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Wiley Online Library : Glia

Latest articles

Carbon monoxide controls microglial erythrophagocytosis by regulating CD36 surface expression to reduce the severity of hemorrhagic injury

Main points Carbon monoxide produced by heme oxygenase controls microglial erythrophagocytosis via a pathway involving CD36 surface‐expression. CD36‐deficiency leads to aggravated neuronal injury following experimental subarachnoid hemorrhage in mice. Abstract Microglial erythrophagocytosis is crucial in injury response to hemorrhagic...

Radial glia in the zebrafish brain: Functional, structural, and physiological comparison with the mammalian glia

Main Points Beyond its neurogenic ability, zebrafish radial glia play homeostatic roles at the level of neural circuits and brain barriers. Thus, the zebrafish radial glia can be considered as the ancestral homolog of mammalian radial and astroglia combined. Abstract The neuroscience community has witnessed a tremendous expansion of glia research....

Morphological and molecular alterations of reactive astrocytes without proliferation in cerebral cortex of an APP/PS1 transgenic mouse model and Alzheimer's patients

Morphological and molecular alterations of reactive astrocytes are characterized in cerebral cortex of an Alzheimer's disease (AD) mouse model and Alzheimer's patients. Cortical reactive astrocytes in APP/PS1 mice and AD patients do not undergo proliferation. Abstract Astrocytes are fundamental for maintaining brain homeostasis and are commonly...

Regulatory function of microRNAs in microglia

Abstract Microglia are CNS‐resident cells involved in immune surveillance and maintenance of intercellular homeostasis, while also contributing to neurologic pathologies. MicroRNAs (miRNAs) are a class of small (~22 nucleotides) single‐stranded noncoding RNAs that participate in gene regulation at the post‐transcriptional level. miRNAs typically...

Activation of astrocytic sigma‐1 receptor exerts antidepressant‐like effect via facilitating CD38‐driven mitochondria transfer

Main Points Astrocyte is a direct cellular target of Sig‐1R producing antidepressant‐like effect. Activation of astrocytic Sig‐1R is sufficient to exert antidepressant‐like effect. Activation of Sig‐1R promotes astrocyte mitochondria transfer. Abstract Despite sigma‐1 receptor (Sig‐1R) is a promising therapeutic target in depression,...

Chromatin remodelers in oligodendroglia

Main Points Chromatin remodelers (CRs) regulate each stage of oligodendrogenesis CRs cooperate with key transcription factors to regulate (re)myelination CRs have distinct and overlapping functions depending on regions, processes, and gene‐networks. Abstract Oligodendrocytes, the myelinating cells in the vertebrate central nervous system,...

Microglia influence host defense, disease, and repair following murine coronavirus infection of the central nervous system

Depletion of microglia impairs T cell control of murine coronavirus replication and increases neurologic disease. Abstract The present study examines functional contributions of microglia in host defense, demyelination, and remyelination following infection of susceptible mice with a neurotropic coronavirus. Treatment with PLX5622, an inhibitor...

Disruption of dystonin in Schwann cells results in late‐onset neuropathy and sensory ataxia

Abstract Dystonin (Dst ) is a causative gene for Dystonia musculorum (dt ) mice, which is an inherited disorder exhibiting dystonia‐like movement and ataxia with sensory degeneration. Dst is expressed in a variety of tissues, including the central nervous system and the peripheral nervous system (PNS), muscles, and skin. However, the Dst ‐expressing...


Neuroglial transmitophagy and Parkinson's disease

Damaged mitochondria of degenerating dopaminergic synapsis are transferred to striatal astrocytes for their degradation (transmitophagy). A transmitophagy failure could be critical in Parkinson's disease. Abstract Mitophagy is essential for the health of dopaminergic neurons because mitochondrial damage is a keystone of Parkinson's disease. The...

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