The atavism theory proposes that cancer results from the re-expression of normally repressed genes forming a program inherited from unicellular ancestors. This family of hypotheses was proposed by several authors and has changed overtime. We point important issues in this theoretical framework and highlight a requirement for clarification and unification....
Methionine restriction (MR) has health benefits, but its mechanisms remain incompletely understood. We propose a mechanism termed mitoSAMR, wherein lipoylation plays a crucial role in the mitochondrial response to S-adenosylmethionine depletion caused by MR. The constraint of lipoylation redirects acetyl-CoA from energy metabolism towards the nitrogenic...
Astrocytic [Cl-]i is high during sleep and low during wakefulness. It depends on glutamate and GABA mediated anion conductance and on the connexin connected syncytium. We here discuss how these factors affect brain state formation, relate to sleep disturbances and how sleep-inducing pharmacology affects astrocytic Cl- homeostasis. Abstract...
The autophagy initiation complex formation is crucial and involves stepwise assembly. TOR/mTOR and Snf1/AMPK regulate this process by phosphorylating autophagy-related proteins. Atg1/ULK1 and Ypt1/Rab1 are also vital. Additional molecules like histone acetyltransferase (HAT) and lactic acid are involved. We discuss the molecular regulation mechanisms...
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