Front Line Genomics

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Single Cell ONLINE November webinar series

Nearly all of the body’s functions are based on cellular heterogeneity – from complex neurobiological functions, to the development of disease from an individual tumour cell – single cell technologies can give incredible insights into health and disease. Despite single cell analysis already playing a major role in biological research, challenges...

Breast Cancer Awareness Month: On Fridays we wear pink

October is Breast Cancer Awareness month and on Friday (23rd October) charities are encouraging individuals to wear pink to raise awareness and money for breast cancer research. When I think deeply about breast cancer, I get extremely emotional. Have I ever experienced it? No. Do I know someone who has? Yes. Breast cancer is the most common...

Transposon expression impacts neuronal function

Research at the University of Oxford has revealed that transposon expression within the brain is not random and is in fact impacted by surrounding genes. Transposons Whilst previously thought to be ‘junk,’ researchers soon realised that the non-coding portion of the genome possessed a range of different genetic elements with functional...

Myths and facts

Fake news and misinformation within medicine and healthcare is a serious problem. The advent and popularisation of social media has enabled the flow of misinformation on a global scale. The COVID-19 pandemic is a key example of how misinformation can be dangerous. Despite evidence highlighting hydroxychloroquine’s lack of safety and efficacy, the President...

Genomics week in brief: Week ending 17th October

Another week of interesting and ground-breaking research, all brought to you in one place. Top stories from the past week Researchers have identified shared gene signatures in the peripheral blood and placenta from preeclamptic pregnancies, maternal asthma, vitamin D insufficiency and excess body mass index. (Mirzakhani et al,...

TESLA unlocks a new generation of immunotherapy

The international neoantigen initiative Tumour Neoantigen Selection Alliance (TESLA) has identified key parameters for immunotherapy advancement. Neoantigens Somatic alterations are a key hallmark of cancer. Alterations result in the generation of mutated peptide fragments, also known as neoantigens. These peptides are presented...

An up-close view of HIV

Researchers have recreated the first steps of infection by HIV in a test tube, providing an up-close access to the virus. HIV HIV, also known as human immunodeficiency virus, is an enveloped virus with two copies of positive-sense single-stranded RNA. In order to infect host cells, HIV must reverse transcribe its single-stranded...

Cryptic exon in mice is essential for male sex determination

An international collaboration with The University of Queensland has found a hidden DNA fragment that is critical for male sex determination. Male sex determination The mammalian sex-determining region Y (Sry) is a gene located on the Y chromosome that induces male development. For several decades, researchers have believed that...

Non-Genetic Mechanisms of Therapeutic Resistance in Cancer

Therapeutic resistance has repeatedly proved itself to be an unconquerable barrier for curative cancer treatment. However, recent investigations have challenged the common belief that genetic evolution is the main cause of tumour resistance. A recent study, published by Nature, explores a range of non-genetic adaptive mechanisms which contribute to...

Potential drug targets for paediatric germ cell tumours

Researchers have performed a comprehensive genetic analysis and identified potential drug targets for paediatric germ cell tumours (GCTs). Germ cell tumours GCTs are relatively rare in paediatric patients. The incidence rates are 5.3 and 4.4 per million in girls and boys, respectively. Typically, GCTs exhibit a bimodal age distribution,...

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