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Self‐Healing of Hyaluronic Acid to Improve In Vivo Retention and Function

Modification of low molecular weight hyaluronic acid (HA) to exhibit self-healing properties enhances its in vivo longevity and lubrication function. Concomitant with these functions, intraarticular injection of self-healing HA mitigates joint injury-mediated cartilage degeneration in rodents following anterior cruciate ligament transection. Abstract...

Injectable Acylhydrazone‐Linked RAFT Polymer Hydrogels for Sustained Protein Release and Cell Encapsulation

A novel class of PADO polymers containing diacetone acrylamide, di(ethylene glycol) ethyl ether acrylate, and oligo(ethylene glycol) methyl ether acrylate are polymerized via reversible addition-fragmentation chain-transfer polymerization. Via acylhydrazone chemistry, the PADO polymers are crosslinked into pH/thermosensitive injectable hydrogel for...

Natural Biomaterials from Biodiversity for Healthcare Applications

Abstract Natural biomaterials originating during the growth cycles of all living organisms have been used for many applications. They span from bioinert to bioactive materials including bioinspired ones. As they exhibit an increasing degree of sophistication, natural biomaterials have proven suitable to address the needs of the healthcare sector. Here,...

Development of Nickel Selenide@polydopamine Nanocomposites for Magnetic Resonance Imaging Guided NIR‐II Photothermal Therapy

Abstract The penetration depth of near-infrared laser has greatly restricted the development of most photothermal agents. Recently, photothermal agents in the second near-infrared (NIR-II) window have drawn great attention as they can overcome above barrier. Herein, we report a novel “all in one” NIR-II responsive nanoplatform (nickel selenide @polydopamine...

Carbon‐Based Materials for Articular Tissue Engineering: From Innovative Scaffolding Materials toward Engineered Living Carbon

Carbon-based solutions in the area of osteochondral and articular repair and regeneration are emphasized by comprehensively reviewing the application of different carbon allotropes and the fabrication strategies employed to achieve the carbon scaffolds. Different challenges of the carbon-based scaffolds are discussed toward clinical applications. A...

Bioinspired Artificial Liver System with hiPSC‐Derived Hepatocytes for Acute Liver Failure Treatment

A new BBALS consists of hiPSC-Heps-laden GelMA microparticles and semipermeable microtubes. GelMA microparticles are served as excellent carriers for the hiPSC-Heps for better liver functions in vitro. The cell-laden microparticles are integrated with the semipermeable microtubes to enable efficient nutrient transport and toxins elimination. 3D liver...

Photoactivatable Biomedical Materials Based on Luminogens with Aggregation‐Induced Emission (AIE) Characteristics

Abstract Fluorescent probes with aggregation-induced emission (AIE) property have become fascinating and vital in biological fields due to their bright fluorescence in the solid state. In contrast traditional AIE materials are obscured by the off-target effects and the lack of spatial and temporal control. Photoactivatable materials with AIE characteristics,...

A spheroid model of early and late‐stage osteosarcoma mimicking the divergent relationship between tumour elimination and bone regeneration

Abstract Osteosarcoma is the most diagnosed bone tumour in children. The use of tissue engineering strategies after malignant tumour resection remains a subject of scientific controversy. As a result, there is limited research that focuses on bone regeneration post-resection, which is further compromised following chemotherapy. This study aims to develop...

Microfluidic Arrays of Breast Tumor Spheroids for Drug Screening and Personalized Cancer Therapies

Abstract One of the obstacles limiting progress in the development of effective cancer therapies is the shortage of preclinical models that capture the dynamic nature of tumor microenvironments. Interstitial flow strongly impacts tumor response to chemotherapy; however, conventional in vitro cancer models largely disregard this key feature. Here, we...

Three‐dimensional liver tissue model with branched vascular networks by multi‐materials bioprinting

Abstract Complicated vessels pervade almost all body tissues and influence the pathophysiology of the human body significantly. However, current fabrication strategies have limited success at multi-scale vascular biofabrication. This study reports a methodology to fabricate soft vascularized tissue at centimeter-scale using multi-material bioprinting...

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