Main Points Modification of Aβ (Aβ3(pE)-42) impairs astrocytic clearance Aβ3(pE)-42 accumulates within the astrocytic lysosomes disrupting their function Aberrant lysosomal function links to astrocytic inflammatory response and synapse loss Abstract The disruption of astrocytic catabolic processes contributes to the impairment of amyloid-β...

Main Points Phf8 promotes oligodendroglial proliferation. Phf8 impairs oligodendrocyte differentiation. Olig2 is a direct target and major effector of Phf8 in oligodendroglia. Abstract The plant homeodomain finger protein Phf8 is a histone demethylase implicated by mutation in mice and humans in neural crest defects and neurodevelopmental...

Glia, Volume 72, Issue 6, Page 1013-1015, June 2024.

Cover Illustration: Immunofluorescence staining of iPSC-derived glial progenitors. Astrocytes (in green) are stained with GFAP, the nuclei of oligodendrocyte precursors (OPCs, in red) are stained with OLIG2. Nuclei are stained in blue with Hoechst 33342. (See Piscopo, V., et al, https://doi.org/10.1002/glia.24524)

Main Points Systemic challenge with low dose LPS increases microglial proliferation without causing overt inflammation. Repeated challenges with low dose LPS during healthy life accelerate the onset of amyloidosis and increase Dectin-1+ cells in AD-like pathology. Abstract Several in vivo studies have shown that systemic inflammation, mimicked...

Main Points Pexidartinib prevents neuropathic pain in normal male but not in female and gonadectomized male mice. There are sex- and androgen-dependent differences in spinal microglia and dorsal root ganglia macrophages but not in sciatic nerve macrophages. Abstract It is well-established that spinal microglia and peripheral macrophages...