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Fructose-1,6-bisphosphatase 1 dephosphorylates and inhibits TERT for tumor suppression

Nature Chemical Biology, Published online: 27 March 2024; doi:10.1038/s41589-024-01597-2TERT was dephosphorylated by the protein phosphatase activity of the gluconeogenic enzyme FBP1, leading to inhibition of TERT nuclear translocation and telomere function. Lipid nanoparticle-delivered FBP1 mRNA blunts tumor growth in mice.

Wed Mar 27, 2024 15:18
The death gaze of MEDUSA

Nature Chemical Biology, Published online: 26 March 2024; doi:10.1038/s41589-024-01594-5Chemogenetic profiling can reveal genetic determinants that coordinate phenotypic responses to therapeutics, along with predicting potential pathways of resistance. A new analytical method for evaluating chemogenetic profiles reveals contributions from death-regulatory...

Tue Mar 26, 2024 16:50
Targeting the chromatin binding of exportin-1 disrupts NFAT and T cell activation

Nature Chemical Biology, Published online: 25 March 2024; doi:10.1038/s41589-024-01586-5Exportin-1 (XPO1) was identified as the target of small molecules suppressing T cell activation. Selective disruption of the chromatin scaffolding function of XPO1 without blocking nuclear export implicates XPO1 as a target in autoimmunity.

Mon Mar 25, 2024 15:23
Profiling the proximal proteome of the activated μ-opioid receptor

Nature Chemical Biology, Published online: 25 March 2024; doi:10.1038/s41589-024-01588-3A proteomics and computational approach was developed to map the proximal proteome of the activated μ-opioid receptor and to extract subcellular location, trafficking and functional partners of G-protein-coupled receptor activity.

Mon Mar 25, 2024 15:23
Stress it up

Nature Chemical Biology, Published online: 25 March 2024; doi:10.1038/s41589-024-01601-9Stress it up

Mon Mar 25, 2024 13:52
Reeling in microorganisms

Nature Chemical Biology, Published online: 25 March 2024; doi:10.1038/s41589-024-01602-8Reeling in microorganisms

Mon Mar 25, 2024 13:52

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