Immunity RSS feed. Immunity is a monthly journal which publishes research articles and reviews of general interest in the entire discipline of immunology. Immunity was founded in the belief that advances in molecular and cellular immunology have
Autoantibodies to self-DNA are a defining feature of systemic lupus erythematosus (SLE), yet the mechanisms of their development remain poorly understood. Soni et al. show that anti-DNA autoreactivity is driven by extrafollicular B cell differentiation into short-lived plasmablasts, which is facilitated by plasmacytoid dendritic cells, type I interferon,...
Ni et al. define the transcriptional landscape of tumor-infiltrating NK cells using single-cell RNA sequencing. They find that the transcription factor HIF-1α suppresses IL-18-driven NF-κB signaling and anti-tumor activity of tumor-infiltrating NK cells. Extended inhibition of HIF-1α in mouse or human NK cells unleashes potent NK cell effector function.
Caspase-8 mediates apoptosis and blocks necroptosis. Additionally, Tummers et al. describe two ways in which caspase-8 triggers inflammatory signaling in vivo. Caspase-8 mediates CD95-induced inflammation in complex with its adaptor FADD. Furthermore, caspase-8 mediates inflammasome activation independently of FADD in epithelial cells. Both processes...
The emergence of novel respiratory viruses such as SARS-CoV-2 results in rapid dissemination through virus-naive populations and an accumulation of critically ill patients in hospitals across the globe. In the absence of an effective vaccine or proven treatment, this accelerating threat to human health must be met with swift deployment of experimental...
Beltra et al. define a hierarchical developmental pathway for CD8+ T cell exhaustion, revealing four stages and multistep transcriptional and epigenetic dynamics underlying subset transitions and subset-associated biological changes.
The emergence and rapid global spread of SARS-CoV-2 mark the third such identification of a novel coronavirus capable of causing severe, potentially fatal disease in humans in the 21st century. As noted by Andersen et al. (Nature Medicine), the sequencing of proximal zoonotic ancestors to SARS-CoV-2 has aided in the identification of alleles that may...
The dichotomy between type 1 and 2 conventional DCs under steady-state conditions is well defined. Bosteels et al. demonstrate that, upon inflammation, cDC2s acquire a hybrid inf-cDC2 phenotype, sharing phenotype, gene expression, and function with cDC1s and monocyte-derived cells, to optimally boost CD4 and CD8 immunity via Fc receptors.
The coronavirus disease 2019 (COVID-19) pandemic, caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has affected millions of people worldwide, igniting an unprecedented effort from the scientific community to understand the biological underpinning of COVID19 pathophysiology. In this review, we summarize the current state of knowledge...
In blood samples from COVID-19 convalescent subjects, Ni et al. have detected SARS-CoV-2-specific humoral and cellular immunity. Most subjects display serum neutralizing activities, which correlate with the numbers of virus-specific T cells.
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