The Journal of Physiology, EarlyView.

Abstract figure legend Ionic mechanisms of ventricular fibrillation (VF) recurrence post-shock during cardiopulmonary resuscitation (CPR). Abstract Defibrillation remains the optimal therapy for terminating ventricular fibrillation (VF) in out-of-hospital cardiac arrest (OHCA) patients, with reported shock success rates of ∼90%. A key persistent...

Abstract figure legend Ischaemia is a major cause of lower urinary tract symptoms (LUTS), but ischaemic dysfunction is less prevalent in the urethra than in the bladder. In the bladder, sympathetic overdrive associated with ageing or metabolic syndrome would constrict arteries/arterioles resulting in blood flow reduction. In the urethra, parasympathetic...

The Journal of Physiology, EarlyView.

Abstract figure legend There are several lines of evidence from the rodent hippocampus that theta frequency oscillations (4–12 Hz) are rich in distal strata, while ripples (120–250 Hz) are prominent in strata that are within and around the pyramidal cell layer. Our goal here was to explore possible co-occurrence of these distinct bands of signals...

Abstract figure legend Mice expressing ChR2 in GABAergic neurons were trained in a difficult olfactory-discrimination (OD) task, resulting in acquisition of the ability to perform the task well, termed ‘rule learning’. Rats and mice become able to perform the task well. Following rule learning, metaplasticity of synaptic inhibition on piriform cortex...