Cross‐Talks Between Sulfane Sulfur and Thiol at a Zinc(II) Site

A tripodal [ZnII] complex has been demonstrated to assist cross-talks between sulfane sulfur and thiol under ambient base-free conditions, thereby revealing new possible roles of [ZnII] coordination motifs in thiol persulfidation, polysulfide formation, and its cross-over with free thiol relevant to sulfur biochemistry. Abstract Transformations...

18h

A Porous Sulfonated 2D Zirconium Metal–Organic Framework as a Robust Platform for Proton Conduction

2D Zr-MOF gets sulfonated: By using the strategy of pre-assembly chlorosulfonation applied to a linker precursor, the first sulfonated zirconium-based metal–organic framework (MOF) with two-dimensional (2D) structure is synthesized. The highly stable porous platform is proton conductive under humidified and anhydrous conditions. The 2D nature of the...

18h

Selective Labeling of Peptides with o‐Carboranes via Manganese(I)‐Catalyzed C−H Activation

The direct incorporation of a carborane moiety into tryptophan-containing peptides is presented as a sustainable method to access novel potential anti-cancer and BNCT agents via non-toxic manganese(I) catalysis. Abstract A robust method for the selective labeling of peptides via manganese(I) catalysis was devised to achieve the C-2 alkenylation...

18h

Photochemical Deracemization of a Medicinally‐Relevant Benzopyran using an Oscillatory Flow Reactor

Photo-transformation: Unlike classical enantiomeric resolution methods, crystallization-induced diastereomer transformations (CIDTs) allow full conversion to the desired enantiomer. Using photochemical racemization for a CIDT has not before been published in the scientific literature. We report the use of an oscillatory flow reactor for efficient irradiation,...

2d

Catalytic Asymmetric Syntheses of Alkylidenecyclopropanes from Allenoates with Donor‐acceptor and Diacceptor Diazo Reagents

The first diastereo- and enantioselective cyclopropanation reactions of electron-deficient allenes with donor-acceptor and diacceptor diazo reagents are described. The desired enantioenriched alkylidenecyclopropanes (ACPs) were obtained in high yields with high diastereo- and enantioselectivities in the presence of Rh 2 (( S )-TCPTAD) 4 or Rh...

2d

Single‐Molecule Sensing of Acidic Catecholamine Metabolites Using a Programmable Nanopore

Acidic catecholamine metabolites, which could serve as diagnostic markers for many diseases, demonstrate an importance of accurate sensing. However, they share a highly similar chemical structure, which is a challenge in the design of sensing strategies. A nanopore may be engineered to sense these metabolites in a single molecule manner. To achieve...

2d

GNPS‐Guided Discovery of Madurastatin Siderophores from the Termite‐Associated Actinomadura sp. RB99**

Metabolomic analysis of cocultures of Actinomadura sp. RB99 with fungal symbionts of termites allowed for the MS-guided isolation of four unreported madurastatin derivatives, including a siderophore-metal complex thereof. Abstract In this study, we analyzed if Actinomadura sp. RB99 produces siderophores that that could be responsible for the antimicrobial...

4d

Radical Reactivity of the Biradical [⋅P(μ‐NTer)2P⋅] and Isolation of a Persistent Phosphorus‐Cantered Monoradical [⋅P(μ‐NTer)2P‐Et]

Revealing a radical route: The radical reactivity of the biradical [⋅P(μ-NTer)2P⋅] has been investigated. It was possible to synthesize the persistent phosphorus-centered monoradical [⋅P(μ-NTer)2P−Et] and identify it as a radical intermediate during the addition of bromoethane to [⋅P(μ-NTer)2P⋅]. A possible stepwise mechanism of this reaction was formulated...

4d

Identifying the Molecular Origins of Green BN‐TADF Material Degradation and Device Stability via in situ Raman Spectroscopy

Terminal substituents and conformational changes have a great impact on OLED device efficiency and stability investigated by in situ Raman spectroscopy. Compared to BN-PhOH with the lowest EQEmax of 19.0 % and LT50 of 1.7 h, BN-PhN(CH3)2 exhibited the longest OLED device lifetime (7.7 h), enhanced EQEmax of 24.1 %, and alleviated efficiency roll-off,...

4d

Indole Editing Enabled by HFIP‐Mediated Ring‐Switch Reactions of 3‐Amino‐2‐Hydroxyindolines

Indole multi-site editing!! Unprecedented indole multi-site editing was accomplished by a unique ring-switch reaction of hemiaminals. Abstract This work reports the novel reactivity of hemiaminal as a precursor for indole editing at the multi-site. The HFIP-promoted indole editing of indoline hemiaminals affords 2-arylindoles through a ring-switch...

4d