Nature Chemistry

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Barcoded DNA origami structures for multiplexed optimization and enrichment of DNA-based protein-binding cavities

Nature Chemistry, Published online: 13 July 2020; doi:10.1038/s41557-020-0504-6Multivalent binding is a common strategy to enhance the interactions between weak binding partners. Now, following this principle, DNA origami scaffolds have been used to arrange DNA aptamers into specific geometries and to optimize linker spacings and flexibilities, which...

Harder, better, faster

Nature Chemistry, Published online: 10 July 2020; doi:10.1038/s41557-020-0510-8The gap between fundamental academic research and the applied industrial research that is necessary to ensure real-world applications can be bridged by engaging in well-defined collaborative academia–industry projects and fostering better communication between the scientists...

Identification of targets of AMPylating Fic enzymes by co-substrate-mediated covalent capture

Nature Chemistry, Published online: 06 July 2020; doi:10.1038/s41557-020-0484-6Many bacterial pathogens release effector enzymes belonging to the large Fic family, which modify host targets with nucleotide monophosphates. Now, recombinantly produced Fic enzymes have been equipped with synthetic thiol-reactive nucleotide derivatives to make covalent...

Structural snapshots of the minimal PKS system responsible for octaketide biosynthesis

Nature Chemistry, Published online: 06 July 2020; doi:10.1038/s41557-020-0491-7The invariable core of a type II polyketide synthase has been characterized using X-ray crystallography, simulations, mutagenesis experiments and functional assays. The characterization of the ternary acyl carrier protein complexes provides a mechanistic understanding of...

Tunable exciton binding energy in 2D hybrid layered perovskites through donor–acceptor interactions within the organic layer

Nature Chemistry, Published online: 06 July 2020; doi:10.1038/s41557-020-0488-2The strength of electrostatic interactions in semiconductors strongly affects their performance in optoelectronic devices. Now, doping two-dimensional naphthalene-based lead halide perovskites with tetrachloro-1,2-benzoquinone has been shown to introduce donor–acceptor interactions...

Fast motion of molecular rotors in metal–organic framework struts at very low temperatures

Nature Chemistry, Published online: 06 July 2020; doi:10.1038/s41557-020-0495-3Molecular rotors have been engineered within the bicyclopentane–dicarboxylate struts of a metal–organic framework—the bicyclic unit is the rotator and the carboxylate groups serve as the stator. In a zinc-based metal–organic framework, the crossed conformation of the strut–metal...

Synthesis of a <i>d</i><sup>1</sup>-titanium fluoride kagome lattice antiferromagnet

Nature Chemistry, Published online: 29 June 2020; doi:10.1038/s41557-020-0490-8The highly frustrated spin-1/2 kagome lattice antiferromagnet, predicted to exhibit unconventional magnetic behaviours, has remained difficult to synthesize without structural imperfections. Now, a d1-titanium fluoride kagome lattice antiferromagnet has been prepared in which...

Time-dependent enantiodivergent synthesis via sequential kinetic resolution

Nature Chemistry, Published online: 29 June 2020; doi:10.1038/s41557-020-0489-1Access to both enantiomers of a chiral target compound typically relies on reversing the absolute configuration of the chiral component in the reaction system that is used to make them. A time-dependent enantiodivergent synthesis is reported in which the same enantiomer of...

Dual electrocatalysis enables enantioselective hydrocyanation of conjugated alkenes

Nature Chemistry, Published online: 29 June 2020; doi:10.1038/s41557-020-0469-5A general method for the enantioselective hydrocyanation of alkenes has been a long-standing synthetic challenge. Now, using a dual electrocatalytic approach that combines two synergistic redox catalytic cycles, a wide variety of chiral nitriles can be synthesized from conjugated...

NH<sub>3</sub> formation from N<sub>2</sub> and H<sub>2</sub> mediated by molecular tri-iron complexes

Nature Chemistry, Published online: 29 June 2020; doi:10.1038/s41557-020-0483-7The reduction of N2 to NH3 is mediated in living systems by the enzyme nitrogenase and in the chemical industry by the Haber–Bosch process; both systems rely on iron-based catalysis. Now, a molecular tri(iron)bis(nitrido) complex, prepared by reduction of a bis(iron)bis(iodo)...

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