Author Correction: Directing-group-free catalytic dicarbofunctionalization of unactivated alkenes

Nature Chemistry, Published online: 13 January 2022; doi:10.1038/s41557-022-00891-7Author Correction: Directing-group-free catalytic dicarbofunctionalization of unactivated alkenes

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Scalable and selective deuteration of (hetero)arenes

Nature Chemistry, Published online: 13 January 2022; doi:10.1038/s41557-021-00846-4A method for the selective deuteration of anilines, indoles, phenols and heterocyclic compounds, including natural products and other bioactive molecules, has been developed. The nanostructured iron catalyst that underpins this process is prepared by combining cellulose...

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Quinine fever

Nature Chemistry, Published online: 07 January 2022; doi:10.1038/s41557-021-00872-2John Woodland and Kelly Chibale retrace the tumultuous history of quinine from a medicine — used as a tool for colonialism — to a puzzling chemical target, a fluorescence standard and a key ingredient in popular drinks.

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Observation of robust energy transfer in the photosynthetic protein allophycocyanin using single-molecule pump–probe spectroscopy

Nature Chemistry, Published online: 06 January 2022; doi:10.1038/s41557-021-00841-9In photosynthesis, photoenergy transfers through chromophore-containing proteins, which exhibit thermal fluctuations that change the positions of the chromophores. Now the ultrafast dynamics in allophycocyanin—a cyanobacterial light-harvesting protein—have been measured...

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Release of linker histone from the nucleosome driven by polyelectrolyte competition with a disordered protein

Nature Chemistry, Published online: 06 January 2022; doi:10.1038/s41557-021-00839-3Histone H1 binds to nucleosomes with ultrahigh affinity, implying residence times incompatible with efficient biological regulation. Now it has been shown that the disordered regions of H1 retain their large-amplitude dynamics on the nucleosome, which enables a charged...

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A hydroxide lock for metallo-β-lactamases

Nature Chemistry, Published online: 05 January 2022; doi:10.1038/s41557-021-00871-3It is extremely difficult to design a broad-spectrum inhibitor for metallo-β-lactamases (MBLs) due to the diversity in the active site. Now, indole-2-carboxylates have been developed as broad-spectrum inhibitors for MBLs. These inhibitors take advantage of key elements...

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Decarboxylative cross-nucleophile coupling via ligand-to-metal charge transfer photoexcitation of Cu(<span class="small-caps u-small-caps">ii</span>) carboxylates

Nature Chemistry, Published online: 05 January 2022; doi:10.1038/s41557-021-00834-8Direct coupling methods, which do not require substrate prefunctionalization, are highly desirable for the construction of complex molecular scaffolds. Now, a photochemical method has been developed for the direct decarboxylative coupling of carboxylic acids with diverse...

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Aluminium analogue of oxirane

Nature Chemistry, Published online: 05 January 2022; doi:10.1038/s41557-021-00873-1Aluminium analogue of oxirane

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Ammonia formation revisited

Nature Chemistry, Published online: 23 December 2021; doi:10.1038/s41557-021-00857-1Dinitrogen conversion to ammonia is of great biological and industrial relevance, but modelling this process on a molecular level is challenging. Now, a biomimetic model offers new insights into the functionalization of a nitrido ligand to form NH3 using either H2 or...

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Hydration determines anion accumulation

Nature Chemistry, Published online: 23 December 2021; doi:10.1038/s41557-021-00864-2Why do bulky anions solubilize macromolecules in water but precipitate out the corresponding monomers? The answer lies in the differences in local water structure. Polymers have now been shown to disrupt water structure more than their monomers, leading to an accumulation...

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