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Lewis‐Acid‐Catalyzed (3+2)‐Cycloadditions of Donor‐Acceptor Cyclopropanes with Thioketenes

The reactivity of donor-acceptor (D-A) cyclopropanes towards thioketenes was investigated. In a (3+2)-cycloaddition using Sc(OTf) 3 as Lewis acidic catalyst, the corresponding exocyclic thioenol ethers were formed in moderate to good yields. Unsymmetrical thioketenes provided E/Z mixtures at the double bond, with the Z isomer being preferred.

Efficient Synthesis of tert‐Butyl 2,4‐Dialkynylated and 2‐Alkynylated‐4‐arylated‐1H‐imidazole‐1‐carboxylate via Regioselective Sonogashira Cross‐coupling Reaction

An efficient regioselective cross-coupling reactions of tert -butyl 2,4-dibrominated-5-methyl-1 H -imidazole-1-carboxylate is reported under simple and mild conditions. This new synthetic route selectively gave an easy access to 2,4-dialkynylated and 2-alkynylated-4-arylated-1 H -imidazole-1-carboxylate in good to excellent yields.

Facile N‐Formylation of Amines on Magnetic Fe3O4–CuO Nanocomposites

A facile, eco-friendly, efficient, and recyclable heterogeneous catalyst is synthesized by immobilizing copper impregnated on mesoporous magnetic nanoparticles. The surface chemistry analysis of Fe 3 O 4 –CuO nanocomposites (NCs) by XRD and XPS demonstrates the synergistic effect between Fe 3 O 4 and CuO nanoparticles, providing mass-transfer...

Haloacetylated Enol Ethers: a Way Out for the Regioselective Synthesis of Biologically Active Heterocycles

Haloacetylated enol ethers are suitable starting materials for the regioselective synthesis of biologically relevant heterocyclic scaffolds. With this in mind, this review brings together advances in both synthetic and biological/pharmacological activities. Abstract This review describes advances in the synthesis of heterocyclic scaffolds (associated...

Highly efficient heterogeneous V2O5@TiO2 catalyzed the rapid transformation of boronic acids to phenols

The hydroxylation of boronic acid into phenol using heterogeneous V2O5@TiO2 catalystis described. The methodology was successfully applied to transform a varied range of (hetero)aryl, pharmaceutical-derived and natural product-derived boronic acid into their corresponding phenols in good to excellent yields. Abstract A V2O5@TiO2 catalyzed green...

KO‐t‐Bu Catalyzed Thiolation of β‐(Hetero)arylethyl Ethers via MeOH Elimination/hydrothiolation

We describe a KO-t-Bu catalyzed thiolation of β-(hetero)arylethyl ethers through MeOH elimination to form (hetero)arylalkenes followed by anti-Markovnikov hydrothiolation to afford linear thioethers. The system works well with a variety of β-(hetero)arylethyl ethers, including electron-deficient, electron-neutral, electron-rich, and branched substrates...

Influence of N‐Substitution in 3‐Alkyl‐3‐hydroxyisoindolin‐1‐ones on the Stereoselectivity of Brønsted Acid‐Catalyzed Synthesis of 3‐Methyleneisoindolin‐1‐ones

Brønsted acid-catalyzed dehydration of 3-alkyl-3-hydroxyisoindolin-1-ones is discussed. The reaction is efficiently catalyzed by methanesulfonic acid in acetonitrile and provides the corresponding 3-methyleneisoindolin-1-ones. The E/Z stereochemistry around the exocyclic double bond is in strong correlation with the size of the N-substituent. Selective...

25‐Propyloxy‐26,27‐dibenzoyloxy‐calix[4]as Precursor for the Synthesis of Inherently Chiral Calixarenes

25-Propyloxy-26,27-dibenzoyloxy-calix[4]is a convenient precursor for the formation of inherently chiral configuration on the calixarene platform. The synthesis of inherently chiral calixarenes with one, two and three different functional groups on the upper rim was described. Abstract This paper shows that 25-propyloxy-26,27-dibenzoyloxy-calix[4]arene...

Synthesis of 10H‐indolo[1,2‐a]indole Derivatives via Intramolecular Cycloaddition and H‐Migration

A novel method for synthesizing 10H-indolo[1,2-a]indole derivatives has been devised. All the products are capable to be prepared by applying the intramolecular cyclization strategy at room temperature. The reaction was realized through I2/ZnI2 catalyzed intramolecular nucleophilic addition, hydrogen migration, and rearrangement procedures. The electrical...

Base‐catalyzed Hydrosilylation of Nitriles to Amines

Base-catalyzed hydrosilylation of nitriles to amines is and esters to silylated alcohols is reported. This protocol tolerates electron-rich and electron-neutral olefins and works in the presence of basic functional groups (e.g. tertiary amines) but fails for acidic substrates, such as phenols and NH anilines. This catalytic system does not tolerate...

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