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Full Control of Plasmonic Nanocavities Using Gold Decahedra‐on‐Mirror Constructs with Monodisperse Facets

1 nm high metallic optical cavities of precise size and shape are self-assembled, which exhibit highly-consistent modes and greatly improve directional light emission, thereby enabling widespread application in optoelectronics through extreme light confinement. Abstract Bottom-up assembly of nanoparticle-on-mirror (NPoM) nanocavities enables...

Targeted Degradation of PRC1 Components, BMI1 and RING1B, via a Novel Protein Complex Degrader Strategy

The first degrader of BMI1 and RING1B is achieved via a novel protein complex degrader strategy, which utilizes an EED small-molecule binder linked to a ligand of the E3 ligase von Hippel-Lindau to preferentially degrade PRC1 components, BMI1 and RING1B, over EED, by hijacking the ubiquitin-proteasome system. Abstract Polycomb repressive complex...

Tracing the Century‐Long Evolution of Microplastics Deposition in a Cold Seep

Century-long evolution of microplastic deposition in cold seep sediment is investigated in detail. Microplastics in the non-seepage areas can reflect the historical usage of synthetic polymers, while that in the methane seepage locations are more likely to be carried into the water column, or fragmented and degraded in the sediment. Abstract...

Carbon Dots Based Photoinduced Reactions: Advances and Perspective

Photocatalytic technique is considered a promising energy conversion passway to alleviate energy crisis and environmental issues. Carbon dots as emerging photocatalysts or cocatalysts with outstanding physicochemical properties are widely applied in photocatalytic hydrogen generation, CO2 reduction, nitrogen fixation, pollutant degradation or organic...

Chemical Control of CRISPR Gene Editing via Conditional Diacylation Crosslinking of Guide RNAs

In the current study, a diacylation crosslinking strategy is developed to regulate CRISPR systems and DPPEA is used to restore the RNA structure to conditionally control gene editing when needed. Abstract Conditional control of RNA structure and function has emerged as an effective toolkit. Here, a strategy based on a one-step introduction of...

Mobile and Self‐Sustained Data Storage in an Extremophile Genomic DNA

In this study, a data storage system in Halomonas bluephagenesis genomes, which supports frequent and rapid data retrieval and automated data regeneration in non-professional environments, are developed. This system expands the application scenarios of DNA data storage to frequent “warm data” accessing in household and field settings, and also underscores...

Quantum Interference between Fundamentally Different Processes Is Enabled by Shaped Input Wavefunctions

In this work, a general framework is presented for quantum interference between processes that can involve different fundamental particles or quasi-particles. Shaping input wavefunctions is revealed to be a versatile and powerful tool for producing and controlling quantum interference between distinguishable pathways, beyond previously explored quantum...

Li–S Chemistry of Manganese Phosphides Nanoparticles With Optimized Phase

Phosphorus-rich MnP, manganese-rich Mn2P, and their heterostructure MnP–Mn2P nanoparticles are accurately synthesized and their electrochemical properties and enhancement mechanisms are systematically investigated as sulfur hosts in LiS batteries. Abstract The targeted synthesis of manganese phosphides with target phase remains a huge challenge...

Extracellularly Detectable Electrochemical Signals of Living Cells Originate from Metabolic Reactions

This study provides novel insights into the origin of extracellularly detectable electrochemical signals of living cells. The proposed differential pulse voltammetry + metabolic activator cocktail (DPV+MAC) method, which activates key metabolic reactions in living cells, is effectively applied for rapid drug screening and non-destructive detection of...

Fasting: From Physiology to Pathology

Fasting is emerging as a simple but attractive strategy for fighting human diseases, including aging, cancer, neurodegenerative diseases, and metabolic disorders. This review provides an a timely overview of the role and mechanism of fasting in physiology and pathology, highlights the therapeutic potential of fasting, alone and in combination with pharmacological...

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