ScienceDirect Publication: Neuropharmacology

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Peptidomic analysis of hippocampal tissue for explore leptin neuroprotective effect on the preterm ischemia-hypoxia brain damage model rats

Publication date: Available online 30 September 2019Source: NeuropharmacologyAuthor(s): Ercui Feng, Li JiangAbstractThe most common injury of preterm infants is periventricular leukomalacia (PVL) and to date there is still no safe and effective treatment. In our previous studies, leptin has been found to have neuroprotective effects on the preterm ischemia-hypoxia...

Multifaceted regulation of the system A transporter Slc38a2 suggests nanoscale regulation of amino acid metabolism and cellular signaling

Publication date: Available online 28 September 2019Source: NeuropharmacologyAuthor(s): Robin Johansen Menchini, Farrukh Abbas ChaudhryAbstractAmino acids are essential for cellular protein synthesis, growth, metabolism, signaling and in stress responses. Cell plasma membranes harbor specialized transporters accumulating amino acids to support a variety...

Muscimol injection into the substantia nigra but not globus pallidus affects prepulse inhibition and startle reflex.

Publication date: Available online 26 September 2019Source: NeuropharmacologyAuthor(s): Samanta Rodrigues, Tatiana Lima FerreiraAbstractBehavioral arrest is an essential feature of an animal’s survival. Acoustic startle reflex (ASR) is an involuntary whole-body contraction of the skeletal musculature to an unexpected auditory stimulus. This strong reaction...

Pharmacological mechanisms of alcohol analgesic-like properties in mouse models of acute and chronic pain

Publication date: 1 December 2019Source: Neuropharmacology, Volume 160Author(s): Bradley Neddenriep, Deniz Bagdas, Katherine M. Contreras, Joseph W. Ditre, Jennifer T. Wolstenholme, Michael F. Miles, M. Imad DamajAbstractAlcohol use and chronic pain are highly comorbid. Acute alcohol use typically produces an analgesic effect. However, chronic use can...

Pharmacoresistance – Epidemiology, Mechanisms, And Impact On Epilepsy Treatment

Publication date: Available online 24 September 2019Source: NeuropharmacologyAuthor(s): Mubeen Janmohamed, Martin J. Brodie, Patrick KwanAbstractUnderstanding the natural history of and factors associated with pharmacoresistant epilepsy provides the foundation for formulating mechanistic hypotheses that can be evaluated to drive the development of novel...

Flavonoids as positive allosteric modulators of α7 nicotinic receptors

Publication date: Available online 24 September 2019Source: NeuropharmacologyAuthor(s): Beatriz Elizabeth Nielsen, Isabel Bermudez, Cecilia BouzatABSTRACTThe use of positive allosteric modulators (PAM) of α7 nicotinic receptors is a promising therapy for neurodegenerative, inflammatory and cognitive disorders. Flavonoids are polyphenolic compounds showing...

The mechanisms of potentiation and inhibition of GABA<sub>A</sub> receptors by non-steroidal anti-inflammatory drugs, niflumic and mefenamic acids

Publication date: Available online 24 September 2019Source: NeuropharmacologyAuthor(s): Alexey V. Rossokhin, Irina N. Sharonova, Anton Dvorzhak, Julia V. Bukanova, Vladimir G. SkrebitskyAbstractFenamates mefanamic and niflumic acids (MFA and NFA) induced dual potentiating and inhibitory effects on GABA currents recorded in isolated cerebellar Purkinje...

Endocrine effects of the novel ghrelin receptor inverse agonist PF-5190457: Results from a placebo-controlled human laboratory alcohol co-administration study in heavy drinkers

Publication date: Available online 23 September 2019Source: NeuropharmacologyAuthor(s): Mary R. Lee, Mehdi Farokhnia, Enoch Cobbina, Anitha Saravanakumar, Xiaobai Li, Jillian T. Battista, Lisa A. Farinelli, Fatemeh Akhlaghi, Lorenzo LeggioAbstractBoth animal and human work suggests that the ghrelin system may be involved in the mechanisms that regulate...

Ciliary neurotrophic factor signaling in the rat orbitofrontal cortex ameliorates stress-induced deficits in reversal learning

Publication date: 1 December 2019Source: Neuropharmacology, Volume 160Author(s): Milena Girotti, Jeri D. Silva, Christina M. George, David A. MorilakAbstractDeficits in cognitive flexibility, i.e. the ability to modify behavior in response to changes in the environment, are present in several psychiatric disorders and are often refractory to treatment....

Selective agonists of the δ-opioid receptor, KNT-127 and SNC80, act differentially on extinction learning of contextual fear memory in mice

Publication date: Available online 22 September 2019Source: NeuropharmacologyAuthor(s): Daisuke Yamada, Shoko Yanagisawa, Kazumi Yoshizawa, Shinya Yanagita, Jun-Ichiro Oka, Hiroshi Nagase, Akiyoshi SaitohAbstractWe reported previously that KNT-127 and SNC80, selective agonists of the δ-opioid receptor (DOP), had potent anxiolytic-like effects in rodents....

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