1 nm high metallic optical cavities of precise size and shape are self-assembled, which exhibit highly-consistent modes and greatly improve directional light emission, thereby enabling widespread application in optoelectronics through extreme light confinement. Abstract Bottom-up assembly of nanoparticle-on-mirror (NPoM) nanocavities enables...
11h
The first degrader of BMI1 and RING1B is achieved via a novel protein complex degrader strategy, which utilizes an EED small-molecule binder linked to a ligand of the E3 ligase von Hippel-Lindau to preferentially degrade PRC1 components, BMI1 and RING1B, over EED, by hijacking the ubiquitin-proteasome system. Abstract Polycomb repressive complex...
11h
Century-long evolution of microplastic deposition in cold seep sediment is investigated in detail. Microplastics in the non-seepage areas can reflect the historical usage of synthetic polymers, while that in the methane seepage locations are more likely to be carried into the water column, or fragmented and degraded in the sediment. Abstract...
11h
Photocatalytic technique is considered a promising energy conversion passway to alleviate energy crisis and environmental issues. Carbon dots as emerging photocatalysts or cocatalysts with outstanding physicochemical properties are widely applied in photocatalytic hydrogen generation, CO2 reduction, nitrogen fixation, pollutant degradation or organic...
11h
In the current study, a diacylation crosslinking strategy is developed to regulate CRISPR systems and DPPEA is used to restore the RNA structure to conditionally control gene editing when needed. Abstract Conditional control of RNA structure and function has emerged as an effective toolkit. Here, a strategy based on a one-step introduction of...
11h
In this study, a data storage system in Halomonas bluephagenesis genomes, which supports frequent and rapid data retrieval and automated data regeneration in non-professional environments, are developed. This system expands the application scenarios of DNA data storage to frequent “warm data” accessing in household and field settings, and also underscores...
11h
In this work, a general framework is presented for quantum interference between processes that can involve different fundamental particles or quasi-particles. Shaping input wavefunctions is revealed to be a versatile and powerful tool for producing and controlling quantum interference between distinguishable pathways, beyond previously explored quantum...
11h
Phosphorus-rich MnP, manganese-rich Mn2P, and their heterostructure MnP–Mn2P nanoparticles are accurately synthesized and their electrochemical properties and enhancement mechanisms are systematically investigated as sulfur hosts in LiS batteries. Abstract The targeted synthesis of manganese phosphides with target phase remains a huge challenge...
11h
This study provides novel insights into the origin of extracellularly detectable electrochemical signals of living cells. The proposed differential pulse voltammetry + metabolic activator cocktail (DPV+MAC) method, which activates key metabolic reactions in living cells, is effectively applied for rapid drug screening and non-destructive detection of...
11h
Fasting is emerging as a simple but attractive strategy for fighting human diseases, including aging, cancer, neurodegenerative diseases, and metabolic disorders. This review provides an a timely overview of the role and mechanism of fasting in physiology and pathology, highlights the therapeutic potential of fasting, alone and in combination with pharmacological...
11h
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