Hepatocyte Deletion of IGF2 Prevents DNA Damage and Tumor Formation in Hepatocellular Carcinoma

Deletion of insulin-like growth factor 2 (IGF2) prevents liver cancer in the serine-arginine rich splicing factor 3 (SRSF3) knockout mouse model by restoring DNA repair enzymes and preventing DNA damage. SRSF3 protein is reduced in human HCC samples and SRSF3-dependent splicing predicts survival. IGF2 overexpression and SRSF3 loss could thus be a major...

8h

Interventional Microbubble Enhanced Sonothrombolysis on Left Ventricular Assist Devices

An interventional sonothrombolysis (IST) method is developed to realize high efficient and safe thrombolysis on LVAD with integrated ultrasound units and thrombus-targeted drug-loaded microbubbles. It is verified by proof-of-concept experiments on sheep that the thrombus can be dissolved in 30 min without damage on LVADs and organs. This method has...

8h

ALTEN: A High‐Fidelity Primary Tissue‐Engineering Platform to Assess Cellular Responses Ex Vivo

Alginate-based tissue engineering (ALTEN) enables three-dimensional (3D) ex vivo culture of explanted tissue biopsies. This method recapitulates the original characteristics of the source tissue's cellular niches with high-fidelity, including cellular diversity, extracellular matrix (ECM), and their molecular milieu. ALTEN enables rapid and faithful...

8h

Rapid Profiling of Tumor‐Immune Interaction Using Acoustically Assembled Patient‐Derived Cell Clusters

Acoustically assembled patient-derived cell clusters for the rapid profiling of complicated tumor microenvironment crosstalk are reported. This method is demonstrated to successfully model interactions among cancer cells, T cells, and short-lived myeloid-derived suppressor cells within 24 h. This method holds promising potential in predicting treatment...

8h

Simple and Scalable Chemical Surface Patterning via Direct Deposition from Immobilized Plasma Filaments in a Dielectric Barrier Discharge

Sub-mm patterned thin films of plasma polymerized propargyl methacrylate are obtained using a dielectric barrier discharge device. Plasma filaments are immobilized by texturing one dielectric with beads and lead to faster deposition than the surrounding plasma phase. Wettability contrasts were observed and related to differences in the chemical composition...

1d

Progressive and Stable Synaptic Plasticity with Femtojoule Energy Consumption by the Interface Engineering of a Metal/Ferroelectric/Semiconductor

In this study, an energy-efficient synaptic device based on a Ni/Pb(Zr0.52Ti0.48)O3 (PZT)/Nb-doped SrTiO3 heterojunction with a low reading current and a short operation time that results from the interface engineering between top electrode and PZT is implemented. Furthermore, PZT ferroelectric with multi-domain configurations can enable electrical...

1d

Control of COVID‐19 Outbreaks under Stochastic Community Dynamics, Bimodality, or Limited Vaccination

The limits of control and the effect of measures against future COVID-19 outbreaks are identified using a detailed community-specific ABM. The demographic and geographic structure of assessed communities influence the pattern of infection spreading and the resulting R-values. Stochastic community dynamics and limited vaccination can lead to bimodal...

1d

Hot Carrier Transport and Carrier Multiplication Induced High Performance Vertical Graphene/Silicon Dynamic Diode Generator

The vertical graphene/silicon dynamic diode generator (DDG) is proposed and the detailed hot carrier dynamics are explored. High voltage of 6.1 V and current of 235.6 nA are achieved in monolayer graphene/silicon DDG unit, attributing to ultrafast carrier transport and carrier multiplication in graphene. This work provides a novel and potential in situ...

1d

Microbiota in Tumors: From Understanding to Application

Intratumor microbiota is a hot spot in tumor research. In recent years, remarkable progress has been achieved in functions and application potential of intratumor microbiota. This review summarizes source, mechanisms, heterogeneity, and research techniques of intratumor microbiota, and discusses their potential for clinical translation to provide new...

3d

Dimensionality‐Controlled Evolution of Charge‐Transfer Energy in Digital Nickelates Superlattices

A series of high-quality (NdNiO3) m /(SrTiO3)1 superlattices are grown to systematically investigate the electronic structure evolution under dimensional confinement through transport and soft X-ray absorption spectroscopy. The charge-transfer energy between O 2p and Ni 3d increases significantly with the thickness of NdNiO3 slab reducing, resulting...

3d