Digital CRISPR/Cas‐Assisted Assay for Rapid and Sensitive Detection of SARS‐CoV‐2

A digital clustered regularly interspaced short palindromic repeats (CRISPR)/Cas‐assisted nucleic acid detection assay is created by discretizing a one‐step, fluorescence‐based, CRISPR/Cas12a‐assisted reverse transcription recombinase polymerase amplification assay within sub‐nanoliter reaction wells of a commercial microfluidic digital chip, which...

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A Micromachined Picocalorimeter Sensor for Liquid Samples with Application to Chemical Reactions and Biochemistry

A highly sensitive chip calorimetric sensor that is capable of resolving picowatt‐level heat dissipation using low‐noise thermopiles is developed. Four references are used to eliminate any effect of ambient temperature changes; a hydrogel‐lined enclosure minimizes sample evaporation without impact on the thermal mass of the sensor. The sensor is demonstrated...

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Tackling Photonic Inverse Design with Machine Learning

Employing engineered photonic structures for unconventional control of light represents a central theme in modern optics. The last few years have witnessed a growing trend of exploring artificial intelligence for the design of photonic materials and devices. Herein, the fast advances of machine‐learning‐enabled photonic design strategies are summarized,...

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Lithium‐Metal Electrodes: Efficient Lithium Growth Control from Ordered Nitrogen‐Chelated Lithium‐Ion for High Performance Lithium Metal Batteries (Adv. Sci. 1/2021)

In article number 2002144, Hyung Mo Jeong and co‐worker suggest an effective 3D lithium (Li) guiding matrix using metal‐organic frameworks comprising a bipyridine linker for high‐performance Li metal batteries. Chelated Li‐ion (Li+) on ordered lithiophilic bipyridine sites induce the uniform Li+ flux on electrodes, leading to isotropic Li growth. The...

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Skin‐Inspired Piezoelectric Tactile Sensor Array with Crosstalk‐Free Row+Column Electrodes for Spatiotemporally Distinguishing Diverse Stimuli

Human skin‐inspired piezoelectric tactile sensor array can sense and distinguish the magnitude, positions, and modes of diverse external stimuli in real time. The dual‐layer comb structures of the sensor array with row+column electrodes eliminate crosstalk and reduce the number of connection wires. It excavates enormous applications in various settings,...

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Facile Fabrication of Self‐Assembly Functionalized Polythiophene Hole Transporting Layer for High Performance Perovskite Solar Cells

Self‐assembled P3HT‐COOH is an excellent hole extraction layer to fabricate robust, high‐performance, and extremely reproducible perovskite solar cells. The well‐aligned self‐assembled P3HT‐COOH generates a dipole layer between indium tin oxide and perovskite, substantially retarding interface charge recombination and producing highly sensitive devices...

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TAK1 Phosphorylates RASSF9 and Inhibits Esophageal Squamous Tumor Cell Proliferation by Targeting the RAS/MEK/ERK Axis

TAK1 is decreased in esophageal squamous tumor cells, RASSF9 binds to RAS and causes RAS dimerization, which triggers RAF/MEK/ERK signal transduction and tumor cell proliferation. In the presence of TAK1, it phosphorylates RASSF9 at Serine284 and this modification disrupts RAS dimerization, leading to a blockade of downstream pathway and cell proliferation....

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Ultrasensitive Point‐of‐Care Test for Tumor Marker in Human Saliva Based on Luminescence‐Amplification Strategy of Lanthanide Nanoprobes

The point‐of‐care detection of tumor markers in saliva is realized based on luminescence‐amplification strategy of lanthanide nanoprobes with disposable syringe filter as bioassay platform. The proposed strategy can be carried out within 10 min, exhibiting a detection limit down to 1.47 pg mL−1 for carcinoembryonic antigen, which shows the great promise...

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Surface‐Anchored Nanogel Coating Endows Stem Cells with Stress Resistance and Reparative Potency via Turning Down the Cytokine‐Receptor Binding Pathways

The cell surface masking of a nanogel endows individual cells with enhanced stress resistance and serves as a protective barrier to protect stem cells from apoptosis by reducing the binding between cytokines and their receptors, and improving the reparative potency of transplanted cells through paracrine effects in infarcted hearts, which will aid the...

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Insight into the Critical Role of Exchange Current Density on Electrodeposition Behavior of Lithium Metal

The effect of exchange current density on electrodeposition behavior of lithium (Li) is revealed by a phase‐field modeling and validated by experimental data. The results show that lower exchange current density contributes to uniform distribution of cathodic current density and formation of nuclei with larger critical radius, two factors that promote...

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