In Situ Nucleic Acid Amplification and Ultrasensitive Colorimetric Readout in a Paper‐Based Analytical Device Using Silver Nanoplates

The combination of loop‐mediated isothermal amplification (LAMP) and silver nanoplates allows ultrasensitive colorimetric detection of methicillin‐resistant Staphylococcus aureus (MRSA), down to a single target copy, with easy qualitative readout by the naked eye and quantitative readout with a smartphone camera. Abstract A rapid, highly sensitive,...

19h

Particulate‐Based Single‐Dose Local Immunosuppressive Regimen for Inducing Tolerogenic Dendritic Cells in Xenogeneic Islet Transplantation

In this study, a robust immunosuppressive regimen is developed for tolerance induction in a xenogeneic islet transplantation model. Single‐dose of locally‐delivered particulate‐based regimen leads to indefinite survival of the islets transplanted into subcutaneous space of immunocompetent diabetic mice. Mechanistically, the combination of FK506 microspheres...

19h

T Cell‐Mediated Transport of Polymer Nanoparticles across the Blood–Brain Barrier

CD4+ helper T cells can be surface‐modified via thiol–maleimide chemistry with polymer nanoparticles. These modified cells can act as carriers that allow for the transport of the nanoparticle cargo across the blood–brain barrier both in vitro as well as in vivo. Abstract Delivery of therapeutics to the central nervous system (CNS) is challenging...

19h

Nano versus Molecular: Optical Imaging Approaches to Detect and Monitor Tumor Hypoxia

Hypoxia is a ubiquitous feature of solid tumors, which plays a key role in tumor resistance. Optical sensors provide high spatiotemporal resolution and enable real‐time detection for hypoxia imaging. This review provides a comprehensive overview of the hypoxia analytes and the latest nano‐ and molecular developments in various optical imaging approaches...

19h

Biomaterials Regulating Bone Hematoma for Osteogenesis

The importance of hematoma formation during osteogenesis is reviewed and the effect of biomaterials on blood coagulation, fibrin network structures, growth factor release, and stem cell recruitment is highlighted. The paper points to the future development of functional bone biomaterials targeting hematoma and early bone healing process for osteogenesis....

1d

In Situ Nucleic Acid Amplification and Ultrasensitive Colorimetric Readout in a Paper‐Based Analytical Device Using Silver Nanoplates

The combination of loop‐mediated isothermal amplification (LAMP) and silver nanoplates allows ultrasensitive colorimetric detection of methicillin‐resistant Staphylococcus aureus (MRSA), down to a single target copy, with easy qualitative readout by the naked eye and quantitative readout with a smartphone camera. Abstract A rapid, highly sensitive,...

1d

Particulate‐Based Single‐Dose Local Immunosuppressive Regimen for Inducing Tolerogenic Dendritic Cells in Xenogeneic Islet Transplantation

In this study, a robust immunosuppressive regimen is developed for tolerance induction in a xenogeneic islet transplantation model. Single‐dose of locally‐delivered particulate‐based regimen leads to indefinite survival of the islets transplanted into subcutaneous space of immunocompetent diabetic mice. Mechanistically, the combination of FK506 microspheres...

1d

T Cell‐Mediated Transport of Polymer Nanoparticles across the Blood–Brain Barrier

CD4+ helper T cells can be surface‐modified via thiol–maleimide chemistry with polymer nanoparticles. These modified cells can act as carriers that allow for the transport of the nanoparticle cargo across the blood–brain barrier both in vitro as well as in vivo. Abstract Delivery of therapeutics to the central nervous system (CNS) is challenging...

1d

Nano versus Molecular: Optical Imaging Approaches to Detect and Monitor Tumor Hypoxia

Hypoxia is a ubiquitous feature of solid tumors, which plays a key role in tumor resistance. Optical sensors provide high spatiotemporal resolution and enable real‐time detection for hypoxia imaging. This review provides a comprehensive overview of the hypoxia analytes and the latest nano‐ and molecular developments in various optical imaging approaches...

1d

Thermo‐Triggered In Situ Chitosan‐Based Gelation System for Repeated and Enhanced Sonodynamic Therapy Post a Single Injection

A hybrid thermo‐triggered in situ hydrogel system is designed to realize the long‐term local retention of therapeutic agents to reinforce the gel structure in tumors and persistent tumorous hypoxia relief. For mice with a single‐dose injection of precursor solution and multiple rounds of ultrasonic treatments, the repeated SDT could offer the robust...

1d