Advanced Science

Wiley Online Library : Advanced Science

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Nanoarchitectonics for Wide Bandgap Semiconductor Nanowires: Toward the Next Generation of Nanoelectromechanical Systems for Environmental Monitoring

Wide bandgap semiconductor nanowires with unique properties and advanced fabrication/integration technologies set a new class of nanosensing and electronic applications. Implementation of these smart devices such as gas sensors, photodetectors, wearable devices, strain sensors, and energy harvesters into environmental monitoring systems offers promising...

Dual‐Strategy of Cation‐Doping and Nanoengineering Enables Fast and Stable Sodium‐Ion Storage in a Novel Fe/Mn‐Based Layered Oxide Cathode

Pearl necklace‐like hierarchical nanostructures of a P2‐Na0.76Cu0.22Fe0.30Mn0.48O2 cathode are synthesized by electrospinning and evaluated in sodium‐ion batteries. The synergistic effects of Cu doping and nanoengineering enable high Na+ coefficients and low ionic migration energy barrier, as well as highly reversible structure evolution and Cu/Fe/Mn...

CD63+ Cancer‐Associated Fibroblasts Confer Tamoxifen Resistance to Breast Cancer Cells through Exosomal miR‐22

Tamoxifen resistance is a severe clinical challenge in breast cancer treatment. In the present study, single‐cell RNA sequencing reveals a new subset of cancer‐associated fibroblast (CD63+ CAF) in the tumor microenvironment, which downregulates ERα and PTEN expression in breast cancer cells through exosomal miR‐22 and thus induces tamoxifen resistance....

Multiscale Characterization of Embryonic Long Bone Mineralization in Mice

Long bones are largely formed through endochondral ossification, where a cartilage template gradually mineralizes into a bone‐like tissue. However, the characteristics of this mineralization process at the smaller length scales remain unclear. Using a range of high‐resolution synchrotron‐based techniques, distribution of molecular and elemental content,...

Predicting the Outbreak Risks and Inflection Points of COVID‐19 Pandemic with Classic Ecological Theories

Predicting the outbreak risks and/or the inflection (turning or tipping) points of newly emerging infectious diseases such as COVID‐19 can be rather challenging. Here, the challenge is addressed by modeling and simulation approaches guided by classic ecological theories and by treating the COVID‐19 pandemic as a spatiotemporal dynamics problem on the...

An Alkaline Based Method for Generating Crystalline, Strong, and Shape Memory Polyvinyl Alcohol Biomaterials

This work introduces a facile strategy to induce crystallinity and produce physically crosslinked polyvinyl alcohol biomaterials with high mechanical properties, stable chemistry, resistance to injury, and shape memory properties. Fabrication methods for producing hydrogel‐based catheters, injectable electronics and microfluidic devices are discussed,...

Controllable and Diversiform Topological Morphologies of Self‐Assembling Supra‐Amphiphiles with Aggregation‐Induced Emission Characteristics for Mimicking Light‐Harvesting Antenna

Diversiform topological morphologies including leaf‐like lamella, nanoribbons, vesicles, nanofibers, helical nanofibers, and toroids are straightforwardly realized through supramolecular self‐assembly of a novel aggregation‐induced emission (AIE)‐active supra‐amphiphile under different solvent proportioning and/or temperature. The fabricated supramolecular...

EGF Relays Signals to COP1 and Facilitates FOXO4 Degradation to Promote Tumorigenesis

Forkhead‐Box Class O 4 (FOXO4) levels are downregulated in response to epidermal growth factor (EGF) treatment, with concurrent elevation of COP9 signalosome subunit 6 (CSN6) and E3 ubiquitin ligase constitutive photomorphogenic 1 levels. EGF‐mediated downregulation of FOXO4 rewires cancer metabolic programming via enhancing the expression of serine‐glycine‐one‐carbon...

MeCas12a, a Highly Sensitive and Specific System for COVID‐19 Detection

A Manganese‐enhanced Cas12a‐based (MeCas12a) system is developed, enabling the limit of detection to reach five copies and high specificity. The MeCas12a can detect severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) well in clinical samples, and distinguish synthetic SARS‐CoV‐2 and Middle East respiratory syndrome coronavirus (MERS‐CoV) RNAs,...

Oxidation of Arsenite by Epoxy Group on Reduced Graphene Oxide/Metal Oxide Composite Materials

Oxidation of adsorbed arsenite (As(III)) on reduced graphene oxide/metal oxide (rGO/MO) occurs in the absence of other oxidants or radicals. Reduced graphene oxide (rGO) acts as an oxidant rather than a catalyst for As(III) oxidation, while metal oxide provides sites for As(III) adsorption. During the adsorption–oxidation process, the epoxy group on...

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