Site‐Selective, Multistep Functionalizations of CO2‐Based Hyperbranched Poly(alkynoate)s toward Functional Polymetric Materials

Hyperbranched poly(alkynoate)s are facilely prepared from CO2, serving as a versatile platform for site‐selective multistep functionalizations, based on which polyprodrug amphiphiles with high drug loading content, artificial light‐harvesting system with high energy transfer efficiency and white light‐emitting system are constructed. Abstract...

10h

RNAi Screening Identifies that TEX10 Promotes the Proliferation of Colorectal Cancer Cells by Increasing NF‐κB Activation

This study performs genome‐wide RNA interference (RNAi) screening to identify testis expressed 10 (TEX10) as an essential gene in colorectal cancer (CRC). Upregulation of TEX10 in CRC is associated with poor prognosis of patients. TEX10 interacts with RELA and increases its nuclear localization, therefore stimulating the expression of a subset of RELA‐targeted...

1d

An Organic Borate Salt with Superior p‐Doping Capability for Organic Semiconductors

The salt of the cation (Mes2B+; Mes: mesitylene) and the anion [B(C6F5)4]− is introduced as superior p‐type dopant for organic semiconductors. The doping mechanism involves electron transfer from the semiconductor to Mes2B+, and the positive charge is stabilized by [B(C6F5)4]−. For poly(3‐hexylthiophene), the anion even stabilizes bipolarons. The effective...

2d

HGF Mediates Clinical‐Grade Human Umbilical Cord‐Derived Mesenchymal Stem Cells Improved Functional Recovery in a Senescence‐Accelerated Mouse Model of Alzheimer's Disease

This study explores the effects of clinical‐grade hUC‐MSCs on the recovery of cognitive ability of Alzheimer's disease (AD). All results uncover that HGF secreted from hUC‐MSCs, mediates the beneficial effects of hUC‐MSCs on functional recovery of damaged neural cells by downregulating hyperphosphorylated tau, improving neurofibrillary tangles, reversing...

2d

Porous Pt Nanospheres Incorporated with GOx to Enable Synergistic Oxygen‐Inductive Starvation/Electrodynamic Tumor Therapy

Porous platinum nanospheres (pPts) incorporated with glucose oxidase (GOx) molecules (PtGs) are synthesized for synergistic electrodynamic/starvation therapy. Despite its feasible loading for GOx, pPt enables sufficient O2 supply to facilitate GOx‐mediated starvation by decomposing H2O2. Meanwhile, PtG induces reactive oxygen species (ROS) under an...

2d

Tailoring Artificial Mode to Enable Cofired Integration of Shear‐type Piezoelectric Devices

This work reports an ingenious metamaterial‐inspired methodology to first realize cofired manufacture of multilayer shear‐type piezoelectric devices, which is a long‐term challenge in piezoelectric techniques. The artificially prototype d36‐mode device shows enhanced shear‐type displacement output by over 20 times beyond previous d15‐mode bulk one at...

2d

22% Efficiency Inverted Perovskite Photovoltaic Cell Using Cation‐Doped Brookite TiO2 Top Buffer

A composite consisting of 1D cation‐doped TiO2 brookite nanorod embedded by 0D fullerene is investigated as a top modification buffer for inverted perovskite photovoltaic (IP‐PV) cells. The resultant IP‐PV displays an efficiency exceeding 22% with a favorable stability. This work opens up more opportunities in expanding the material inventory for charge...

6d

WB5−x: Synthesis, Properties, and Crystal Structure—New Insights into the Long‐Debated Compound

New boron‐rich tungsten boride WB5− x is synthesized in an experiment, its precise crystal structure is determined, and mechanical properties are measured. The calculated values of the elastic constants, hardness, and fracture toughness of the new material agree with the experimental findings. A comprehensive theoretical investigation makes...

1w

Chirally Reversed Graphene Oxide Liquid Crystals

Graphene oxide liquid crystal (GOLC) fibers with hierarchical core‐skin architectures are successfully fabricated using an innovative synchronous nanofluidic rectification technique, in which the hydrogel skin formation and graphene oxide sheet assemblies are synchronous. The GOLC fibers possess a reversed cholesteric order and exhibit controllable...

1w

Self‐Assembling Glycopeptide Conjugate as a Versatile Platform for Mimicking Complex Polysaccharides

A glycopeptide‐based self‐assembly containing monosaccharides and phosphates is established to display simple carbohydrates in a multivalent format, mimicking natural complex polysaccharides. Among several evaluated glycoforms, the self‐assembled mannosylated nanoparticles exhibit immunostimulatory effects both in vitro and in vivo. Abstract...

1w