Here, adual-enzyme activity hydrogel is developed for Staphylococcus aureus-infected pressure ulcers (IPUs). It contains dopamine methacrylamide (DMA), methacrylate-modified silk fibroin (SFMA), and nanoplatforms (HNTs-Fe-Ag), showing peroxidase (POD)-like activity in acidic conditions and catalase (CAT)-like activity in alkaline conditions. This...

The hADSCs@rHCIII hydrogel promotes diabetic wound healing by providing a 3D stem cell niche for hADSCs encapsulation and delivery. It aids the healing process by playing distinct roles during the inflammation, proliferation, and remodeling phases, contributing to enhanced tissue regeneration and overall wound recovery throughout the different stages...

Local delivery of bilayer FTY720-nanofiber scaffolds in an oronasal fistula mouse model promotes complete wound closure by modulating pro-regenerative immune and stromal cells. Abstract Orofacial clefts are the most common congenital craniofacial anomaly. Adverse healing following cleft palate repair can lead to oronasal fistula (ONF), a...

Based on the CB[10]-oriented host–guest recognition, two water-soluble supramolecular porphyrins are developed to implement selective bactericidal effect via in situ bacteria-responsive NIR PTT. Owing to the matching reduction potential with facultative anaerobic E. coli, supramolecular porphyrins are selectively reduced into supramolecular phlorin...

This review focuses on the latest advancements in nanozymes for combating bacterial drug resistance, emphasizing their design, structural characteristics, applications in combination therapy, and future prospects. This approach aims to promote nanozyme development for combating bacterial drug resistance, especially towards clinical translation. ...

This review introduces the unique properties of iron-based metal–organic frameworks (Fe-MOFs), the advances in synthesis and formulation, and their state-of-the-art applications in biomedicine. It discusses the challenges in transitioning Fe-MOFs from research to clinical use, emphasizing the need for eco-friendly production methods, and a deeper...