Advanced Science

Wiley Online Library : Advanced Science

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Artificial Organelles with Orthogonal‐Responsive Membranes for Protocell Systems: Probing the Intrinsic and Sequential Docking and Diffusion of Cargo into Two Coexisting Avidin–Polymersomes

For studying orthogonal‐responsive membranes in eukaryotic protocells, artificial organelles are constructed by two different pH‐stable and pH‐responsive avidin–polymersome biohybrid structures. Different pH‐dependent “open”, “closing/opening”, and “closed” membrane states of the two coexisting biohybrid structures pave the way to different intrinsic...

Combination Cancer Immunotherapy: Immunogenic Cell Death Inducing Fluorinated Mitochondria‐Disrupting Helical Polypeptide Synergizes with PD‐L1 Immune Checkpoint Blockade (Adv. Sci. 7/2021)

In article number 2001308, Chae‐Ok Yun, Yeu‐Chun Kim, and co‐workers develop endoplasmic reticulum (ER) stress‐mediated immunogenic cell death (ICD) inducing fluorinated mitochondria‐disrupting helical polypeptides (MDHPs). These helical polypeptides destabilize the mitochondrial outer membrane, leading to the overproduction of intracellular reactive...

Myocardial Viability Imaging using Manganese‐Enhanced MRI in the First Hours after Myocardial Infarction

Early measurements of tissue viability after myocardial infarction (MI) are essential for accurate diagnosis and treatment planning. Here, the safety and efficacy of manganese‐enhanced magnetic resonance imaging (MEMRI) in vitro in cardiomyocytes and in vivo in mouse models of MI are evaluated. It is demonstrated that MEMRI offers a novel biomarker...

Terahertz Driven Reversible Topological Phase Transition of Monolayer Transition Metal Dichalcogenides

Optomechanical theory is developed to predict how terahertz optics can drive ultrafast and reversible topological phase transitions in transition metal dichalcogenide monolayers, which is a non‐contacting approach that can work on free‐standing membranes. Density functional theory calculations are performed to evaluate the optical response functions...

High‐Throughput Discovery of Ni(IN)2 for Ethane/Ethylene Separation

High‐throughput computational screening is performed to discover C2H6‐selective metal–organic frameworks (MOFs) in the Computation‐Ready, Experimental (CoRE) MOF 2019 database. With a well‐matched pore environment, Ni(IN)2 can selectively adsorb C2H6 over C2H4 with a high experimental C2H6/C2H4 selectivity of 2.45. Abstract Although ethylene...

Targeted Drug Delivery for Sustainable Crop Protection: Transport and Stability of Polymeric Nanocarriers in Plants

Nanocarrier‐mediated release of agrochemicals in planta is a promising approach to treat plant diseases and to reduce spraying of chemicals. This paper investigates the transport of a diverse library of polymeric nanocarriers in vitro and in planta rendering drug delivery in plants with nanocarriers a promising tool for future agriculture. Abstract...

A New PqsR Inverse Agonist Potentiates Tobramycin Efficacy to Eradicate Pseudomonas aeruginosa Biofilms

The discovery and profiling of a novel Pseudomonas aeruginosa‐targeting Quorum Sensing Inhibitor (QSI) with high anti‐virulence efficacy, favorable DMPK and no overt safety pharmacology is reported. The in vivo target engagement of the lead QSI in a mucoid lung‐infection mouse model is demonstrated. Importantly, the application of a state‐of‐the‐art...

An Artificial Polyacrylonitrile Coating Layer Confining Zinc Dendrite Growth for Highly Reversible Aqueous Zinc‐Based Batteries

A polyacrylonitrile (PAN)Z coating layer is employed to confine zinc dendrite growth for rechargeable aqueous zinc‐based batteries. The cyclability and Coulombic efficiency of the zinc anode porous PAN coating layer show that the polymer coating film is a feasible artificial membrane for a dendrite‐free zinc anode. Abstract Aqueous rechargeable...

2D WSe2 Flakes for Synergistic Modulation of Grain Growth and Charge Transfer in Tin‐Based Perovskite Solar Cells

Liquid‐exfoliated 2D transition‐metal dichalcogenides (MoS2, WS2, and WSe2) are introduced as growth templates for spin‐coated FASnI3 perovskite films, leading to van der Waals epitaxial growth of perovskite grains with a growth orientation along (100). The good energy alignment in the NiO x /WSe2/FASnI3 structure facilitates hole extraction and...

Adipocyte Fatty Acid Binding Protein Promotes the Onset and Progression of Liver Fibrosis via Mediating the Crosstalk between Liver Sinusoidal Endothelial Cells and Hepatic Stellate Cells

Chronic liver injury upregulates adipocyte fatty acid binding protein (A‐FABP) in liver sinusoidal endothelial cells (LSECs). A‐FABP potentiates LSEC capillarization through activating Hh signaling, thus initiating hepatic stellate cell (HSC) activation. Moreover, LSEC‐derived A‐FABP stimulates TGFβ1 expression in HSCs through activating JNK/c‐Jun signaling....

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