Schwann cells exist in the peri-bronchiole and visceral pleura in the normal lung. Upon stimulation from cancer cells, Schwann cells acquire DCX positivity and sympathetic neuron-like properties via the activation of YAP/TAZ signaling. Cancer-associated Schwann cells (CAS) express catecholamine-synthesizing enzymes and synthesize adrenaline, which...

The combination therapy improved the treatment efficacy by increasing programmed cell death ligand-1 (PD-L1) expression leading to more efficient cell killing by anti-PD-L1 antibody photoimmunotherapy (αPD-L1-PIT). Furthermore, the PEGylated interferon-gamma (IFNγ) led to a CD8+ T cell-dominant tumor microenvironment (TME) with an enhanced anticancer...

Our study has revealed the increased expression of ZKSCAN3 in several PaCa cell lines. Furthermore, it has demonstrated that controlling ZKSCAN3 expression can regulate the progression of PaCa through autophagy. Therefore, the regulation of autophagy via ZKSCAN3 suggests a potential novel therapeutic target for PaCa. Abstract Elevated autophagy...

The heatmap of the top 1000 variable genes indicates the significance of RNA methylation in transcripts. We highlight high N6-methyladenosine in TCEAL8 as a novel marker for pancreatic cancer. Abstract N6-methyladenosine (m6A) is an RNA modification involved in RNA processing and widely found in transcripts. In cancer cells, m6A is upregulated,...

Microwave ablation plus α programmed death ligand 1 therapy may mediate the polarization of tumor-associated macrophages (TAM1s) in the tumor microenvironment, thereby slowing down tumor growth, which are at least partially related to the nuclear factor-κB/JAK-STAT1 signaling pathway. Furthermore, blocking the γ-interferon-Cxcl9-CD8+ T axis promoted...

In this study, we found that L-type amino acid transporter 1 (LAT1), an L-type amino acid transporter, is highly expressed in prostate cancer, especially in castration-resistant prostate cancer (CRPC). We also found that inhibition of LAT1 function by JPH203 reduced the proliferation of CRPC cells in vitro and in vivo. Furthermore, the novelty of...