Ultrasmall Copper (I) Sulfide Nanoparticles Block Hepatitis B Virus

Hepatitis B virus (HBV) poses a severe threat to public health and social development. Here, we synthesized 4 ± 0.5 nm copper (I) sulfide (Cu 2 S) nanoparticles (NPs) with 46 mdeg chiroptical properties at 530 nm to selectively cleavage HBV core antigen (HBcAg) and effectively blocked HBV assembly and prevented HBV infection both in vitro and ...

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A Ratiometric Fluorescent Biosensor Reveals Dynamic Regulation of Long‐Chain Fatty Acyl‐CoA Esters Metabolism

Despite increasing awareness of the biological impacts of long‐chain fatty acyl‐CoA esters (LCACoAs), our knowledge about the subcellular distribution and regulatory functions of these acyl‐CoA molecules is limited by a lack of methods for detecting LCACoAs in living cells. Here, we report development of a genetically encoded fluorescent sensor that...

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High‐Rate CO2 Electroreduction to C2+ Products over a Copper‐Copper Iodide Catalyst

Electrochemical CO 2 reduction reaction (CO 2 RR) to multicarbon hydrocarbon and oxygenate (C 2+ ) products with high energy density and wide availability is of great importance, as it provides a promising way to achieve the renewable energy storage and close the carbon cycle. Herein we design a Cu‐CuI composite catalyst with abundant Cu/Cu +...

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Consecutive Nucleation and Confinement Modulation towards Li Plating in Seeded Capsules for Durable Li‐Metal Batteries

Lithium‐metal batteries (LMBs) stimulate the innovation of energy storage technologies due to the high theoretical capacity of lithium (Li) metal anode. However, the facile growth of Li dendrites and huge volume fluctuation virtually restrain the practical applications of LMBs. Herein, a dual modulation strategy of consecutive nucleation and confined...

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Effect of ligand backbone on the reactivity and mechanistic paradigm of non‐heme iron(IV)‐oxo during olefin epoxidation

Oxygen atom transfer (OAT) reactivity of a non‐heme [Fe IV (2PyN2Q)(O)] 2+ ( 2 ) containing sterically bulky quinoline‐pyridine pentadentate ligand (2PyN2Q) has been thoroughly studied with different olefins. The ferryl‐oxo complex 2 shows excellent OAT reactivity during epoxidations. The steric encumbrance and electronic effect of the ligand...

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Late‐Stage Heteroarylation of Hetero(aryl)sulfonium salts activated by α‐Amino Alkyl Radicals

We report a late‐stage heteroarylation of aryl sulfonium salts through activation with α‐amino alkyl radicals in a mechanistically distinct approach from previously reported halogen‐atom transfer (XAT).  The new mode of activation of aryl sulfonium salts proceeds in the absence of light and photoredox catalysts, engaging a wide range of hetarenes. Furthermore,...

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In vivo X‐ray triggered catalysis of H2 generation for cancer synergistic gas‐radiotherapy

To date, hydrogen (H2) therapy has received widespread attention. However, X‐ray triggered sustainable H2‐producing materials with controlled release for cancer treatment have not been reported. Herein, an X‐ray triggered sustainable in situ H2 producing platform, Au NR‐TiO2@ZnS:Cu,Co‐A(Au‐TiO2@ZnS), composed of Au‐amorphous TiO2 nano‐dumbbell‐shaped...

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Structural Transformative Antioxidants for Dual‐Responsive Anti‐Inflammatory Delivery and Photoacoustic Inflammation Imaging

Inflammation is mediated by various pathogenic factors including elevated reactive oxygen species (ROS). Glucocorticoids are widely used to reduce inflammation in many diseases, but their bioavailability is limited by rapid metabolism, poor water‐solubility, and harmful side‐effects. We here synthesize a PEGylated, phenylboronic acid‐modified L‐DOPA...

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Observing a Zeolite Nucleus (Subcrystal) with a Uniform Framework Structure and Its Oriented Attachment without Single‐molecule Addition

Multiple and complex crystallization process of zeolite including complementary single‐molecule condensation and particle assembly, and alternately dominant nucleation and growth behavior, plays the critical role in zeolite crystallization but meanwhile makes us hard to study the respective effects. Herein, we strip nuclei from the synthetic solution...

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Ammonia Formation Catalyzed by Dinitrogen‐Bridged Dirhenium Complex Bearing PNP‐Pincer Ligands under Mild Reaction Conditions

A series of rhenium complexes bearing a pyridine‐based PNP‐type pincer ligand are synthesized from rhenium phosphine complexes as precursors. A dinitrogen‐bridged dirhenium complex bearing the PNP‐type pincer ligands catalytically converts dinitrogen into ammonia during the reaction with KC8  as a reductant and [HPCy3 ]BArF4  (Cy = cyclohexyl, ArF...

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