Wiley Online Library : Advanced Healthcare Materials
2k followers 43 articles/week
Hierarchical Design of Tissue‐Mimetic Fibrillar Hydrogel Scaffolds

Abstract Most tissues of the human body present hierarchical fibrillar extracellular matrices that have a strong influence over their physicochemical properties and biological behavior. Of great interest is the introduction of this fibrillar structure to hydrogels, particularly due to the water-rich composition, cytocompatibility and tunable properties...

Sat Feb 24, 2024 12:57
Surface Modification of Nerve Guide Conduits with ECM Coatings and Investigating Their Impact on Schwann Cell Response

Abstract In this study, we investigated surface modification through the layer-by-layer method as a straightforward and highly stable approach for depositing layers of natural polymers onto a commercial nerve guide conduit (NGC), thereby mimicking the extracellular matrix. The application of NGCs for nerve regeneration is constrained by the size of...

Sat Feb 24, 2024 12:57
Deterministic Single‐Cell Encapsulation in PEG Norbornene Microgels for Promoting Anti‐Inflammatory Response and Therapeutic Delivery of Mesenchymal Stromal Cells

A microfluidic-based platform is developed for the encapsulation of viable single MSCs into microgels with high efficiency and throughput. The encapsulation of single MSCs stimulates favorable trophic factor expression and secretion and provides administrable cell-laden microgels with prolonged retention time in vivo. Delivery of MSC-laden microgels...

Sat Feb 24, 2024 12:57
A 3D Bioprinted Human Neurovascular Unit Model of Glioblastoma Tumor Growth

Abstract A 3D bioprinted neurovascular unit (NVU) model was developed to study glioblastoma (GBM) tumor growth in a brain-like microenvironment. The NVU model included human primary astrocytes, pericytes and brain microvascular endothelial cells, and patient-derived glioblastoma cells (JHH-520) were used for this study. We used fluorescence reporters...

Sat Feb 24, 2024 12:57
A Bionic Thermosensitive Sustainable Delivery System for Reversing the Progression of Osteoarthritis by Remodeling the Joint Homeostasis

Abstract Although the pathogenesis of osteoarthritis (OA) is unclear, inflammatory cytokines are related to its occurrence. However, few studies focused on the therapeutic strategies of regulating joint homeostasis by simultaneously remodeling anti-inflammatory and immunomodulatory microenvironment. Fibroblast growth factor 18 (FGF18) is the only disease-modifying...

Sat Feb 24, 2024 12:57
Recording Quality Is Systematically Related to Electrode Impedance

Electrode coatings bringing the impedance of small electrodes closer to the impedance of large ones and allow increased spike selectively without sacrificing the SNR and unit-yield. This study shows that in chronic recordings, signal quality and unit yield are negatively correlated with electrode impedance. This analysis is based on electrodes of...

Sat Feb 24, 2024 12:57

Build your own newsfeed

Ready to give it a go?
Start a 14-day trial, no credit card required.

Create account