International Journal of Cancer

Wiley Online Library : International Journal of Cancer

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Conditional relative survival and competing mortality in patients who underwent surgery for lung cancer: a nationwide cohort study

Abstract We aimed to investigate the conditional relative survival (CRS) and competing mortality in patients who underwent surgery for newly diagnosed lung cancer. Using a nationwide population‐based database, we calculated 5‐year CRS on 1 to 5 years survival after surgery. These rates were reported according to age, sex, socioeconomic status, comorbidities,...

First‐line pazopanib in intermediate‐ and poor‐risk patients with metastatic renal cell carcinoma: Final results of the FLIPPER trial

Abstract Temsirolimus has long been the only approved first‐line standard‐of‐care (SOC) with overall survival (OS) benefit in poor‐risk patients with advanced or metastatic renal cell cancer (mRCC). However, tyrosine kinase inhibitors are also commonly used in clinical practice. Pazopanib is a SOC for first‐line mRCC treatment, but for poor‐risk patients...

Poor clinical outcomes and immunoevasive contexture in interleukin‐9 abundant muscle‐invasive bladder cancer

Abstract Chemotherapy and immunotherapy yield survival benefits for muscle‐invasive bladder cancer (MIBC) patients, in which tumor microenvironment has been found to exert crucial roles through tipping the balance between anti‐tumor immunity and immune evasion. This study aims to explore the clinical significance and therapeutic role of intratumoral...

Metabolic perturbations prior to hepatocellular carcinoma diagnosis ‐ Findings from a prospective observational cohort study

Abstract Hepatocellular carcinoma (HCC) development entails changes in liver metabolism. Current knowledge on metabolic perturbations in HCC is derived mostly from case‐control designs, with sparse information from prospective cohorts. Our objective was to apply comprehensive metabolite profiling to detect metabolites whose serum concentrations are...

Impact of the addition of carboplatin to anthracycline‐taxane‐based neoadjuvant chemotherapy on survival in BRCA1/2‐mutated triple‐negative breast cancer

Abstract Whether adding carboplatin to standard neoadjuvant chemotherapy improves survival in BRCA1/2 ‐mutated triple‐negative breast cancer is unknown. In this retrospective study, we aimed to explore the efficacy of anthracycline‐taxane‐ or anthracycline‐taxane/carboplatin‐based neoadjuvant chemotherapy in BRCA1/2 ‐mutated triple‐negative breast...

Chronic lymphocytic leukemia patients with IGH translocations are characterized by a distinct genetic landscape with prognostic implications

ABSTRACT Chromosome 14q32 rearrangements/translocations involving the immunoglobulin heavy chain (IGH ) are rarely detected in chronic lymphocytic leukemia (CLL). The prognostic significance of the IGH translocation is controversial and its mutational profile remains unknown. Here, we present for the first time a comprehensive next‐generation sequencing...

Choosing the optimal HPV vaccine: The health impact and economic value of the nonavalent and bivalent HPV vaccines in 48 Gavi‐eligible countries

ABSTRACT The human papillomavirus (HPV) vaccines may provide some level of cross‐protection against high‐risk HPV genotypes not directly targeted by the vaccines. We evaluated the long‐term health and economic impacts of routine HPV vaccination using either the nonavalent HPV vaccine or the bivalent HPV vaccine in the context of 48 Gavi‐eligible countries....

Estimated global cancer incidence in the oldest adults in 2018 and projections to 2050

Abstract Using GLOBOCAN estimates, we describe the estimated cancer incidence among adults aged 80 years or older at the regional and global level in 2018, reporting the number of new cancer cases, and the truncated age‐standardised incidence rates (per 100,000) for all cancer sites combined for this age group. We also presented the five most frequent...

Analysis in the Prospective Lynch Syndrome Database identifies sarcoma as part of the Lynch Syndrome tumor spectrum

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