Nature Chemistry

Nature Chemistry is a unique forum for chemists of all disciplines. Every month Nature Chemistry publishes original top-quality research, plus a compelling mix of news and reviews, in print and online.

Latest articles

Quantum machine learning using atom-in-molecule-based fragments selected on the fly

Nature Chemistry, Published online: 14 September 2020; doi:10.1038/s41557-020-0527-zQuantum machine learning with improved data efficiency and transferability has been achieved using on-the-fly selection of query-dependent training molecules, which are drawn from a ‘dictionary’ of atom-in-molecule-based fragments. The benefits of the resulting models...

One-pot, room-temperature conversion of dinitrogen to ammonium chloride at a main-group element

Nature Chemistry, Published online: 14 September 2020; doi:10.1038/s41557-020-0520-6The vast majority of species capable of converting dinitrogen to ammonia rely on transition metals. Now, a boron compound has been shown to mediate the one-pot binding, cleavage and reduction of N2 to ammonium salts under mild conditions through a complex cascade mechanism...

Lysine acylation using conjugating enzymes for site-specific modification and ubiquitination of recombinant proteins

Nature Chemistry, Published online: 14 September 2020; doi:10.1038/s41557-020-0528-yA chemoenzymatic method to site-specifically conjugate peptide and protein thioesters to folded proteins at lysine residues has been developed. The method uses a genetically encoded four-residue tag that is recognized by the E2 SUMO-conjugating enzyme Ubc9. This approach...

Meta-DNA structures

Nature Chemistry, Published online: 07 September 2020; doi:10.1038/s41557-020-0539-8A six-helix bundle DNA structure called meta-DNA has now been assembled and shown to possess some structural properties similar to those of single-stranded DNA. Two meta-DNAs containing complementary ‘meta-base pairs’ are shown to form double helices. Meta-DNA building...

Using sulfuramidimidoyl fluorides that undergo sulfur(<span class="small-caps">vi</span>) fluoride exchange for inverse drug discovery

Nature Chemistry, Published online: 31 August 2020; doi:10.1038/s41557-020-0530-4Latent functional groups—typically unreactive unless activated by protein binding—can provide additional selectivity to covalent drugs. Now, compounds containing the weakly electrophilic sulfuramidimidoyl fluoride group, capable of undergoing sulfur(vi) fluoride exchange,...

Atomic mechanism of metal crystal nucleus formation in a single-walled carbon nanotube

Nature Chemistry, Published online: 28 August 2020; doi:10.1038/s41557-020-0538-9Crystal nucleation processes are difficult to probe experimentally because of the spatial and temporal scales involved. Now, the heterogeneous nucleation of three different metals has been observed by electron microscopy with atomic resolution—using single-walled carbon...

The complex chemical effects of COVID-19 shutdowns on air quality

Nature Chemistry, Published online: 25 August 2020; doi:10.1038/s41557-020-0535-zStay-at-home policies invoked in response to COVID-19 have led to well-publicized drops in some air pollutants. The extent to which such reductions translate to improved air quality is dictated by not only emissions and meteorology, but also chemical transformations in...

Practical science at home in a pandemic world

Nature Chemistry, Published online: 25 August 2020; doi:10.1038/s41557-020-0543-zThere are plenty of online resources to ensure that learning can continue for students who cannot access universities during a pandemic, but what options are there for practical aspects of science courses? Daren J. Caruana, Christoph G. Salzmann and Andrea Sella offer a...

Ribosomal synthesis and de novo discovery of bioactive foldamer peptides containing cyclic β-amino acids

Nature Chemistry, Published online: 24 August 2020; doi:10.1038/s41557-020-0525-1Cyclic β-amino acids can add useful properties to peptides, such as inducing turn structures or providing resistance to proteases. To harness these properties up to ten consecutive cyclic β-amino acids have now been ribosomally incorporated via genetic code reprogramming...

A sound approach to self-assembly

Nature Chemistry, Published online: 24 August 2020; doi:10.1038/s41557-020-0526-0Controlling the formation of ordered and predictable patterns in dissipative reaction–diffusion processes is challenging. Now, liquid vibrations induced by audible sound have been shown to direct the formation of spatiotemporal patterns in switchable chemical systems and...

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