Enzymatic Late‐Stage Modifications: Better Late than Never

Enzyme catalysis is gaining increasing importance in synthetic chemistry. Nowadays, the growing number of biocatalysts accessible by means of bioinformatics and enzyme engineering opens up an immense variety of reactions that can be performed selectively under mild conditions. Biocatalysis especially provides excellent opportunities for late‐stage modification...

16h

Enhanced light‐driven hydrogen production by self‐photosensitized biohybrid systems

Storage of solar energy as hydrogen provides a platform towards decarbonizing our economy. One emerging strategy for solar fuels production is to use photocatalytic biohybrid systems combining the high catalytic activity of non‐photosynthetic microorganisms with the high light‐harvesting efficiency of metal semiconductor nanoparticles. However, few...

1d

Cys‐Cys and Cys‐Lys Stapling of Unprotected Peptides Enabled by Hypervalent Iodine Reagents

Easy access to a wide range of structurally diverse stapled peptides is crucial for the development of inhibitors of protein‐protein interactions. Herein, we report bis‐functional hypervalent iodine reagents for two‐component cysteine‐cysteine and cysteine‐lysine stapling yielding structurally diverse thioalkyne linkers. This stapling method works with...

1d

Heterometallic Actinide‐Containing Photoresponsive Metal‐Organic Frameworks: Dynamic and Static Tuning of Electronic Properties

Acquiring fundamental knowledge of properties of actinide‐based materials is a necessary step to create new possibilities for addressing the current challenges in the nuclear energy and nuclear waste sectors. In this report, we established a photophysics‐electronics correlation for actinide‐containing metal‐organic frameworks (An‐MOFs) as a function...

1d

Bright and Robust Phosphorescence Achieved via Non‐Covalent Clipping

Phosphorescent compounds with high emission intensities are important for their practical applications, which require to lower the susceptibility of triplet excitons to surroundings. Herein a non‐covalent clipping strategy has been developed to attain this objective, by designing a tweezer receptor to encapsulate Pt(II)‐based triplet emitters via two‐fold...

1d

Metal–Free Directed C–H Borylation of Pyrroles

Robust strategies to enable the rapid construction of complex organoboronates in selective, practical, low‐cost, and environmentally friendly modes remain conspicuously underdeveloped. Here, we develop a general strategy for the site‐selective C–H borylation of pyrroles by using only BBr 3  directed by pivaloyl groups, avoiding the use of any metal....

1d

Cryo‐EM resolves molecular recognition of an optojasp photoswitch bound to actin filaments in both switch states

Actin is essential for key processes in all eukaryotic cells. Cellpermeable  optojasps  provide  spatiotemporal control of the actin cytoskeleton, confining toxicity and potentially rendering F‐actin druggable by photopharmacology. Here, we report cryo electron microscopy (cryo‐EM) structures of both isomeric states of one  optojasp  bound to actin...

1d

Hybrid wireframe DNA nanostructures with scaffolded and scaffold‐free modules

Scaffolded DNA origami approach and scaffold‐free LEGO approach both demonstrate extraordinary self‐assembly capability for the construction of all kinds of complex DNA nanostructures. Combining the construction elements of the two approaches, we introduce a hybrid framework to build wireframe structures in this study. A collection of two‐dimensional...

1d

The Total Synthesis of Chondrochloren A

The first total synthesis of chondrochloren A is accomplished using a 1,2‐metallate rearrangement addition as an alternative for the Nozaki‐Hiyama‐Kishi reaction. This transformation also avoids the inherent challenges of this polyketide segment and provides a new, unprecedented strategy to assemble polyketidal frameworks. The formation of the Z‐enamide...

1d

Visible‐light‐induced Intramolecular Double Dearomative Cycloaddition of Arenes

Herein we report visible‐light‐induced intramolecular double dearomative cycloaddition of arenes. Compared with the well‐known photodimerization of arenes under ultraviolet irradiation, the current reactions are carried out under mild conditions and feature wide substrate scope. A large array of structurally‐diverse polycyclic indoline derivatives is...

2d