Abstract Cancer is indisputably one of the major threats to mankind and hence the design of new approaches for the improvement of existing therapeutic strategies is always wanted. Herein, the design of a TME-responsive, DNA-based CDT nanoagent with dual Fenton reaction centers for targeted cancer therapy is reported. Self-assembly of DNA amphiphile...

Abstract Bionic tissues offer an exciting frontier in biomedical research by integrating biological cells with artificial electronics, such as sensors. One critical hurdle is the development of artificial electronics that can mechanically harmonize with biological tissues, ensuring a robust interface for effective strain transfer and local deformation...

Abstract The foreign body response (FBR) is an immune-mediated reaction that can occur with most biomaterials and biomedical devices. The FBR initiates a deterioration in the performance of implantable devices, representing a longstanding challenge that has consistently hampered their optimal utilization. Over the last decade, significant strides have...

Cancer cells have a remarkable capacity to dynamically adapt to fluctuations in extracellular viscosity. Here HepG2 human hepatoma cell spheroids are cultivated within 3D microcapsule reactors created using the high-throughput droplet-based microfluidics. The image showcases alterations in the expression and distribution of F-actin and keratin 8 in...

An innovative strategy for creating deformable soft microfluidic channels is proposed for the development of in vitro artificial vasculature with composite mechanically responsive microenvironments. The microfluidic circular channel walls in the system are made of thin membranes that generate arterial-like pulsations in response to physiological levels...

Monocyte-adherent “backpacks” are reported to be modified with interferon gamma (IFNγ) to stimulate resultant macrophages into a pro-inflammatory, antitumor phenotype, a strategy referred to as Ornate Polymer backpacks on Tissue Infiltrating Monocytes (OPTIMs). Abstract Adoptive cell therapies are dramatically altering the treatment landscape...