Advanced Healthcare Materials

Wiley Online Library : Advanced Healthcare Materials

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Near Infrared‐Activatable Platinum‐Decorated Gold Nanostars for Synergistic Photothermal/Ferroptotic Therapy in Combating Cancer Drug Resistance

Platinum‐decorated gold nanostars (Pt‐AuNS) as a novel metal nanoprodrug for combined photothermal‐ferroptotic therapy to combat cancer drug resistance. Upon NIR irradiation, the active metallic (Pt and Au) payloads are released, inducing selective cancer cell death. The mechanism of action is attributed to the intracellular GSH depletion and GPX4 inactivation,...

Engineering of a Core–Shell Nanoplatform to Overcome Multidrug Resistance via ATP Deprivation

The GOx and DOX are co‐loaded into core–shell MPDA/ZIF‐8 nanosystem to realize starvation‐therapy and enhanced‐chemotherapy. The first released GOx via acid‐triggered ZIF‐8 degradation starves cancer cells, leading to ATP deprivation to suppress P‐gp function. The subsequent release of DOX could efficiently be accumulated for conquering MDR of cancer...

Bacteria‐Derived Nanoparticles: Multifunctional Containers for Diagnostic and Therapeutic Applications

Bacteria‐derived materials have provided remarkable flexibility in applied biomedical functionalization. Several bacteria‐derived materials are approved in clinical application, indicating their advantages and great potential. Here, bacteria‐derived nanoparticles are focused as a promising biomaterial, introducing several bacterial species with great...

Ultrathin and Robust Hydrogel Coatings on Cardiovascular Medical Devices to Mitigate Thromboembolic and Infectious Complications

Thromboembolic and infectious complications associated with use of cardiovascular devices remain common and increase patient morbidity and mortality. Currently, no single technology addresses these challenges. Here, it is shown that applying a thin hydrogel layer onto medical tubing reduces friction and the adhesion of bacteria and blood components....

Polymers for Melt Electrowriting

Melt electrowriting is a 3D‐printing technology that is increasingly investigated for biomedical applications. This review focuses on the different polymers used with this technology so far and provides a future perspective for additional requirements needed for melt electrowriting printers to help expand the possible processable materials and designs....

Biofabrication of Hepatic Constructs by 3D Bioprinting of a Cell‐Laden Thermogel: An Effective Tool to Assess Drug‐Induced Hepatotoxic Response

Self‐assembled hepatic constructs in 3D direct‐write bioprinted cell‐laden thermogels are used to evaluate in vitro acetaminophen‐induced hepatotoxic response. Abstract A thermoresponsive Pluronic/alginate semisynthetic hydrogel is used to bioprint 3D hepatic constructs, with the aim to investigate liver‐specific metabolic activity of the...

Bioinspired Dopamine/Mucin Coatings Provide Lubricity, Wear Protection, and Cell‐Repellent Properties for Medical Applications

Bioinspired dopamine/mucin double‐layer coatings, using dopamine as a glue molecule between the substrate and mucin macromolecules, an easy method for establishing non‐covalent mucin coatings onto different substrates is presented. The generated double‐layer coatings demonstrate low friction, wear protection and anti‐biofouling properties on various...

Review of Integrin‐Targeting Biomaterials in Tissue Engineering

Integrin‐targeting biomaterials can be used to guide cell behavior for improved tissue regeneration. This review summarizes integrin‐mediated cellular responses involved in bone regeneration, angiogenesis, and wound healing processes. Design considerations in the development of integrin‐targeting biomaterials to harness these interactions to improve...

Highly Stretchable Metal–Polymer Conductor Electrode Array for Electrophysiology

Based on the liquid metal–polymer conductor, a stretchable electrode array (SEA) is developed for in vitro electrophysiology. The SEA exhibits high stretchability and stable electrical properties. The excellent cytocompatability of the SEA can allow for long‐term culturing of primary neurons and enable signal recording of primary hippocampal neurons....

Implantable Nanosensors for Human Steroid Hormone Sensing In Vivo Using a Self‐Templating Corona Phase Molecular Recognition

A hydrogel‐encapsulated carbon nanotube biosensor detects the steroid hormone progesterone in the subcutaneous space of mice. The biosensor is synthesized using a polymeric, self‐templated corona phase molecular recognition (CoPhMoRe) strategy, which is adaptable to target other steroid hormones, including cortisol. The progesterone and cortisol biosensors...

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