Enzymatic Late‐Stage Modifications: Better Late than Never

Enzyme catalysis is gaining increasing importance in synthetic chemistry. Nowadays, the growing number of biocatalysts accessible by means of bioinformatics and enzyme engineering opens up an immense variety of reactions that can be performed selectively under mild conditions. Biocatalysis especially provides excellent opportunities for late‐stage modification...

17h

Cu(OTf)2‐Mediated Cross‐Coupling of Nitriles and N‐Heterocycles with Arylboronic Acids to Generate Nitrilium and Pyridinium Products

Metal‐catalyzed C–N cross‐coupling generally forms C–N bonds by reductive elimination from metal complexes bearing covalent C‐ and N‐ligands. We have identified a Cu‐mediated C–N cross‐coupling that uses a dative N‐ligand in the bond forming event, which, in contrast to conventional methods, generates reactive cationic products. Mechanistic studies...

1d

Enhanced light‐driven hydrogen production by self‐photosensitized biohybrid systems

Storage of solar energy as hydrogen provides a platform towards decarbonizing our economy. One emerging strategy for solar fuels production is to use photocatalytic biohybrid systems combining the high catalytic activity of non‐photosynthetic microorganisms with the high light‐harvesting efficiency of metal semiconductor nanoparticles. However, few...

1d

Cys‐Cys and Cys‐Lys Stapling of Unprotected Peptides Enabled by Hypervalent Iodine Reagents

Easy access to a wide range of structurally diverse stapled peptides is crucial for the development of inhibitors of protein‐protein interactions. Herein, we report bis‐functional hypervalent iodine reagents for two‐component cysteine‐cysteine and cysteine‐lysine stapling yielding structurally diverse thioalkyne linkers. This stapling method works with...

1d

Heterometallic Actinide‐Containing Photoresponsive Metal‐Organic Frameworks: Dynamic and Static Tuning of Electronic Properties

Acquiring fundamental knowledge of properties of actinide‐based materials is a necessary step to create new possibilities for addressing the current challenges in the nuclear energy and nuclear waste sectors. In this report, we established a photophysics‐electronics correlation for actinide‐containing metal‐organic frameworks (An‐MOFs) as a function...

1d

Synthesis of Anthracene‐Based Cyclic π‐Clusters and Elucidation of their Properties Originating from Congested Aromatic Planes

Anthracene‐based π‐congested cyclic dimer and tetramer were obtained using Ni(cod)2. These cyclic π‐clusters exhibit narrow HOMO–LUMO gaps, reflecting the face‐to‐face distance between the anthracene units. This π‐congestion endows the cyclic anthracene dimer with multi‐stimuli responsiveness such as photoisomerization and thermal reversion, accompanied...

1d

Selection and Characterization of an RNA‐Cleaving DNAzyme Activated by Legionella pneumophila

Legionella pneumophila is a pathogenic bacterium that exists in naturally occurring and man‐made water sources. Contaminations with these bacteria in cooling towers have led to fatal disease outbreaks. An RNA‐cleaving fluorogenic DNAzyme was isolated and found to selectively recognize Legionella pneumophila bacteria in cooling tower water. RNA‐cleaving...

1d

N,N‐Dialkylhydrazones as Versatile Umpolung Reagents in Enantioselective Anion‐Binding Catalysis

Networking for success: N,N‐Dialkylhydrazones have been identified as versatile nucleophiles with multiple‐networking ability to enable self‐assembled chiral contact ion pair complexation for enantioselective anion‐binding catalysis. The resulting network of highly ordered noncovalent interactions with the anion as a central template motif led to high...

1d

Bright and Robust Phosphorescence Achieved via Non‐Covalent Clipping

Phosphorescent compounds with high emission intensities are important for their practical applications, which require to lower the susceptibility of triplet excitons to surroundings. Herein a non‐covalent clipping strategy has been developed to attain this objective, by designing a tweezer receptor to encapsulate Pt(II)‐based triplet emitters via two‐fold...

1d

Porphyrinic Zirconium Metal–Organic Frameworks (MOFs) as Heterogeneous Photocatalysts for PET‐RAFT Polymerization and Stereolithography

Porphyrinic zirconium MOFs act as heterogeneous photocatalysts for photoinduced electron transfer‐reversible addition‐fragmentation chain transfer (PET‐RAFT) polymerization of various monomers under a broad range of wavelengths, producing polymers with high monomer conversions, narrow molecular weight distributions, low dispersity and good chain‐end...

1d