Pandemic Preparedness: Developing Vaccines and Therapeutic Antibodies For COVID-19

Collaboration between academic, government, and private institutions can enable the development and sustenance of a pandemic preparedness platform that can be readily deployed upon need, as is the case with the COVID-19 pandemic.

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Targets of T Cell Responses to SARS-CoV-2 Coronavirus in Humans with COVID-19 Disease and Unexposed Individuals

An analysis of immune cell responses to SARS-CoV-2 from recovered patients identifies the regions of the virus that is targeted and also reveals cross-reactivity with other common circulating coronaviruses

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Host-Viral Infection Maps Reveal Signatures of Severe COVID-19 Patients

A computational framework that allows for the identification and characterization of virus-infected cells as well as bystander cell responses reveals how SARS-CoV-2 alters the immune responses of patients.

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Role of Microbiota-Derived Bile Acids in Enteric Infections

In this issue of Cell, Alavi et al. report that infection by Vibrio cholerae is blocked by gut microbiome-mediated hydrolysis of bile acids. Cholera therefore joins amebic dysentery and Clostridioides difficile colitis as enteric infections profoundly influenced by the microbiome’s impact on bile acid metabolism.

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SnapShot: Jak-STAT Signaling II

The JAK-STAT pathway is an evolutionarily conserved signal transduction paradigm, providing mechanisms for rapid receptor-to-nucleus communication and transcription control. Discoveries in this field provided insights into primary immunodeficiencies, inherited autoimmune and autoinflammatory diseases, and hematologic and oncologic disorders, giving...

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Cap-Snatching Leads to Novel Viral Proteins

Some negative-sense RNA viruses prime mRNA transcription using host 5′ cap sequences, usurping host translational machinery and evading antiviral surveillance. In this issue of Cell, Ho et al. identify an additional consequence of this viral strategy: the acquisition of upstream start codons from host-derived sequences and subsequent translation of...

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Mapping the Uncharted Territories of Human Brain Malignancies

Despite its success in multiple tumor types, immunotherapy remains poorly efficacious in brain malignancies. In this issue of Cell, Friebel et al. and Klemm et al. provide in-depth insights into the versatile nuances of immune cells in primary and metastatic brain tumors, granting the field with a rich framework to explore novel therapeutic avenues.

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Retraction Notice to: A Monoclonal Antibody that Targets a NaV1.7 Channel Voltage Sensor for Pain and Itch Relief

(Cell 157, 1393–1404; June 5, 2014)

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Molecular Transducers of Physical Activity Consortium (MoTrPAC): Mapping the Dynamic Responses to Exercise

The Molecular Transducers of Physical Activity Consortium aims to create a comprehensive, integrative multi-omic map of the effects of exercise across tissues in rodents and healthy people.

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An Engineered CRISPR-Cas9 Mouse Line for Simultaneous Readout of Lineage Histories and Gene Expression Profiles in Single Cells

(Cell 181, 1410–1422.e1–e27; June 11, 2020)

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