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Palladium-catalysed construction of butafulvenes

Nature Chemistry, Published online: 18 August 2022; doi:10.1038/s41557-022-01017-9Butafulvene is a constitutional isomer of benzene, comprising a cyclobutene skeleton bearing two exocyclic conjugated methylene units. Strategies for the synthesis of butafulvene compounds are currently limited due to its intrinsic high strain energy and anti-aromaticity....

Biosynthesis and characterization of fuscimiditide, an aspartimidylated graspetide

Nature Chemistry, Published online: 18 August 2022; doi:10.1038/s41557-022-01022-yThe biosynthesis of fuscimiditide, a ribosomally synthesized post-translationally modified peptide, has now been reported. Heterologous expression and analysis of fuscimiditide showed it contained two side-chain–side-chain ester linkages and an aspartimide in its backbone....

Different timescales during ultrafast stilbene isomerization in the gas and liquid phases revealed using time-resolved photoelectron spectroscopy

Nature Chemistry, Published online: 11 August 2022; doi:10.1038/s41557-022-01012-0The influence that liquid environments have on the ultrafast excited-state dynamics of molecules is poorly understood. Using time-resolved photoelectron spectroscopy, the dynamics of the photoisomerization of stilbene in the gas and liquid phases have now been shown to...

Filling of a water-free void explains the allosteric regulation of the β<sub>1</sub>-adrenergic receptor by cholesterol

Nature Chemistry, Published online: 11 August 2022; doi:10.1038/s41557-022-01009-9The β1-adrenergic receptor (β1AR) contains empty cavities in its preactive conformation, which disappear in the active one. Now, using X-ray crystallography of xenon-derivatized β1AR crystals, a cavity has been shown to be in contact with the cholesterol-binding pocket....

Standardized excitable elements for scalable engineering of far-from-equilibrium chemical networks

Nature Chemistry, Published online: 04 August 2022; doi:10.1038/s41557-022-01001-3Synthetic chemical networks with far-from-equilibrium dynamics akin to genetic regulatory networks in living cells could precisely regulate the kinetics of chemical synthesis or self-assembly. Now standardized excitable chemical regulatory elements, termed genelets, that...

The ribosome stabilizes partially folded intermediates of a nascent multi-domain protein

Nature Chemistry, Published online: 04 August 2022; doi:10.1038/s41557-022-01004-0Most proteins must fold co-translationally on the ribosome to adopt biologically active conformations, yet structural, mechanistic descriptions are lacking. Using 19F NMR spectroscopy to study a nascent multi-domain protein has now enabled the identification of two co-translational...

Synthesis of a low-valent Al<sub>4</sub><sup>+</sup> cluster cation salt

Nature Chemistry, Published online: 04 August 2022; doi:10.1038/s41557-022-01000-4Although neutral and anionic low-valent aluminium complexes are widespread, their cationic counterparts have remained rare. Now, a salt of [Al(AlCp*)3]+ featuring a formal low-valent Al+ cation has been isolated that dimerizes in concentrated solutions and the solid state,...

Photochemical single-step synthesis of β-amino acid derivatives from alkenes and (hetero)arenes

Nature Chemistry, Published online: 01 August 2022; doi:10.1038/s41557-022-01008-wThe majority of methods to prepare β-amino acid derivatives require metal-mediated multistep manipulations of pre-functionalized substrates. Now, a metal-free, energy-transfer enabled, highly regioselective aminocarboxylation reaction has been developed, for the single-step...

Ambient-light-induced intermolecular Coulombic decay in unbound pyridine monomers

Nature Chemistry, Published online: 31 July 2022; doi:10.1038/s41557-022-01002-2Intermolecular Coulombic decay (ICD) is a process whereby a photoexcited molecule relaxes while ionizing a neighbouring molecule. ICD is efficient when intermolecular interactions are active and consequently it is usually observed in weakly bound systems. Now, an efficient...

Electric field maps in enzymes

Nature Chemistry, Published online: 29 July 2022; doi:10.1038/s41557-022-01010-2How electric fields generated by enzyme active sites push and pull on substrates is important to their chemistry, but measuring them is difficult. Now, the electric field within an active site has been measured along two directions using a vibrational probe, revealing that...

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