Nature Chemistry, Published online: 30 November 2023; doi:10.1038/s41557-023-01364-1The synthesis of two-dimensional (2D) organic lateral heterostructures with desirable properties from organic single crystals remains challenging. Now, 2D organic lateral heterostructures have been produced by using a liquid-phase growth approach and vapour-phase growth...

Nature Chemistry, Published online: 30 November 2023; doi:10.1038/s41557-023-01373-0Daniel Rabinovich outlines the story of insulin, the essential drug for the treatment of diabetes during the past century.

Nature Chemistry, Published online: 30 November 2023; doi:10.1038/s41557-023-01377-wFluoroalkyl fragments are ubiquitous motifs in pharmaceuticals and agrochemicals, but their introduction to a given molecule typically involves expensive or difficult-to-handle reagents. Now, the photocatalysed hydrofluoroalkylation of alkenes has been achieved using...

Nature Chemistry, Published online: 30 November 2023; doi:10.1038/s41557-023-01394-9The year dot

Nature Chemistry, Published online: 30 November 2023; doi:10.1038/s41557-023-01370-3Stereoselective decarboxylative protonation can produce diverse chiral molecules from widely available carboxylic acids. However, general and practical strategies are lacking. Now, a chiral spirocyclic phosphoric acid-catalysed decarboxylation of aminomalonic acids has...

Nature Chemistry, Published online: 30 November 2023; doi:10.1038/s41557-023-01369-wRecent improvements in de novo protein design are likely to support a broad range of applications, but larger complexes will be easier to create if a building block approach is adopted. Now protein filaments with tunable geometry can be made using assemblies that have...