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Neutrophils self-limit swarming to contain bacterial growth in vivo

Neutrophils communicate with each other to form swarms in infected organs. Coordination of this population response is critical for the elimination of bacteria and fungi. Using transgenic mice, we found that neutrophils have evolved an intrinsic mechanism to self-limit swarming and avoid uncontrolled aggregation during inflammation. G protein–coupled...

Common genetic variation influencing human white matter microstructure

Brain regions communicate with each other through tracts of myelinated axons, commonly referred to as white matter. We identified common genetic variants influencing white matter microstructure using diffusion magnetic resonance imaging of 43,802 individuals. Genome-wide association analysis identified 109 associated loci, 30 of which were detected...

Echolocation in soft-furred tree mice

Echolocation is the use of reflected sound to sense features of the environment. Here, we show that soft-furred tree mice (Typhlomys) echolocate based on multiple independent lines of evidence. Behavioral experiments show that these mice can locate and avoid obstacles in darkness using hearing and ultrasonic pulses. The proximal portion of their stylohyal...

In case of death

NF-{kappa}B dynamics determine the stimulus specificity of epigenomic reprogramming in macrophages

The epigenome of macrophages can be reprogrammed by extracellular cues, but the extent to which different stimuli achieve this is unclear. Nuclear factor B (NF-B) is a transcription factor that is activated by all pathogen-associated stimuli and can reprogram the epigenome by activating latent enhancers. However, we show that NF-B does so only in response...

Who do we invent for? Patents by women focus more on womens health, but few women get to invent

Women engage in less commercial patenting and invention than do men, which may affect what is invented. Using text analysis of all U.S. biomedical patents filed from 1976 through 2010, we found that patents with all-female inventor teams are 35% more likely than all-male teams to focus on women’s health. This effect holds over decades and across research...

Transition to marine ice cliff instability controlled by ice thickness gradients and velocity

Portions of ice sheets grounded deep beneath sea level can disintegrate if tall ice cliffs at the ice-ocean boundary start to collapse under their own weight. This process, called marine ice cliff instability, could lead to catastrophic retreat of sections of West Antarctica on decadal-to-century time scales. Here we use a model that resolves flow and...

Viral vulnerability in hepatocytes

DNA researchers question Senate bill's security provisions

Capturing exotic magnetism

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