Dual reactivity of key intermediates β-fluorocarbanions leads to hydroamination versus defluoroamination in reactions between α-(trifluoromethyl)styrenes and 2-pyridones. The competition between defluorination and protonation is mainly influenced by the sources of protons. Consequently, the pK aH values may serve as reliable indicators for predicting...

An efficient method has been developed to achieve for addition-ring opening cascade reaction, according a series of aza-bicyclic maleimide derivatives with good yields and diastereoselectivities. Abstract An efficient method has been developed to facilitate the addition-ring opening cascade reaction of vinylogous oxindole, resulting in the...

An efficient SN2-oxidation cascade reaction for synthesizing heteroaryl 2-sulfonamides from disulfanes and amines is described. The methodology has broad scope, affording heteroaryl 2-sulfonamides in moderate to good yields, and was applied to the synthesis of H3B-968, a potential Werner Syndrome Protein (WRN) small molecule inhibitor. Abstract...

We report an unprecedented Ni-catalyzed direct monofluoromethylthiolation of acyl chlorides, in situ generated from carboxylic acids, with elemental sulfur (S8) as the S source and fluoroiodomethane (ICH2F) as the CH2F radical source to produce a series of monofluoromethylthioesters in moderate to good yields. This approach features excellent functional...

Two cis-connected cyclic tetraphenylethylenes, [2]c-CTPE and [3]c-CTPE, were synthesized by platinum-mediated cyclization. The strain energy of [2]c-CTPE is up to 86.28 kJ ⋅ mol−1. [2]c-CTPE and [3]c-CTPE demonstrates typical Aggregation-Induced Emission (AIE) characteristics. Moreover, both [2]c-CTPE and [3]c-CTPE display mechanofluorochromic properties....

A synthesis of amides from aldehydes promoted by the photoactive complex of Fe2SO4 with 2-picolinic acid, NaCl as chlorine source, Na2S2O8 as a benign oxidant is reported. The reaction is mediated by visible-light and is carried out at room temperature in absence of additives. Fe2SO4 is a readily available earth-abundant metal (EAMs) salt, not needed...