OVAnano, a biomimetic nanocapsule, emulates extracellular vesicles to optimize antigen delivery and stimulate dendritic cell maturation through the NF-κB activation pathway. Vaccination with OVAnano can inhibit tumor growth and support the development of long-lasting immune memory in vivo. Abstract The development of nanovaccines capable...

An innovative in situ vaccine strategy that αOX40 and resiquimod (R848) are modified to the surface of L. lactis, resulting in the generation of dual immune adjuvant modified L. lactis (OR@Lac) are presented. Then, OR@Lac in combination with ibrutinib significantly alleviated or even completely inhibited tumor growth in tumor-bearing mice. ...

The use of bacteria has shown promising potential for tumor therapy. The rational engineered bacteria based biohybrid living system is discussed for tumor therapy in this review, including the natural antitumor mechanism of bacteria, the genetic modification to bacteria as living delivery system and the combination of bacteria with functional materials...

Creating durable, conductive interfaces is crucial for studying and treating brain disorders. Here a versatile method is described to graft a block copolymer from gold surfaces, enhancing stability without sacrificing electrical properties. This “block-brush” coating exhibits high capacitance, strong adhesion, and improved stability against voltage...

To achieve pyroptosis of tumor cells, engineered cellular nanovesicles presenting TRAIL (NVTRAIL) are developed to trigger the upregulation of cleaved caspase-3, and chemotherapeutic agent mitoxantrone (MTO) is employed to enhance GSDME expression. Consequently, MTO@NVTRAIL are able to convert cancer cells from apoptosis into pyroptosis, effectively...

A porous DNA-based nano-vehicle is developed through the integration of coordination self-assembly and cryo-engineering for the customized delivery of theranostic agents to meet desired requirements. The supramolecular modulator enables the adaptive porous structure to allow plug-and-play encapsulation of diverse payloads without redesigning the system....