Wiley Online Library : European Journal of Organic Chemistry
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Access to Saturated Aza‐Heterocycles using the Borrowing Hydrogen Methodology

This concept article highlights the metal-catalyzed Borrowing Hydrogen (BH) annulation strategy for the preparation of saturated aza-heterocycles from diols and triols. Special attention will also be devoted to stereocontrol issues for the preparation of chiral N-heterocycles. Abstract Borrowing hydrogen (BH) has reached a wide attention from...

Wed Feb 28, 2024 11:56
PTSA‐Catalyzed [3+2] Cycloaddition of in Situ Generated 3‐Ylidene Oxindoles with Coumarin‐Based N‐Phenyl Enamine Derivatives

Oxindole-bearing pyrrolocoumarin frameworks were synthesized from 3-ylidene oxindoles that were generated in situ and coumarin-based N-phenyl enamines. The products were isolated in high yields by simple filtration. The results from variable-temperature NMR studies and DFT calculations supported the observed formation of rotamers. Abstract Brønsted...

Wed Feb 28, 2024 11:56
Progress in the Synthesis of Cyclobutenones

This review provides a comprehensive summary of the synthetic strategies employed for cyclobutenone synthesis, encompassing the literature from the last few decades. The features and advantages of these strategies are systematically outlined, offering a clear understanding of their respective strengths and benefits. Abstract In recent years,...

Wed Feb 28, 2024 11:56
Pd‐Catalyzed Synthesis of Aryl Esters Involving Difluorocarbene Transfer Carbonylation

An effective approach of Pd-catalyzed aryl halides, phenols to access of aryl esters is developed by difluorocarbene as a carbonyl source. This enables the three-component reaction to be formed directly one C−O, one C=O and one C−C bonds in a one-pot, one-step reaction, without extra separating and purifying the intermediate product. Abstract...

Wed Feb 28, 2024 11:56
Library Synthesis of Cyclobutanol Derivatives by Hyperbaric [2+2] Cycloaddition Reactions

Cyclobutanes have garnered increased attention in medicinal chemistry because of their distinctive puckered structure, sp3 richness, and rigidity, offering potential advantages in pharmacological properties. In this study a two-diversification-point library of 3-amino-3-[(arenesulfonyl)methyl]cyclobutanols was synthesized through a hyperbaric [2+2]...

Wed Feb 28, 2024 11:56
Kinetic Resolution of a Planar‐Chiral [2.2]Paracyclophane via Michael Addition to Nitroolefins Catalyzed by N‐Terminal Guanidinylated Helical Peptide

Kinetic resolution of 4-(2-nitrovinyl)[2.2]paracyclophane based on N-terminal-guanidinylated resin-bound helical peptide catalyzed asymmetric Michael addition of malonate esters was developed. This approach provides a new pathway to enantiopure paracyclophane derivatives characterized by both planar and central chirality, along with the recovery of...

Wed Feb 28, 2024 11:56

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