CONCLUSIONS: Luteolin demonstrated considerable anticancer effect on HGSOC cells, reduced VRK1 expression, and activated the p53 signaling pathway, thereby inducing apoptosis and cell cycle arrest in G2/M and inhibiting cell proliferation. Furthermore, luteolin exhibited a synergistic effect with cisplatin both in vivo and in vitro. Thus, luteolin can...

CONCLUSIONS: Intraoperative FS of SLNs in high-grade EC patients has poor sensitivity. Since isolated para-aortic metastases are rare, para-aortic lymphadenectomy may be omitted in patients in which SLNs were successfully mapped to the pelvis.PMID:37075495 | DOI:10.1016/j.ygyno.2023.04.004 (Source: Gynecologic Oncology)

Gynecol Oncol. 2023 Apr 17:S0090-8258(23)00169-5. doi: 10.1016/j.ygyno.2023.03.022. Online ahead of print.NO ABSTRACTPMID:37076336 | DOI:10.1016/j.ygyno.2023.03.022 (Source: Gynecologic Oncology)

CONCLUSION: The pooled proportion of lymphocele was 14% of which symptomatic lymphoceles occurred in 3%. Significant risk factors for the total proportion of lymphoceles were laparotomic approach, decreased number of lymph nodes dissected and additional PAOLND.PMID:36738486 | DOI:10.1016/j.ygyno.2023.01.022 (Source: Gynecologic Oncology)

CONCLUSIONS: Eribulin shows modest activity in patients with recurrent/advanced cervical cancer with a favorable toxicity profile. Prior paclitaxel exposure is associated with decreased eribulin response. βII, βIII tubulin subtypes and BAX are predictors of response and survival. Eribulin may be an option for women with paclitaxel-naïve recurrent/advanced...

CONCLUSION: Omission of PaLN dissection, in the absence of suspicious nodes, did not decrease survival. There were no isolated PaLN recurrences after PLND alone.PMID:36738482 | DOI:10.1016/j.ygyno.2023.01.031 (Source: Gynecologic Oncology)