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Dysregulation of ILC3s unleashes progression and immunotherapy resistance in colon cancer

ILC3s are altered in the tumor microenvironment of humans with colorectal cancer, resembling those found in the inflamed intestine. In mice, ILC3s regulate adaptive immunity, shape the microbiota composition, and protect from tumor progression as well as colorectal cancer immunotherapy resistance.

Chromatin and gene-regulatory dynamics of the developing human cerebral cortex at single-cell resolution

A single-cell atlas of gene expression and chromatin accessibility of human developing cortex during mid-gestation reveals lineage-determining transcription factors for human corticogenesis and identifies prioritized mutations for autism spectrum disorder.

Emergence of an early SARS-CoV-2 epidemic in the United States

Genomic and epidemiological analyses provide a clearer picture of one of the earliest SARS-CoV-2 superspreader events in the United States in accelerating transmission, with a single introduction of the virus being responsible for most cases during this period.

Memory B cell repertoire for recognition of evolving SARS-CoV-2 spike

Unbiased charting of memory B cell receptor-encoded antibodies from COVID-19 convalescent subjects identifies seven major antibody competition groups recognizing epitopic regions with group assignment correlating with cross-CoV-reactivity breadth and neutralization potency. SARS-CoV-2 variants tend to escape antibodies from groups with the most potent...

Antigen dominance hierarchies shape TCF1+ progenitor CD8 T cell phenotypes in tumors

Analysis of antigen dominance hierarchy and dynamics in a lung cancer model highlights the opportunity of optimizing T cell responses against subdominant neoantigens for better checkpoint blockade response through vaccination that adjusts T cell progenitor subpopulations

The expanding amyloid family: Structure, stability, function, and pathogenesis

A wealth of recent amyloid structures begins to illuminate these puzzling protein conformations, shedding light on how and why different conformations contribute to cellular function or disease.

Selfish centromeres, selfless heterochromatin

Centromeres are specialized regions on chromosomes recruiting a set of proteins required for faithful chromosome segregation. Differences in centromere strength can potentially bias chromosome segregation toward one of the daughter cells during division. Kumon et al. propose a new model of evolutionary impact on the balance of centromere strength.

Innovation, conservation, and repurposing of gene function in root cell type development

(Cell 184, 3333–3348.e1–e19; June 10, 2021)

Designer AAV muscle up

Directed evolution of AAV capsids has been a successful strategy for generating bespoke serotypes to target gene therapies more specifically to the intended tissue. This has now been achieved for the largest organ, skeletal muscle, by selecting for an RGD containing integrin binding heptamer in a hypervariable region of the capsid of AAV9.

Proteogenomic characterization of pancreatic ductal adenocarcinoma

Comparative multiomic analyses of pancreatic ductal adenocarcinoma tumors with normal adjacent and pancreatic ductal tissues provide insight into genomic, proteomic, and immune dysregulation in driving disease.

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