Advanced Healthcare Materials

Wiley Online Library : Advanced Healthcare Materials

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Wavelength‐Selective Light‐Controlled Stepwise Photolysis from Single Gold Nanoparticles

A light‐controlled sequential photolysis system is developed based on gold nanoparticles to release payloads in a wavelength‐dependent manner. With this system, stepwise, wavelength‐selective payload release is realized from single nanoparticle in live cells. The ability of light‐induced sequential release is ultimately useful to provide approaches...

Human Oral Motion‐Powered Smart Dental Implant (SDI) for In Situ Ambulatory Photo‐biomodulation Therapy

An ambulatory photo‐biomodulation therapy using a seamless, human oral motion‐powered Smart Dental Implant (SDI) is presented. Under chewing and brushing motions, the piezoelectric dental crown activates a micro‐light emitting diodes (LED) via an associate circuitry. Using primary human gingival keratinocytes as a model host and P. aeruginosa LPS as...

Artificial Intelligence and Machine Learning in Computational Nanotoxicology: Unlocking and Empowering Nanomedicine

Artificial intelligence and machine learning in computational nanomedicine are making great strides in nanoparticle‐modified theranostics design and development. The quantitative structure–activity relationships at nanoscale, physiologically based pharmacokinetic, absorption, distribution, metabolism, and excretion, and dosimetry‐based advanced computational...

Engineered Perineural Vascular Plexus for Modeling Developmental Toxicity

Current models of in vitro brain development fail to mimic mechanisms in vivo, partly as they use animal‐derived matrices. The current study incorporates differentiated cell lines in a fabricated synthetic hydrogel in a microfluidics plate to recapitulate perineural vascular plexus in vivo. By analyzing endpoints such as growth factors, metabolites...

Human Oral Motion‐Powered Smart Dental Implant (SDI) for In Situ Ambulatory Photo‐biomodulation Therapy

An ambulatory photo‐biomodulation therapy using a seamless, human oral motion‐powered Smart Dental Implant (SDI) is presented. Under chewing and brushing motions, the piezoelectric dental crown activates a micro‐light emitting diodes (LED) via an associate circuitry. Using primary human gingival keratinocytes as a model host and P. aeruginosa LPS as...

DNA Hybridization Measured with Graphene Transistor Arrays

Arrays of field‐effect transistors are fabricated from chemical vapor deposition grown graphene and DNA hybridization is detected down to femtomolar concentrations. A thin protection layer prevents contamination of graphene during photolithographic patterning and hybridization. DNA probes are electrostatically immobilized. Hybridization of target DNA...

Designer Descemet Membranes Containing PDLLA and Functionalized Gelatins as Corneal Endothelial Scaffold

Innovative ultrathin carriers for corneal endothelial cells are developed that consisted of a polyester base and a top layer of gelatin. The membranes supported the characteristic hexagonal morphology and correct phenotype of corneal endothelial cells while exhibiting similar growth rates as the positive control. As a consequence, the proposed membranes...

An Oxidation‐Enhanced Magnetic Resonance Imaging Probe for Visual and Specific Detection of Singlet Oxygen Generated in Photodynamic Cancer Therapy In Vivo

A magnetic resonance imaging probe is constructed by co‐encapsulation of superparamagnetic Fe3O4 nanoparticles and photosensitizer Ce6 in oxidation‐responsive micelles for in vivo visual detection of singlet oxygen generated in photodynamic cancer therapy. Abstract Singlet oxygen is regarded as the primary cytotoxic agent in cancer photodynamic...

Flexible and Stretchable Temperature Sensors Fabricated Using Solution‐Processable Conductive Polymer Composites

Solution‐processed conductive polymer composites (CPCs) are patterned on both flexible and stretchable substrates through both drop‐coating and direct ink writing (DIW), forming sensitive temperature sensors. The composite ink comprises a high melting point biopolymer matrix (polyhydroxybutyrate [PHB]) and reduced graphene oxide (rGO) nanofiller (from...

Bioresorbable, Wireless, Passive Sensors as Temporary Implants for Monitoring Regional Body Temperature

Fully bioresorbable, wireless, battery‐free temperature sensors enable measurements of local internal body temperatures over clinically relevant timeframes and then ultimately disappear completely in the body, thereby eliminating the need for extraction surgeries. Potential applications include monitoring of processes associated with wound healing and...

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