Nature Chemistry is a unique forum for chemists of all disciplines. Every month Nature Chemistry publishes original top-quality research, plus a compelling mix of news and reviews, in print and online.
Nature Chemistry, Published online: 18 January 2021; doi:10.1038/s41557-020-00612-yRecent experiments reporting the isomerization of CO on a NaCl(100) surface—from C adsorbed to O adsorbed—represent a major challenge to simulate from first principles. Now, using dynamics calculations and (CO–NaCl)n cluster models that feature CO–CO interactions, it...
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Nature Chemistry, Published online: 11 January 2021; doi:10.1038/s41557-020-00609-7A wide variety of bioactive molecules contain stereogenic quaternary carbons, and developing methods for the construction of these stereocentres continues to be an active area of research. Now, it has been shown that a nickel-catalysed enantioconvergent coupling of tertiary...
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Nature Chemistry, Published online: 30 December 2020; doi:10.1038/s41557-020-00576-zMethods for producing organic molecules rich in sp3-hybridized carbon centres can be particularly useful for drug development. Now, it has been shown that the enantioselective cross-coupling of non-activated alkyl halides with alkenyl boronates enables the synthesis...
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Nature Chemistry, Published online: 30 December 2020; doi:10.1038/s41557-020-00610-0Energy scrambling in intermediate complexes—which form in many chemical reactions—presents a major challenge to state-to-state control. However, nuclear spin tends to remain unchanged throughout reactions and now, by manipulating the reactants’ nuclear spins using an...
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Nature Chemistry, Published online: 30 December 2020; doi:10.1038/s41557-020-00606-wHigh-throughput biocatalytic screening and metagenomics have been used to discover over 300 imine reductases (IREDs) and subsequently produce a sequence-diverse panel of IREDs suitable for optimizing the synthesis of chiral amines. Additional characterization identified...
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Nature Chemistry, Published online: 22 December 2020; doi:10.1038/s41557-020-00615-9Site-specific attachment of a programmable motif, such as a synthetic nucleic acid tag, on a target protein can facilitate functional studies of proteins in cells or modulation of protein activity. Now, a small genetically encoded peptide enables the templated incorporation...
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Nature Chemistry, Published online: 22 December 2020; doi:10.1038/s41557-020-00616-8Michelle Francl wonders if scientists ought to pen poetry.
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Nature Chemistry, Published online: 22 December 2020; doi:10.1038/s41557-020-00596-9Automated synthesis technologies are often highly specialized, focusing only on a narrow set of reaction classes. Now, solid-phase peptide synthesis, iterative Suzuki–Miyaura cross-coupling and diazirine chemistry have all been automated using the same universal platform...
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Nature Chemistry, Published online: 22 December 2020; doi:10.1038/s41557-020-00617-7Storytelling can be a powerful educational tool to help address equity in the chemical sciences.
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Nature Chemistry, Published online: 22 December 2020; doi:10.1038/s41557-020-00601-1Polyether ionophores are natural products that display antibacterial activity—but they also show activity against mammalian cells, which has limited their development as clinical antibiotics. Now, a semisynthesis principle of recycling substructures from highly abundant...
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