Two-component spike nanoparticle vaccine protects macaques from SARS-CoV-2 infection

Brouwer et al. present preclinical evidence in support of a COVID-19 vaccine candidate, designed as a self-assembling two-component protein nanoparticle displaying multiple copies of the SARS-CoV-2 spike protein, which induces strong neutralizing antibody responses and protects from high-dose SARS-CoV-2 challenge.

15h

G3BPs tether the TSC complex to lysosomes and suppress mTORC1 signaling

Distinct from their contributions to stress granules, G3BPs regulate mTORC1 activity through spatial control of the TSC complex.

17h

Changes in genome architecture and transcriptional dynamics progress independently of sensory experience during post-natal brain development

Tan et al. show that during development, both the transcriptome and 3D genome are extensively transformed in the first post-natal month independent of sensory experience, suggesting that the 3D transformation is predetermined.

3d

Adult neural stem cell activation in mice is regulated by the day/night cycle and intracellular calcium dynamics

Darkness-induced melatonin signaling modulates the proliferative state of neural stem cells through the modulation of Ca2+ dynamics as evidenced by live imaging and optogenetically induced “quiescent-state”-like calcium patterns in freely behaving mice.

4d

p53 is a central regulator driving neurodegeneration caused by C9orf72 poly(PR)

C9orf72 mutations associated with ALS and FTD activate a specific transcriptional program that converges on p53 to drive neurodegeneration in multiple C9orf72 models.

4d

Cell-cycle-dependent EBNA1-DNA crosslinking promotes replication termination at oriP and viral episome maintenance

Cell-cycle-dependent recombinase-like activity of EBNA1 is required for replication termination and viral episome maintenance of oncogenic Epstein-Barr virus.

4d

Infection trains the host for microbiota-enhanced resistance to pathogens

Previous intestinal infection increases the gut microbiota’s resistance to subsequent infection by inhibiting the ability of pathogens to respire.

2w

Food allergy as a biological food quality control system

Food allergy may be a harmful manifestation of a normal food quality control mechanism.

2w

Spliceosome-targeted therapies trigger an antiviral immune response in triple-negative breast cancer

Spliceosome-targeted therapies generate intron-retained, double-stranded RNAs that activate downstream antiviral signaling and extrinsic apoptosis in breast cancer.

2w

A basophil-neuronal axis promotes itch

Wang et al. show atopic dermatitis-associated inflammation promotes a basophil-leukotriene neuroimmune axis to evoke acute itch flares.

2w