), demonstrating impressive performance with capacities of 416 mAh g–1 at a high rate of 30 A g–1. These results demonstrate the potential of the InN/Au-CFs anode and its suitability for high-rate LIBs. Abstract...

Thu Mar 28, 2024 10:57

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