Conductive Anti‐fouling Sensing Coating: A Bionic Design Inspired by Natural Cell Membrane

Abstract Constructing antifouling coatings for biosensing interfaces is a major hurdle in driving their practical application. Inspired by the excellent antifouling properties of natural cell membranes, we propose a conductive biomimetic antifouling interface coating-CBmAI, which highly mimics the excellent antifouling properties of biofilms while...

8h

Injectable Intrinsic Photothermal Hydrogel Bioadhesive with On‐Demand Removability for Wound Closure and MRSA‐Infected Wound Healing

Abstract Photothermal hydrogel adhesives have yielded promising results for wound closure and infected wound treatment in recent years. However, photothermal hydrogel bioadhesives with on-demand removability without additional nanomaterials-based photothermal agents have rarely been reported in the literature. In this work, an injectable intrinsic...

8h

A Biomimetic Lubricating Nanosystem with Responsive Drug Release for Osteoarthritis Synergistic Therapy

Abstract Osteoarthritis (OA) is associated with lubrication failure of articular cartilage and severe inflammatory response of joint capsule. Synergistic therapy combining joint lubrication and anti-inflammation emerges as a novel treatment of OA. In this study, bioinspired by ultra-low friction of natural articular synovial fluid and mussel adhesion...

8h

GelMA and Biomimetic Culture Allow the Engineering of Mineralized, Adipose and Tumor Tissue Human Microenvironments for the Study of Advanced Prostate Cancer In Vitro and In Vivo

Abstract Increasing evidence shows bone marrow (BM)-adipocytes as a potentially important contributor in prostate cancer (PCa) bone metastases. However, a lack of relevant models has prevented to fully understand the effects of human BM-adipocytes in this microenvironment. We hypothesized that the combination of tunable gelatin methacrylamide (GelMA)-based...

8h

Stimuli‐Responsive Self‐degradable DNA Hydrogel: Design, Synthesis and Applications

Abstract DNA hydrogels play an increasingly important role in biomedicine and bioanalysis applications. Due to the high programmability, multifunctionality and biocompatibility, they are often used as effective carriers for packing drugs, cells, or other bioactive cargoes in vitro and in vivo. However, the stability of the DNA hydrogels prevents their...

1d

An Instant Underwater Tissue Adhesive Composed of Catechin‐Chondroitin Sulfate and Cholesterol‐Polyethyleneimine

Abstract Due to the safety issue and poor underwater adhesion of current commercially available bioadhesives, they are hard to apply to in vivo physiological environments and more diverse medical use conditions. In this study, a novel and facile bioadhesive for underwater medical applications was  designed based on the coacervation of electrostatic...

1d

Architecture‐Engineered Electrospinning Cascade Regulates Spinal Microenvironment to Promote Nerve Regeneration

A hydrogel “perfusion” system and electrospinning technology constitute a “concrete” composite support for the repair of nerve injuries. This engineering fiber composite improves the local inflammatory response and promotes nerve regeneration through a hydrophilic programmed cytokine-delivery system, which further improves and supplements the immune...

1d

Melatonin‐Primed Mesenchymal Stem Cells‐Derived Small Extracellular Vesicles Alleviated Neurogenic Erectile Dysfunction by Reversing Phenotypic Modulation

MT-EVs nanoparticles are potential therapeutic vectors, or bioactive materials for cavernous nerve injury erectile dysfunction (CNI ED). MT-EVs exert their therapeutic effects by delivering miR-10a-3p to target protein kinase inhibitor α (PKIA) in cavernosum smooth muscle cells (CSMC), reversing the phenotypic modulation of CSMC via the miR-10a-3p/PKIA/RhoA/ROCK...

1d

Endogenous Electric Field‐Coupled PD@BP Biomimetic Periosteum Promotes Bone Regeneration through Sensory Nerve via Fanconi Anemia Signaling Pathway

Promoting osteogenesis through nerve regeneration in the periosteum is an exciting field. Electrically active biomimetic periosteum regulates the transformation of Schwann cells into repair phenotype, then regulates the concentration of axon initial segment (AIS)and calcium ions in the sensory nerve, as well as the release of dense core vesicle (DCV),...

1d

Microphysiological Drug‐Testing Platform for Identifying Responses to Prodrug Treatment in Primary Leukemia

The authors present a microphysiological platform to recapitulate the metabolic activation of prodrugs in vitro for personalized drug screening against leukemia. The platform enables the co-culture of primary leukemia cells, stromal cells, and liver microtissues in a microfluidic network. Sample-specific sensitivities to short-lived ifosfamide metabolites...

1d