Nature Chemical Biology - Issue - nature.com science feeds
Nature Chemical Biology, Published online: 27 March 2024; doi:10.1038/s41589-024-01597-2TERT was dephosphorylated by the protein phosphatase activity of the gluconeogenic enzyme FBP1, leading to inhibition of TERT nuclear translocation and telomere function. Lipid nanoparticle-delivered FBP1 mRNA blunts tumor growth in mice.
Nature Chemical Biology, Published online: 26 March 2024; doi:10.1038/s41589-024-01594-5Chemogenetic profiling can reveal genetic determinants that coordinate phenotypic responses to therapeutics, along with predicting potential pathways of resistance. A new analytical method for evaluating chemogenetic profiles reveals contributions from death-regulatory...
Nature Chemical Biology, Published online: 25 March 2024; doi:10.1038/s41589-024-01586-5Exportin-1 (XPO1) was identified as the target of small molecules suppressing T cell activation. Selective disruption of the chromatin scaffolding function of XPO1 without blocking nuclear export implicates XPO1 as a target in autoimmunity.
Nature Chemical Biology, Published online: 25 March 2024; doi:10.1038/s41589-024-01588-3A proteomics and computational approach was developed to map the proximal proteome of the activated μ-opioid receptor and to extract subcellular location, trafficking and functional partners of G-protein-coupled receptor activity.
Nature Chemical Biology, Published online: 25 March 2024; doi:10.1038/s41589-024-01601-9Stress it up
Nature Chemical Biology, Published online: 25 March 2024; doi:10.1038/s41589-024-01602-8Reeling in microorganisms
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