Wiley Online Library : Cell Proliferation
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Pcolce2 overexpression promotes supporting cell reprogramming in the neonatal mouse cochlea

Our study found that AAV-Pcolce2 promoted the re-entry of SCs into the cell cycle in cultured cochlear organ tissues and in the postnatal cochlea, and regenerating HCs were detected in a neomycin injury model after overexpression of Pcolce2, which were derived from re-entering cell cycle SCs. Abstract Hair cell (HC) damage is a leading cause...

Tue Mar 26, 2024 12:17
Rack1‐mediated ferroptosis affects hindgut development in rats with anorectal malformations: Spatial transcriptome insights

Spatial transcriptome sequencing of normal and anorectal malformation (ARM) rat embryos revealed that Rack1, as a hub gene, was decreased in the ARM hindgut on GD15 and GD16, and increased intracellular ferrous ions, reactive oxygen species, and lipid peroxides through the P38/Nqo1/Gpx4 axis, inducing ferroptosis in intestinal epithelial cells, which...

Tue Mar 26, 2024 12:17
Cholestyramine alleviates bone and muscle loss in irritable bowel syndrome via regulating bile acid metabolism

This study reveals that irritable bowel syndrome (IBS) contributes to bone and muscle loss through microbial dysbiosis and increased bile acid (BA) levels. Notably, administering cholestyramine ameliorates these effects by decreasing BA contents and modulating gut microbiota, underscoring its therapeutic potential in managing IBS-induced musculoskeletal...

Tue Mar 26, 2024 12:17
Dendritic cell‐targeted delivery of antigens using extracellular vesicles for anti‐cancer immunotherapy

Red blood cell-derived extracellular vesicles (RBCEVs) are loaded with protein antigen and are surface-modified with DEC205-targeting antibodies. The antigen-loaded, DEC205-targeting RBCEVs are taken up by dendritic cells and antigens are processed. Via DEC205-mediated endocytosis, the antigens are digested and presented on MHC class I, which, in...

Thu Mar 21, 2024 11:36
Advances in the study of S100A9 in cardiovascular diseases

S100A9 is released by immune and tissue cells in response to stressors such as damage, inflammation, and oxidative stress. This leads to the amplification of inflammation, anti-inflammatory effects, induction of endothelial dysfunction, promotion of vascular microcalcification, as well as stimulation of cell proliferation, autophagy, apoptosis, and...

Wed Mar 20, 2024 11:09
Decoding human in vitro terminal erythropoiesis originating from umbilical cord blood mononuclear cells and pluripotent stem cells

scRNA-seq and cell typing of late-stage umbilical cord blood mononuclear cells- and pluripotent stem cell (PSC)-derived cells were conducted. Stress erythropoiesis was more active in UCBMN-derived erythropoiesis (UCB-E) than in PSC-derived erythropoiesis (PSC-E). Regulators that impair adult globin expression and enucleation between UCB-E and PSC-E...

Tue Mar 19, 2024 10:41

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