Ma Huang-Ku Xing Ren, by targeting caspase-3, shows potential in effectively treating pediatric pneumonia by reducing apoptosis in alveolar macrophages, corroborated by network pharmacology, bioinformatics, and experimental data. Abstract This study investigates the molecular mechanism of Ma Huang-Ku Xing Ren, a traditional Chinese medicine formula,...

Four novel diosmetin derivatives showed strong multifunctional anti-AD activities, especially 3 showed the strongest inhibitory activities on ChE and Aβ1-42 aggregations. Furthermore, 3 also showed good BBB permeability, in vivo ROS scavenging activity and low cytotoxicity, which indicated that 3 might be a promising lead compound for the development...

β-Carboline scaffold is a well-known moiety that is extensively utilized in the creation of several anticancer medications. Numerous β-carboline derivatives have been synthesized, exhibits cytotoxic action through various mechanisms to date; however none have been associated with any adverse effects. Abstract β-Carboline nucleus is therapeutically...

Chemical Biology &Drug Design, Volume 103, Issue 4, April 2024.

Chemical Biology &Drug Design, Volume 103, Issue 4, April 2024.

Discovery of a benzothiazole class with good potency and selectivity index against L. infantum; SAR against L. infantum involving chemical modifications at the benzothiazole and acyl fragments; ADME properties were assessed for the most active compounds. Abstract An early exploration of the benzothiazole class against two kinetoplastid parasites,...