Cancer

Wiley Online Library : Cancer

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Isolated progression of metastatic lung cancer: Clinical outcomes associated with definitive radiotherapy

Background Progressive, metastatic non–small cell lung cancer (NSCLC) often requires the initiation of new systemic therapy. However, in patients with NSCLC that is oligoprogressive (≤3 lesions), local radiotherapy (RT) may allow for the eradication of resistant microclones and, therefore, the continuation of otherwise effective systemic therapy. ...

Long‐term effectiveness of one‐time endoscopic screening for esophageal cancer: A community‐based study in rural China

Background Evidence is required to quantify the population‐level effects of endoscopic screening for esophageal squamous cell carcinoma (ESCC). The objective of this study was to evaluate the long‐term effectiveness of 1‐time endoscopic ESCC screening in a Chinese rural population. Methods This community‐based cohort study was based on an existing...

Neurologic complications of lung cancer

Lung cancer and its associated treatments can cause various neurologic complications, including brain and leptomeningeal metastases, epidural spinal cord compression, cerebrovascular events, and treatment‐related neurotoxicities. Lung cancer care has significantly changed in the last 5 to 10 years, with novel therapies that have affected aspects of...

COVID‐19 outcomes of patients with gynecologic cancer in New York City

Background New York City (NYC) is the epicenter of severe acute respiratory syndrome coronavirus 2 (coronavirus disease 2019 [COVID‐19]) in the United States. Clinical characteristics and outcomes of vulnerable populations, such as those with gynecologic cancer who develop COVID‐19 infections, is limited. Methods Patients from 6 NYC‐area hospital...

Pediatric cancer mortality and survival in the United States, 2001‐2016

Background Although pediatric cancer mortality and survival have improved in the United States over the past 40 years, differences exist by age, race/ethnicity, cancer site, and economic status. To assess progress, this study examined recent mortality and survival data for individuals younger than 20 years. Methods Age‐adjusted death rates were...

Disparities in pediatric and adolescent cancer survival: A need for sustained commitment

Novel HER2‐targeted therapies for HER2‐positive metastatic breast cancer

Human epidermal growth factor receptor 2 (HER2) is overexpressed in approximately 20% of all breast cancers. Before the development of HER2‐directed monoclonal antibodies, HER2‐positive breast cancer was associated with a rather poor prognosis. With the advent of monoclonal HER2‐targeting antibodies (trastuzumab and pertuzumab) and antibody‐drug conjugates...

MASCC/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy

Background Mucositis is a significant toxicity of cancer therapy with numerous systemic sequelae. The goal of this systematic review was to update the Multinational Association of Supportive Care in Cancer and International Society of Oral Oncology (MASCC/ISOO) Clinical Practice Guidelines for the management of mucositis. Methods The literature...

The effect of chemotherapy on survival in patients with nonmetastatic male breast cancer: A population‐based observational study

Background Male breast cancer is a rare malignant disease, accounting for <1% of all breast cancers. The treatment of male breast cancer is mainly extrapolated from the enormous literature and clinical experience in women. The objective of the current study was to assess the relationship between adjuvant chemotherapy and survival in a large population‐based...

Progress in breast cancer research amid the COVID‐19 gloom

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