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Fibrous Systems as Potential Solutions for Tendon and Ligament Repair, Healing, and Regeneration

The literature of fiber‐based systems for tendon and ligament repair, healing and regeneration is reported. Fibrous scaffolds including strand fibers, woven, knitted, braided and braid‐twisted fibrous constructs, electrospun and wet‐spun structures, as well as multilayered systems are critically reviewed and described, pointing out advantages and drawbacks...

Nanotechnology‐Based Strategies to Evaluate and Counteract Cancer Metastasis and Neoangiogenesis

Nanomaterials can be used as detection and therapeutic agents to combat cancer metastasis and angiogenesis, owing to their unique characteristics which allow tailored and tunable functions. Abstract Cancer metastasis is the major cause of cancer‐related morbidity and mortality. It represents one of the greatest challenges in cancer therapy,...

Highly Stretchable, Adhesive, and Self‐Healing Silk Fibroin‐Dopted Hydrogels for Wearable Sensors

The silk fibroin‐dopted double network hydrogel prepared by the one‐pot method of thermal polymerization improves sensitivity by 59%, showing up to 2000% tensile deformation, as well as remarkable peel strength. As a flexible resistance‐type pressure sensor, it can detect human motion, both notable and subtle, which has promising applications for electronic...

Effective Intratumoral Retention of [103Pd]AuPd Alloy Nanoparticles Embedded in Gel‐Forming Liquids Paves the Way for New Nanobrachytherapy

As a new concept for brachytherapy, 103Pd‐radiolabeled gold‐palladium nanoparticles are hydrophobically coated and formulated in a carbohydrate‐based liquid. Upon injection, the liquid solidifies, forming brachytherapy‐seed like “nanogels”. The coating allows excellent retention of the nanoparticles in the gel, demonstrated both in vitro and in tumor‐bearing...

One‐Step All‐Aqueous Interfacial Assembly of Robust Membranes for Long‐Term Encapsulation and Culture of Adherent Stem/Stromal Cells

Robust polymeric capsules are produced using a one‐step rapid process based on the interfacial complexation of oppositely charged polyelectrolytes in an all‐aqueous environment. Two processing methodologies are used to produce millimetric or micrometric capsules and characterized regarding their size dispersity, thickness, robustness, and porosity....

Dual‐Cues Laden Scaffold Facilitates Neurovascular Regeneration and Motor Functional Recovery After Complete Spinal Cord Injury

A dual‐cues laden hydrogel scaffold is able to synergistically promote vascular reformation and axon regeneration in the lesion epicenter post complete spinal cord injury (SCI). Moreover, implantation of the dual‐cues laden scaffold could also effectively reduce chondroitin sulfate proteoglycans and fibronectin deposition in the lesion area and improve...

Stabilization of Damaged Articular Cartilage with Hydrogel‐Mediated Reinforcement and Sealing

A modularly designed biomaterial approach is used to stabilize damaged articular cartilage. Interdigitating reinforcement of degenerated tissue with the hyaluronic acid‐based material improves multiscale mechanical properties and restores chondrocyte behavior. The biomaterial is then functionalized to improve mesenchymal stem/stromal cells (MSCs) adhesion...

Recent Progress of Alkyl Radicals Generation‐Based Agents for Biomedical Applications

Currently, alkyl radicals have attracted many attentions since they can be produced without oxygen participation for anticancer and antibacterial applications. This review summarizes the developed agents that are exploited in this kind of oxygen‐independent alkyl radicals therapy based on their components including inorganic, organic, and hybrid system....

Facile Synthesis of a Croconaine‐Based Nanoformulation for Optoacoustic Imaging and Photothermal Therapy

CR760, a croconaine dye with excellent optical properties, is synthesized in a single step and subsequently nanoformulated for optoacoustic imaging and photothermal therapy of cancer. Abstract Near‐infrared (NIR) light absorbing theranostic agents can integrate optoacoustic imaging and photothermal therapy for effective personalized precision...

Therapeutic Ultrasound Triggered Silk Fibroin Scaffold Degradation

Biomaterials are designed with set degradation profiles. However, some patients require fast degrading biomaterials to avoid an inappropriate immune response and fibrotic capsules; while others require slow degrading biomaterials to enhance cellular and vascular infiltration. Since predicting regenerative rate prior to implantation is currently not...

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