Chemistry - A European Journal

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Meticulous Doxorubicin Release from pH‐Responsive Nanoparticles Entrapped within an Injectable Thermoresponsive Depot

The acid‐mediated, temperature‐controlled release of doxorubicin from poly(amino acid) particles embedded within a gel depot is reported. The particles are stable within aqueous solution, and able to withhold an anti‐cancer therapeutic for prolonged periods in solution of physiological pH. This injectable system enables localised and controlled chemotherapeutic...

Light Runs Across Iron Catalysts in Organic Transformations

Light runs across iron catalysts: This Concept summarizes the recent advances in iron/photoredox dual catalysis, photoactive iron catalysts in photochemistry, as well as light‐induced generation of active iron catalysts in organic transformations. Prospects for the future of the field are also discussed. Abstract Over the past decades, organometallic...

Incorporation of Boron into Uranium Metallacycles: Synthesis, Structure, and Reactivity of Boron‐Containing Uranacycles Derived from Bis(alkynyl)boranes

U‐B‐Ring: The first bis(alkynyl)borane‐supported actinide complexes are reported. Depending on the B‐substituent, the bis(alkynyl)borane ligand can either coordinate in an η 5‐manner or undergo a UIV‐assisted intramolecular [2+2] cycloaddition to give a highly unusual fused bicyclic structure. Abstract The reaction of uranacyclopropene complex...

Evaluation of Pd→B Interactions in Diphosphinoborane Complexes and Impact on Inner‐Sphere Reductive Elimination

Ligand effects: The borane acceptor in diphosphinoborane ligands discriminates between the oxidation state PdII and Pd0, stabilizing the latter. The impact of the Pd→B interaction on inner‐sphere C−N bond reductive elimination of N,N‐dimethyl‐4‐nitroaniline was investigated (see scheme). Abstract The dative Pd→B interaction in a series of RDPBR’...

Diversely Functionalised Cytochalasins Through Mutasynthesis and Semi‐Synthesis

A U2OS‐cell triple‐stained for the actin cytoskeleton with a fluorescently‐tagged cytochalasin‐derivative (red) and phalloidin (green) as well as the nucleus (blue) is depicted in the cover image. Cytochalasins are potent ligands of the barbed ends of actin filaments. Here, mutasynthesis was used to create halogenated and azido‐cytochalasins which were...

Zinc Interactions with a Soluble Mutated Rat Amylin to Mimic Whole Human Amylin: An Experimental and Simulation Approach to Understand Stoichiometry, Speciation and Coordination of the Metal Complexes

Stoichiometry, speciation and coordination features of zinc(II) complexes with islet amyloid polypeptide (IAPPS) were unveiled by a combined ESI‐MS, potentiometric and NMR study. Mononuclear species start to form around pH 6; Zn2+ binds both His18 and N‐amino terminus in rat‐IAPP(1‐37; R18 H). NMR and DFT findings confirm the binding and stress the...

Carbon Monoxide Coupling Reactions: A New Concept for the Formation of Hexahydroxybenzene

A very old reaction in a new light: A very old reaction is the formation of the hexapotassium salt of hexahydroxybenzene C6(OK)6 by the interaction of metallic K and CO. To date, only speculations exist about the reaction pathway for its formation. A novel concept is presented, based on metalla‐dioxo‐cyclobutadiynes (cis‐2,5‐dioxo‐butatriene as formal...

Controlling Regioselectivity in Palladium‐Catalyzed C−H Activation/Aryl–Aryl Coupling of 4‐Phenylamino[2.2]paracyclophane

C−H First: Palladium‐catalyzed preferential and exclusively para‐ site‐selective C−H activation/aryl–aryl bond formation with a preference over N‐arylation under the Buchwald–Hartwig amination reaction conditions of 4‐N‐phenylamino[2.2]paracyclophane is developed. This unanticipated reactivity/selectivity is investigated in terms of generality, compatibility,...

Controlling Regioselectivity in Palladium‐Catalyzed C−H Activation/Aryl–Aryl Coupling of 4‐Phenylamino[2.2]paracyclophane

C−H activation is targeted in the cover image. This work reports the palladium‐catalyzed preferential and exclusively para‐ site‐selective C−H activation/aryl–aryl bond formation with a preference over N‐arylation under Buchwald–Hartwig amination reaction conditions of 4‐N‐phenylamino[2.2]paracyclophane. The cover was created by the author team at IOC....

Semihydrogenation of Alkynes Catalyzed by a Pyridone Borane Complex: Frustrated Lewis Pair Reactivity and Boron–Ligand Cooperation in Concert

A case of important cooperation: The semihydrogenation of alkynes catalyzed by a pyridonate borane complex is reported. While the catalyst can be described as an intramolecular frustrated Lewis pair, it is the change in the coordination mode of the pyridonate substituent upon H2 bond activation that enables dissociation of the formed pyridone borane...

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