Cell Proliferation
Our study found that AAV-Pcolce2 promoted the re-entry of SCs into the cell cycle in cultured cochlear organ tissues and in the postnatal cochlea, and regenerating HCs were detected in a neomycin injury model after overexpression of Pcolce2, which were derived from re-entering cell cycle SCs. Abstract Hair cell (HC) damage is a leading cause...
Spatial transcriptome sequencing of normal and anorectal malformation (ARM) rat embryos revealed that Rack1, as a hub gene, was decreased in the ARM hindgut on GD15 and GD16, and increased intracellular ferrous ions, reactive oxygen species, and lipid peroxides through the P38/Nqo1/Gpx4 axis, inducing ferroptosis in intestinal epithelial cells, which...
This study reveals that irritable bowel syndrome (IBS) contributes to bone and muscle loss through microbial dysbiosis and increased bile acid (BA) levels. Notably, administering cholestyramine ameliorates these effects by decreasing BA contents and modulating gut microbiota, underscoring its therapeutic potential in managing IBS-induced musculoskeletal...
Red blood cell-derived extracellular vesicles (RBCEVs) are loaded with protein antigen and are surface-modified with DEC205-targeting antibodies. The antigen-loaded, DEC205-targeting RBCEVs are taken up by dendritic cells and antigens are processed. Via DEC205-mediated endocytosis, the antigens are digested and presented on MHC class I, which, in...
S100A9 is released by immune and tissue cells in response to stressors such as damage, inflammation, and oxidative stress. This leads to the amplification of inflammation, anti-inflammatory effects, induction of endothelial dysfunction, promotion of vascular microcalcification, as well as stimulation of cell proliferation, autophagy, apoptosis, and...
scRNA-seq and cell typing of late-stage umbilical cord blood mononuclear cells- and pluripotent stem cell (PSC)-derived cells were conducted. Stress erythropoiesis was more active in UCBMN-derived erythropoiesis (UCB-E) than in PSC-derived erythropoiesis (PSC-E). Regulators that impair adult globin expression and enucleation between UCB-E and PSC-E...
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