Wiley Online Library : The Journal of Pathology
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Automated tumor immunophenotyping predicts clinical benefit from anti‐PD‐L1 immunotherapy

Abstract Cancer immunotherapy has transformed the clinical approach to patients with malignancies, as profound benefits can be seen in a subset of patients. To identify this subset, biomarker analyses increasingly focus on phenotypic and functional evaluation of the tumor microenvironment to determine if density, spatial distribution, and cellular...

Tue Mar 26, 2024 10:28
Clonal analysis of metachronous double biliary tract cancers

Abstract The molecular mechanisms underpinning the development of metachronous tumors in the remnant bile duct following surgical resection of primary biliary tract carcinomas (BTCs) are unknown. This study aimed to elucidate these mechanisms by evaluating the clinicopathologic features of BTCs, the alterations to 31 BTC-related genes on targeted sequencing,...

Thu Mar 14, 2024 19:11
Patterns of structural variants within TP53 introns and relocation of the TP53 promoter: a commentary†

Abstract Gene disruption from double-strand DNA breaks within introns is a mechanism of inactivating the tumor suppressor TP53. This occurs more frequently in osteosarcoma and biliary adenocarcinoma compared with other cancer types. The patterns of intron breakpoints within TP53 do not correlate with prevalence, intron length, or overall genome-wide...

Thu Mar 14, 2024 19:11
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Tue Mar 5, 2024 11:55

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