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British Journal of Dermatology

Wiley Online Library : British Journal of Dermatology

Latest articles

Secukinumab shows high and sustained efficacy in nail psoriasis: 2.5‐year results from the randomized placebo‐controlled TRANSFIGURE study

Summary Background Secukinumab, a fully human monoclonal antibody that selectively neutralises interleukin‐17A, a cornerstone cytokine in psoriasis, has shown long‐lasting efficacy and safety in the complete spectrum of psoriasis manifestations. Objective To report the long‐term (2.5‐year) efficacy and safety of secukinumab in nail psoriasis....

Bullous skin disease patients in a high‐epidemic COVID‐19 area, Bergamo, Italy

Abstract Bullous pemphigoid (BP) and pemphigus vulgaris (PV) are blistering disorders associated with barrier disruption, immune dysregulation and use of immunosuppressing systemic therapy. Patients with BP and PV have higher potential risk factors for infections secondary to skin alterations, comorbidity and chronic treatment with immunosuppressing...

First‐ and third‐ generation EGFR inhibitors mediate distinct phosphoprotein signalling networks: implications for adverse dermatologic reactions

Abstract Epidermal growth factor receptor (EGFR) inhibitors are used to treat several malignancies but notoriously exert dermatologic toxicities, reducing patient adherence. Despite targeting the same receptor, different EGFR inhibitors exhibit distinct toxicities. Up to 90% of patients on EGFR inhibitors present with a papulopustular rash, with varying...

miRNA analysis of Childhood Atopic Dermatitis reveals a role for miR‐451a

Abstract Background MicroRNAs (miRNAs), important regulators of gene expression, have been implicated in a variety of disorders. The expression pattern of miRNAs in pediatric atopic dermatitis (AD) has not been well studied. Objective We sought to investigate miRNA expression profiles in different blood compartments of infants with AD. ...

Cutaneous manifestations in patients with COVID‐19: A preliminary review of an emerging issue

Summary Background The infection caused by the recently identified SARS‐CoV‐2, called COronaVIrus Disease‐19 (COVID‐19), has rapidly spread throughout the world. With the exponential increase of patients worldwide, the clinical spectrum of COVID‐19 is being better defined and new symptoms are emerging. Numerous reports are documenting the occurrence...

Treatment of early‐stage mycosis fungoides: results from the PROspective Cutaneous Lymphoma International Study (PROCLIPI study)

Abstract Background The PROspective Cutaneous Lymphoma International Prognostic Index (PROCLIPI) Study is a prospective analysis of an international database and here we examine front‐line treatments and quality‐of‐life in patients with newly diagnosed Mycosis Fungoides (MF). Objectives a) differences in first‐line approach according to the...

Targeting fear of recurrence: The advantages of assessing psychosocial attributes and psychological dispositions

Abstract We found the randomized controlled trial of a brief psychological intervention targeting fear of recurrence of melanoma patients by Dieng et al. very interesting. The intervention has been shown to be effective and its implementation in the routine care of melanoma patients seems appropriate. In this regard we have developed some considerations...

The challenging management of a series of 43 infants with Netherton syndrome: unexpected complications and novel mutations

Summary Background Netherton syndrome (NS) is a rare disease caused by SPINK5 mutations, featuring variable skin and hair involvement and, in many cases, allergic manifestations with a risk of lethality particularly in infants. The clinical management is challenging. Objectives To analyse the clinical manifestations of a cohort of NS infants...

First real‐world data provide evidence for a ‘window of opportunity’ in treatment of hidradenitis suppurativa/acne inversa

Assessment of patient knowledge and completion of advance directives in oncodermatology

Abstract Advance directives (AD) are the possibility for any individual to express their wishes on how to be cared at the end of life, when they can no longer make the decisions themselves. In France, AD are only applicable during the end‐of‐life period, such as after an irrecoverable accident or at a terminal phase of a disease. It appeared for the...

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