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Bioengineered 3D living fibers as in vitro human tissue models of tendon physiology and pathology

Abstract Clinically relevant in vitro models of human tissue's health and disease are urgently needed for a better understanding of biological mechanisms essential for the development of novel therapies. Herein, the physiological (healthy) and pathological (disease) tendon states are bioengineered by coupling the biological signaling of platelet lysate...

Magnesium Oxide/Poly (L‐lactide‐co‐ε‐caprolactone) Scaffolds Loaded with Neural Morphogens Promote Spinal Cord Repair through Targeting the Calcium Influx and Neuronal Differentiation of Neural Stem Cells

Abstract Because of the limited regenerative ability of the central nervous system (CNS), effective treatments for spinal cord injury (SCI) are still lacking. After SCI, neuron loss and axon regeneration failure often result in irreversible functional impairment. The calcium overload induced by the N-methyl-D-aspartate receptor (NMDAR) overactivation...

Nanofiber Topographies Enhance Platelet‐Fibrinogen Scaffold Interactions

Fibrinogen is a natural component of blood clots and a candidate material for wound dressings. Here, fibrinogen coatings of different topography are demonstrated to activate platelets to different degrees. It is uncovered that the increased surface area of 3D fibrinogen nanofibers favors platelet noncoagulant responses, while plasma components render...

Supramolecular Detoxification of Macromolecular Biotoxin through the Complexation by a Large‐Sized Macrocycle

A novel water-soluble quaterphen[4]arene baring dendritic multicarboxylate moieties (H) exhibits an overall host–guest complexation toward macromolecular biotoxins and biotoxin encapsulation significantly inhibits its cytotoxicity and hemolytic activity. An in vivo assay verifies that the intravenous administration of H markedly improves the survival...

Near‐Infrared‐Enpowered Nanomotor‐Mediated Targeted Chemotherapy and Mitochondrial Phototherapy to Boost Systematic Antitumor Immunity

Antheraea pernyi silk fibroin-capped mesoporous silicon nanoparticles with multiresponsibility are facilely developed to deliver the payloads to specific organelles of tumor cells. These nanomotors can penetrate into the internal tumor tissues, self-produce oxygen, achieve multimodal image-guided mitochondrial phototherapy, and further exert synergistic...

Acid‐Responsive Nanoporphyrin Evolution for Near‐Infrared Fluorescence‐Guided Photo‐Ablation of Biofilm

The near-infrared (NIR) fluorescence monitoring with synergistic photodynamic therapy (PDT) and photothermal therapy (PTT) of PN3-NP can be activated by the acidity in biofilms accompanied by the nano-structural evolution, which not only enhances the adhesion of PN3-NP to the bacteria but also avoids damage to normal cells, endowing it an ideal photosensitizer...

NIR‐II J‐Aggregated Pt(II)‐Porphyrin‐Based Phosphorescent Probe for Tumor‐Hypoxia Imaging

Abstract The luminescence of traditional phosphorescence-based hypoxia probes is limited to the visible and first near-infrared wavelength regions (<1,000 nm), which has defects of higher light scattering and lower penetration depth in contrast with the second near-infrared wavelength window (NIR-II, 1,000-1,700 nm) for optical bioimaging. Herein,...

Low Surface Accessible Area NanoCoral TiO2 for the Reduction of Foreign Body Reaction During Implantation

Low surface accessible area NanoCoral (NC) reduces foreign body reaction (FBR) by interfering High Mobility Group Box 1 (HMGB1). Unstable end of HMGB1 has better adsorption on NC, causing the reduction of cysteine (CYS) exposure to Toll-like receptor 4 (TLR4), thus suppressing dendritic cell (DC) aggregation and activation via TLR4-Myd88-NF-κB pathway....

Injectable Dual‐Dynamic‐Bond Cross‐Linked Hydrogel for Highly Efficient Infected Diabetic Wound Healing

A dual-dynamic-bond cross-linked hydrogel is synthesized using tissue-friendly micromolecules for infected diabetic wound treatment. The hydrogel dissolves rapidly in wounds and releases chemicals that can be completely absorbed and directly utilized for tissue regeneration. In vivo experiments indicate that the healing rate of the dual-dynamic-bond...

Charge‐Transfer Complex Combining Reduced Cluster with Enhanced Stability for Combined Near‐Infrared II Photothermal Therapy

An ionic complex of a reduced cluster combining with charge-transfer complex (CTC) is prepared via a spontaneously mutual redox for enhanced stability and combined near-infrared (NIR)-II photothermal therapy. The redox provides the reduced cluster and CTC with strong absorption bands in the NIR region, and pH-sensitive aggregation allows the ionic complex...

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