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Kathryn Anderson (1952–2020)

On November 30, 2020, we lost the brilliant, generous, and forward-thinking leader who founded and chaired the Developmental Biology Program at the Sloan Kettering Institute from 2002 to 2019. Kathryn Anderson was an extraordinary scientist who made landmark discoveries at every stage of her career (Figure 1). Her work transformed our understanding...

Phosphorylation-Mediated IFN-γR2 Membrane Translocation Is Required to Activate Macrophage Innate Response

(Cell 175, 1336–1351.e1–e17; November 15, 2018)

Precision genome editing heralds rapid de novo domestication for new crops

The de novo domestication has the potential to rapidly capitalize on desirable traits of wild plants. In this issue of Cell, Yu et al. report a route of de novo domestication of an allotetraploid rice, heralding the creation of a novel staple food crop to support global food security.

How to make a better T cell: in vivo CRISPR screens have some answers

Understanding what regulates CD8+ T cell responses is key to effectively harnessing these cells in human disease. In this issue of Cell, Huang et al. and Chen et al. use in vivo CRISPR screens to discover novel regulators of CD8+ T cell immunity to engineer a more efficacious response against cancer and infections.

A vicious cycle in atherosclerosis

Clonal hematopoiesis, defined as the presence of expanded somatic blood cell clones, is associated with about a doubling in the risk of coronary heart disease in humans. Heyde and colleagues now provide evidence that clonal hematopoiesis results largely from increased stem cell proliferation, which is, in turn, stimulated by atherosclerosis.

An expanded universe of cancer targets

Members of the Cancer Target Discovery and Development Network synthesize recent insights into the different classes and characteristics of cancer therapeutic vulnerabilities.

Tumor-Induced Generation of Splenic Erythroblast-like Ter-Cells Promotes Tumor Progression

(Cell 173, 634–648.e1–e12; April 19, 2018)

Bone resorption goes green

In this issue of Cell, McDonald et al. show that giant multinucleated, bone-resorbing osteoclasts dissolve into smaller cells, termed “osteopmorhs,” which re-form into osteoclasts at distal bone sites (McDonald et al., 2021). These findings overturn the long-standing premise that osteoclasts differentiate solely from hematopoietic precursors and undergo...

Enteric helminth coinfection enhances host susceptibility to neurotropic flaviviruses via a tuft cell-IL-4 receptor signaling axis

Desai et al. show that the tuft cell/IL-4Rα circuit in the intestine can have detrimental consequences in the context of helminth and viral coinfection. Flavivirus infection of enteric neurons, in the setting of a type 2 immune response due to helminths, IL-25, or IL-4 signaling, impairs intestinal integrity and compromises host CD8+ T cell responses...

Increased stem cell proliferation in atherosclerosis accelerates clonal hematopoiesis

Heyde et al. propose that clonal hematopoiesis can be a symptom rather than a cause of atherosclerosis, since this disease increases hematopoietic stem cell division, which results in accelerated somatic evolution.

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