Precise T cell recognition programs designed by transcriptionally linking multiple receptors

Living cells often identify their correct partner or target cells by integrating information from multiple receptors, achieving levels of recognition that are difficult to obtain with individual molecular interactions. In this study, we engineered a diverse library of multireceptor cell-cell recognition circuits by using synthetic Notch receptors to...

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Missing freshwater found off Hawai'i

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News at a glance

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Testing physics using the hydrogen atom

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Arecibo radio telescope to be decommissioned

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Two-photon frequency comb spectroscopy of atomic hydrogen

We have performed two-photon ultraviolet direct frequency comb spectroscopy on the 1S-3S transition in atomic hydrogen to illuminate the so-called proton radius puzzle and to demonstrate the potential of this method. The proton radius puzzle is a significant discrepancy between data obtained with muonic hydrogen and regular atomic hydrogen that could...

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Laser fusion reactor approaches 'burning plasma milestone

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Abl and Canoe/Afadin mediate mechanotransduction at tricellular junctions

Epithelial structure is generated by the dynamic reorganization of cells in response to mechanical forces. Adherens junctions transmit forces between cells, but how cells sense and respond to these forces in vivo is not well understood. We identify a mechanotransduction pathway involving the Abl tyrosine kinase and Canoe/Afadin that stabilizes cell...

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Study homes in on 'exceptional responders to cancer drugs

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Structure of a vaccine candidate

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